Carbamazepine Induced Thrombocytopenia
Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia, neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On exploring through the literature, older AEDs are more associated with haematologic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10659/26271_CE(RA1)_F(T)_PF1(PG_GG_VJ_PY)_PFA(VJ_SS).pdf |
| Summary: | Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia,
neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On exploring through the literature,
older AEDs are more associated with haematological alterations than newer AEDs, and careful monitoring is warranted especially
with phenytoin, carbamazepine and valproate. The exact cause of these alterations is not established, though immune mechanisms
and pharmacology of individual drugs are the proposed mechanisms, a further research along this path is underway. Of worth
mentioning here, this predilection of older AEDs towards haematological disorders is pronounced in children compared to adults.
We present here a case of congenital heart disease with history of brain abscess and seizures, on carbamazepine who presented to
our hospital with toothache. Routine screening prior to tooth extraction revealed thrombocytopenia. Further evaluation revealed the
association of carbamazepine and thrombocytopenia, which mandated discontinuation of drug and switching patient to alternative
AED. |
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| ISSN: | 2249-782X 0973-709X |