Investigating the potential causal association between consumption of green tea and risk of lung cancer: a study utilizing Mendelian randomization
BackgroundLung cancer is the most common global cancer in terms of incidence and mortality. Its main driver is tobacco smoking. The identification of modifiable risk factors isa public health priority. Green tea consumption has been examined in epidemiological studies, with inconsistent findings. Th...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1265878/full |
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| author | Jieming Lu Jieming Lu Ye Lin Ye Lin Junfei Jiang Junfei Jiang Lei Gao Lei Gao Lei Gao Lei Gao Zhimin Shen Zhimin Shen Zhimin Shen Zhimin Shen Changping Yang Pinghua Lin Mingqiang Kang Mingqiang Kang Mingqiang Kang Mingqiang Kang |
| author_facet | Jieming Lu Jieming Lu Ye Lin Ye Lin Junfei Jiang Junfei Jiang Lei Gao Lei Gao Lei Gao Lei Gao Zhimin Shen Zhimin Shen Zhimin Shen Zhimin Shen Changping Yang Pinghua Lin Mingqiang Kang Mingqiang Kang Mingqiang Kang Mingqiang Kang |
| author_sort | Jieming Lu |
| collection | DOAJ |
| description | BackgroundLung cancer is the most common global cancer in terms of incidence and mortality. Its main driver is tobacco smoking. The identification of modifiable risk factors isa public health priority. Green tea consumption has been examined in epidemiological studies, with inconsistent findings. Thus, we aimed to apply Mendelian randomization to clarify any causal link between green tea consumption and the risk of lung cancer.MethodsWe utilized a two-sample Mendelian randomization (MR) approach. Genetic variants served as instrumental variables. The goal was to explore a causal link between green tea consumption and different lung cancer types. Green tea consumption data was sourced from the UK Biobank dataset, and the genetic association data for various types of lung cancer were sourced from multiple databases. Our analysis included primary inverse-variance weighted (IVW) analyses and various sensitivity test.ResultsNo significant associations were found between green tea intake and any lung cancer subtypes, including non-small cell lung cancer (adenocarcinoma and squamous cell carcinoma) and small cell lung cancer. These findings were consistent when applying multiple Mendelian randomization methods.ConclusionGreen tea does not appear to offer protective benefits against lung cancer at a population level. However, lung cancer's complex etiology and green tea's potential health benefitssuggest more research is needed. Further studies should include diverse populations, improved exposure measurements and randomized controlled trials, are warranted. |
| first_indexed | 2024-03-07T23:52:22Z |
| format | Article |
| id | doaj.art-bfd51f32d857493999abb90f91b4cb77 |
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| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-07T23:52:22Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-bfd51f32d857493999abb90f91b4cb772024-02-19T04:30:59ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-02-011110.3389/fnut.2024.12658781265878Investigating the potential causal association between consumption of green tea and risk of lung cancer: a study utilizing Mendelian randomizationJieming Lu0Jieming Lu1Ye Lin2Ye Lin3Junfei Jiang4Junfei Jiang5Lei Gao6Lei Gao7Lei Gao8Lei Gao9Zhimin Shen10Zhimin Shen11Zhimin Shen12Zhimin Shen13Changping Yang14Pinghua Lin15Mingqiang Kang16Mingqiang Kang17Mingqiang Kang18Mingqiang Kang19Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaKey Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, Fuzhou, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaKey Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, Fuzhou, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaKey Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, Fuzhou, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaKey Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, Fuzhou, ChinaKey Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, ChinaFujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaKey Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, Fuzhou, ChinaKey Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, ChinaFujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, ChinaFuqing City Hospital Affiliated to Fujian Medical University, Fuzhou, ChinaFuqing City Hospital Affiliated to Fujian Medical University, Fuzhou, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaKey Laboratory of Cardio-Thoracic Surgery, Fujian Medical University, Fuzhou, ChinaKey Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, ChinaFujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, ChinaBackgroundLung cancer is the most common global cancer in terms of incidence and mortality. Its main driver is tobacco smoking. The identification of modifiable risk factors isa public health priority. Green tea consumption has been examined in epidemiological studies, with inconsistent findings. Thus, we aimed to apply Mendelian randomization to clarify any causal link between green tea consumption and the risk of lung cancer.MethodsWe utilized a two-sample Mendelian randomization (MR) approach. Genetic variants served as instrumental variables. The goal was to explore a causal link between green tea consumption and different lung cancer types. Green tea consumption data was sourced from the UK Biobank dataset, and the genetic association data for various types of lung cancer were sourced from multiple databases. Our analysis included primary inverse-variance weighted (IVW) analyses and various sensitivity test.ResultsNo significant associations were found between green tea intake and any lung cancer subtypes, including non-small cell lung cancer (adenocarcinoma and squamous cell carcinoma) and small cell lung cancer. These findings were consistent when applying multiple Mendelian randomization methods.ConclusionGreen tea does not appear to offer protective benefits against lung cancer at a population level. However, lung cancer's complex etiology and green tea's potential health benefitssuggest more research is needed. Further studies should include diverse populations, improved exposure measurements and randomized controlled trials, are warranted.https://www.frontiersin.org/articles/10.3389/fnut.2024.1265878/fulllung cancergreen teaMendelian randomizationpolyphenolsepigallocatechin-3-gallate (EGCG)Genome-Wide Association Study (GWAS) |
| spellingShingle | Jieming Lu Jieming Lu Ye Lin Ye Lin Junfei Jiang Junfei Jiang Lei Gao Lei Gao Lei Gao Lei Gao Zhimin Shen Zhimin Shen Zhimin Shen Zhimin Shen Changping Yang Pinghua Lin Mingqiang Kang Mingqiang Kang Mingqiang Kang Mingqiang Kang Investigating the potential causal association between consumption of green tea and risk of lung cancer: a study utilizing Mendelian randomization Frontiers in Nutrition lung cancer green tea Mendelian randomization polyphenols epigallocatechin-3-gallate (EGCG) Genome-Wide Association Study (GWAS) |
| title | Investigating the potential causal association between consumption of green tea and risk of lung cancer: a study utilizing Mendelian randomization |
| title_full | Investigating the potential causal association between consumption of green tea and risk of lung cancer: a study utilizing Mendelian randomization |
| title_fullStr | Investigating the potential causal association between consumption of green tea and risk of lung cancer: a study utilizing Mendelian randomization |
| title_full_unstemmed | Investigating the potential causal association between consumption of green tea and risk of lung cancer: a study utilizing Mendelian randomization |
| title_short | Investigating the potential causal association between consumption of green tea and risk of lung cancer: a study utilizing Mendelian randomization |
| title_sort | investigating the potential causal association between consumption of green tea and risk of lung cancer a study utilizing mendelian randomization |
| topic | lung cancer green tea Mendelian randomization polyphenols epigallocatechin-3-gallate (EGCG) Genome-Wide Association Study (GWAS) |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1265878/full |
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