Effect of bloodstream infection on survival in COVID-19 patients admitted to an intensive care unit in Colombia: a matched cohort analysis
Summary: Aim: To determine the impact of bloodstream infection (BSI) and other risk factors for mortality in patients with COVID-19 admitted to the intensive care unit (ICU). Methods: A retrospective cohort was carried out at the Hospital Universitario Nacional (HUN) between March 29 and December 1...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Infection Prevention in Practice |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590088923000161 |
| _version_ | 1797818304171081728 |
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| author | Jorge Alberto Cortes Martha Carolina Valderrama-Rios Laura Cristina Nocua-Báez Lina María Quitián Fabio Alexander Lozada Giancarlo Buitrago |
| author_facet | Jorge Alberto Cortes Martha Carolina Valderrama-Rios Laura Cristina Nocua-Báez Lina María Quitián Fabio Alexander Lozada Giancarlo Buitrago |
| author_sort | Jorge Alberto Cortes |
| collection | DOAJ |
| description | Summary: Aim: To determine the impact of bloodstream infection (BSI) and other risk factors for mortality in patients with COVID-19 admitted to the intensive care unit (ICU). Methods: A retrospective cohort was carried out at the Hospital Universitario Nacional (HUN) between March 29 and December 19, 2020. Patients with COVID-19 admitted to the Intensive Care Unit (ICU) were paired 1:4 in two groups, one with BSI and the other without, according to hospital stay and the month of admission. The primary outcome was mortality at 28 days. A Cox proportional hazards model was used to estimate differences in mortality risk. Results: 456 patients were identified and 320 were included in the final cohort, 18% (n = 59) in the BSI group and 82% (n = 261) in the control group. 125 (39%) patients died, 30 (51%) in the BSI group and 95 (36%) in the control group (P = 0.040). BSI was associated with an increased risk of in-hospital mortality at 28 days, [HR] 1.77 (95% CI: 1.03–3.02; P = 0.037). Invasive mechanical ventilation (IMV) and age were associated with increased mortality risk. Some months of the year of the hospital stay were associated with a reduced risk of mortality. There was no difference in mortality between inappropriate and appropriate empirical antimicrobial use. Conclusion: BSI in patients with COVID-19 in ICU increases in-hospital mortality to 28 days. Other risk factors for mortality were IMV and age. |
| first_indexed | 2024-03-13T09:07:10Z |
| format | Article |
| id | doaj.art-bfd6ef5feb184735b2822b6047358a71 |
| institution | Directory Open Access Journal |
| issn | 2590-0889 |
| language | English |
| last_indexed | 2024-03-13T09:07:10Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Infection Prevention in Practice |
| spelling | doaj.art-bfd6ef5feb184735b2822b6047358a712023-05-28T04:09:10ZengElsevierInfection Prevention in Practice2590-08892023-06-0152100283Effect of bloodstream infection on survival in COVID-19 patients admitted to an intensive care unit in Colombia: a matched cohort analysisJorge Alberto Cortes0Martha Carolina Valderrama-Rios1Laura Cristina Nocua-Báez2Lina María Quitián3Fabio Alexander Lozada4Giancarlo Buitrago5Department of Internal Medicine, Universidad Nacional de Colombia, Sede Bogotá, Facultad de Medicina, Bogotá, Colombia; Infectious Diseases Service, Hospital Universitario Nacional, Bogotá, ColombiaDepartment of Internal Medicine, Universidad Nacional de Colombia, Sede Bogotá, Facultad de Medicina, Bogotá, ColombiaDepartment of Internal Medicine, Universidad Nacional de Colombia, Sede Bogotá, Facultad de Medicina, Bogotá, Colombia; Infectious Diseases Service, Hospital Universitario Nacional, Bogotá, Colombia; Corresponding author. Oficina de Investigación Clínica, Hospital Universitario Nacional, Calle 44 no. 59-75, Primer piso, Bogotá, Colombia.Department of Internal Medicine, Universidad Nacional de Colombia, Sede Bogotá, Facultad de Medicina, Bogotá, ColombiaDepartment of Internal Medicine, Universidad Nacional de Colombia, Sede Bogotá, Facultad de Medicina, Bogotá, ColombiaResearch Institute, Universidad Nacional de Colombia, Sede Bogotá, Facultad de Medicina, Bogotá, ColombiaSummary: Aim: To determine the impact of bloodstream infection (BSI) and other risk factors for mortality in patients with COVID-19 admitted to the intensive care unit (ICU). Methods: A retrospective cohort was carried out at the Hospital Universitario Nacional (HUN) between March 29 and December 19, 2020. Patients with COVID-19 admitted to the Intensive Care Unit (ICU) were paired 1:4 in two groups, one with BSI and the other without, according to hospital stay and the month of admission. The primary outcome was mortality at 28 days. A Cox proportional hazards model was used to estimate differences in mortality risk. Results: 456 patients were identified and 320 were included in the final cohort, 18% (n = 59) in the BSI group and 82% (n = 261) in the control group. 125 (39%) patients died, 30 (51%) in the BSI group and 95 (36%) in the control group (P = 0.040). BSI was associated with an increased risk of in-hospital mortality at 28 days, [HR] 1.77 (95% CI: 1.03–3.02; P = 0.037). Invasive mechanical ventilation (IMV) and age were associated with increased mortality risk. Some months of the year of the hospital stay were associated with a reduced risk of mortality. There was no difference in mortality between inappropriate and appropriate empirical antimicrobial use. Conclusion: BSI in patients with COVID-19 in ICU increases in-hospital mortality to 28 days. Other risk factors for mortality were IMV and age.http://www.sciencedirect.com/science/article/pii/S2590088923000161COVID-19SARS-Cov-2Critical careBacteraemiaMechanical ventilationMortality |
| spellingShingle | Jorge Alberto Cortes Martha Carolina Valderrama-Rios Laura Cristina Nocua-Báez Lina María Quitián Fabio Alexander Lozada Giancarlo Buitrago Effect of bloodstream infection on survival in COVID-19 patients admitted to an intensive care unit in Colombia: a matched cohort analysis Infection Prevention in Practice COVID-19 SARS-Cov-2 Critical care Bacteraemia Mechanical ventilation Mortality |
| title | Effect of bloodstream infection on survival in COVID-19 patients admitted to an intensive care unit in Colombia: a matched cohort analysis |
| title_full | Effect of bloodstream infection on survival in COVID-19 patients admitted to an intensive care unit in Colombia: a matched cohort analysis |
| title_fullStr | Effect of bloodstream infection on survival in COVID-19 patients admitted to an intensive care unit in Colombia: a matched cohort analysis |
| title_full_unstemmed | Effect of bloodstream infection on survival in COVID-19 patients admitted to an intensive care unit in Colombia: a matched cohort analysis |
| title_short | Effect of bloodstream infection on survival in COVID-19 patients admitted to an intensive care unit in Colombia: a matched cohort analysis |
| title_sort | effect of bloodstream infection on survival in covid 19 patients admitted to an intensive care unit in colombia a matched cohort analysis |
| topic | COVID-19 SARS-Cov-2 Critical care Bacteraemia Mechanical ventilation Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2590088923000161 |
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