Overall adjustment acupuncture improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats
BackgroundAcupuncture is a widely practiced, convenient, and safe treatment modality within complementary and integrative medicine. Increasing studies have revealed the efficacy of acupuncture for the treatment of osteoporosis in both human and non-human subjects. The aim of the present study was to...
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| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1074516/full |
| _version_ | 1828098306779119616 |
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| author | Xiang Li Kenan Wu Qinzuo Dong Hongxi Chen Chunyan Li Zeqin Ren Fan Liu Xianwu Yue Chunlin Xia Yuanfeng Wang Yingjing Luo Li Li Rong Zhao Zuhong Wang Dongdong Qin |
| author_facet | Xiang Li Kenan Wu Qinzuo Dong Hongxi Chen Chunyan Li Zeqin Ren Fan Liu Xianwu Yue Chunlin Xia Yuanfeng Wang Yingjing Luo Li Li Rong Zhao Zuhong Wang Dongdong Qin |
| author_sort | Xiang Li |
| collection | DOAJ |
| description | BackgroundAcupuncture is a widely practiced, convenient, and safe treatment modality within complementary and integrative medicine. Increasing studies have revealed the efficacy of acupuncture for the treatment of osteoporosis in both human and non-human subjects. The aim of the present study was to assess the improvement of osteoporosis after overall adjustment acupuncture (OA) as well as its endocrine-modulating effect in an ovariectomized rat model.MethodsIn total, 32 female Sprague–Dawley (SD) rats were randomly divided into the sham, model, ovariectomy+estrogen (OVX+E), and OVX+OA (OVX+A) groups with eight rats in each group. The postmenopausal osteoporosis (PMOP) rat model was induced by bilateral ovariectomy. At 12 weeks after surgery, rats in the OVX+E group received estradiol (0.2 mg/kg/i.g./qod) for 12 weeks, and rats in the OVX+A group were treated with acupuncture at Zusanli (ST36), Shenshu (BL23), and Dazhu (BL11) points (qod) for 12 weeks. At the end of the treatment, all rats were sacrificed, and the body weight, uterus index, bone mineral density (BMD), bone mineral content (BMC), bone trabeculae structural parameters, femoral biomechanical properties, femoral histomorphology, and several hormone levels were examined.ResultsIn OVX rats, OA abrogated the body weight gain and improved osteoporosis in terms of BMD, BMC, bone trabeculae structural parameters, bone strength, and bone tissue histomorphology. Moreover, OA modulated the serum levels of estradiol, corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosterone (CORT).ConclusionsOA improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats. |
| first_indexed | 2024-04-11T08:00:41Z |
| format | Article |
| id | doaj.art-bfd7e56c5f9242eb9f3d90f6ca0be9a4 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T08:00:41Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-bfd7e56c5f9242eb9f3d90f6ca0be9a42022-12-22T04:35:44ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10745161074516Overall adjustment acupuncture improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized ratsXiang Li0Kenan Wu1Qinzuo Dong2Hongxi Chen3Chunyan Li4Zeqin Ren5Fan Liu6Xianwu Yue7Chunlin Xia8Yuanfeng Wang9Yingjing Luo10Li Li11Rong Zhao12Zuhong Wang13Dongdong Qin14The First Clinical Medical School, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaThe Second Clinical Medical School, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaThe Second Clinical Medical School, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaThe Second Clinical Medical School, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaDepartment of Life Technology Teaching and Research, School of Life Science, Southwest Forestry University, Kunming, Yunnan, ChinaDepartment of Rehabilitation, The First Affiliated Hospital of Dali University, Dali University, Dali, Yunnan, ChinaThe Second Clinical Medical School, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaThe Second Clinical Medical School, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaThe Second Clinical Medical School, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaDepartment of Acupuncture, Qujing Hospital of Traditional Chinese Medicine, Qujing, Yunnan, ChinaThe Affiliated Hospital, Yunnan Institute of Traditional Chinese Medicine, Kunming, Yunnan, ChinaDepartment of Acupuncture and Rehabilitation, Jingzhou Hospital of Traditional Chinese Medicine, Jingzhou, Hubei, ChinaThe First Clinical Medical School, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaDepartment of Acupuncture, Kunming Hospital of Traditional Chinese Medicine, Kunming, Yunnan, ChinaSchool of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaBackgroundAcupuncture is a widely practiced, convenient, and safe treatment modality within complementary and integrative medicine. Increasing studies have revealed the efficacy of acupuncture for the treatment of osteoporosis in both human and non-human subjects. The aim of the present study was to assess the improvement of osteoporosis after overall adjustment acupuncture (OA) as well as its endocrine-modulating effect in an ovariectomized rat model.MethodsIn total, 32 female Sprague–Dawley (SD) rats were randomly divided into the sham, model, ovariectomy+estrogen (OVX+E), and OVX+OA (OVX+A) groups with eight rats in each group. The postmenopausal osteoporosis (PMOP) rat model was induced by bilateral ovariectomy. At 12 weeks after surgery, rats in the OVX+E group received estradiol (0.2 mg/kg/i.g./qod) for 12 weeks, and rats in the OVX+A group were treated with acupuncture at Zusanli (ST36), Shenshu (BL23), and Dazhu (BL11) points (qod) for 12 weeks. At the end of the treatment, all rats were sacrificed, and the body weight, uterus index, bone mineral density (BMD), bone mineral content (BMC), bone trabeculae structural parameters, femoral biomechanical properties, femoral histomorphology, and several hormone levels were examined.ResultsIn OVX rats, OA abrogated the body weight gain and improved osteoporosis in terms of BMD, BMC, bone trabeculae structural parameters, bone strength, and bone tissue histomorphology. Moreover, OA modulated the serum levels of estradiol, corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosterone (CORT).ConclusionsOA improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats.https://www.frontiersin.org/articles/10.3389/fendo.2022.1074516/fulloverall adjustment acupuncturepostmenopausal osteoporosisestradiolhypothalamus-pituitary-adrenal axisovariectomy |
| spellingShingle | Xiang Li Kenan Wu Qinzuo Dong Hongxi Chen Chunyan Li Zeqin Ren Fan Liu Xianwu Yue Chunlin Xia Yuanfeng Wang Yingjing Luo Li Li Rong Zhao Zuhong Wang Dongdong Qin Overall adjustment acupuncture improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats Frontiers in Endocrinology overall adjustment acupuncture postmenopausal osteoporosis estradiol hypothalamus-pituitary-adrenal axis ovariectomy |
| title | Overall adjustment acupuncture improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats |
| title_full | Overall adjustment acupuncture improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats |
| title_fullStr | Overall adjustment acupuncture improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats |
| title_full_unstemmed | Overall adjustment acupuncture improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats |
| title_short | Overall adjustment acupuncture improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats |
| title_sort | overall adjustment acupuncture improves osteoporosis and exerts an endocrine modulating effect in ovariectomized rats |
| topic | overall adjustment acupuncture postmenopausal osteoporosis estradiol hypothalamus-pituitary-adrenal axis ovariectomy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1074516/full |
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