Carbamazepine Induced Thrombocytopenia
Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia, neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On exploring through the literature, older AEDs are more associated with haematologic...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/10659/26271_CE(RA1)_F(T)_PF1(PG_GG_VJ_PY)_PFA(VJ_SS).pdf |
| _version_ | 1818642856325152768 |
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| author | Ruhi Kumar Sridhar Chivukula Goutham Reddy Katukur U K Chandrasekhar K N Shivashankar |
| author_facet | Ruhi Kumar Sridhar Chivukula Goutham Reddy Katukur U K Chandrasekhar K N Shivashankar |
| author_sort | Ruhi Kumar |
| collection | DOAJ |
| description | Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia,
neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On exploring through the literature,
older AEDs are more associated with haematological alterations than newer AEDs, and careful monitoring is warranted especially
with phenytoin, carbamazepine and valproate. The exact cause of these alterations is not established, though immune mechanisms
and pharmacology of individual drugs are the proposed mechanisms, a further research along this path is underway. Of worth
mentioning here, this predilection of older AEDs towards haematological disorders is pronounced in children compared to adults.
We present here a case of congenital heart disease with history of brain abscess and seizures, on carbamazepine who presented to
our hospital with toothache. Routine screening prior to tooth extraction revealed thrombocytopenia. Further evaluation revealed the
association of carbamazepine and thrombocytopenia, which mandated discontinuation of drug and switching patient to alternative
AED. |
| first_indexed | 2024-12-16T23:49:42Z |
| format | Article |
| id | doaj.art-bfd6a61b084344ee94d5e6bd138c4e90 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-16T23:49:42Z |
| publishDate | 2017-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-bfd6a61b084344ee94d5e6bd138c4e902022-12-21T22:11:23ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-09-01119OD12OD1310.7860/JCDR/2017/26271.10659Carbamazepine Induced ThrombocytopeniaRuhi Kumar0Sridhar Chivukula1Goutham Reddy Katukur2U K Chandrasekhar3K N Shivashankar4Intern, Department of General Medicine, Kasturba Medical College, Manipal, Karnataka, India.Junior Resident, Department of General Medicine, Kasturba Medical College, Manipal, Karnataka, India.Junior Resident, Department of General Medicine, Kasturba Medical College, Manipal, Karnataka, India.Associate Professor, Department of General Medicine, Kasturba Medical College, Manipal, Karnataka, India.Professor, Department of General Medicine, Kasturba Medical College, Manipal, Karnataka, India.Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia, neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On exploring through the literature, older AEDs are more associated with haematological alterations than newer AEDs, and careful monitoring is warranted especially with phenytoin, carbamazepine and valproate. The exact cause of these alterations is not established, though immune mechanisms and pharmacology of individual drugs are the proposed mechanisms, a further research along this path is underway. Of worth mentioning here, this predilection of older AEDs towards haematological disorders is pronounced in children compared to adults. We present here a case of congenital heart disease with history of brain abscess and seizures, on carbamazepine who presented to our hospital with toothache. Routine screening prior to tooth extraction revealed thrombocytopenia. Further evaluation revealed the association of carbamazepine and thrombocytopenia, which mandated discontinuation of drug and switching patient to alternative AED.https://jcdr.net/articles/PDF/10659/26271_CE(RA1)_F(T)_PF1(PG_GG_VJ_PY)_PFA(VJ_SS).pdfantiepileptic drugscyanotic congenital heart diseasehaematological alterations |
| spellingShingle | Ruhi Kumar Sridhar Chivukula Goutham Reddy Katukur U K Chandrasekhar K N Shivashankar Carbamazepine Induced Thrombocytopenia Journal of Clinical and Diagnostic Research antiepileptic drugs cyanotic congenital heart disease haematological alterations |
| title | Carbamazepine Induced Thrombocytopenia |
| title_full | Carbamazepine Induced Thrombocytopenia |
| title_fullStr | Carbamazepine Induced Thrombocytopenia |
| title_full_unstemmed | Carbamazepine Induced Thrombocytopenia |
| title_short | Carbamazepine Induced Thrombocytopenia |
| title_sort | carbamazepine induced thrombocytopenia |
| topic | antiepileptic drugs cyanotic congenital heart disease haematological alterations |
| url | https://jcdr.net/articles/PDF/10659/26271_CE(RA1)_F(T)_PF1(PG_GG_VJ_PY)_PFA(VJ_SS).pdf |
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