Adiponectin: A Predictor for Breast Cancer Survival?
Objective:Breast cancers in women with low serum adiponectin levels have been reported to show phenotypes that are more aggressive. In 2008, we investigated the relationship between serum adiponectin levels and breast cancer in our case-controlled study involving 83 patients, in which serum adiponec...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2019-01-01
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| Series: | European Journal of Breast Health |
| Subjects: | |
| Online Access: |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/adiponectin-a-predictor-for-breast-cancer-survival/41964
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| _version_ | 1797923999383027712 |
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| author | Hikmet Erhan Güven Lütfi Doğan Mehmet Ali Gülçelik Neşe Ersöz Gülçelik |
| author_facet | Hikmet Erhan Güven Lütfi Doğan Mehmet Ali Gülçelik Neşe Ersöz Gülçelik |
| author_sort | Hikmet Erhan Güven |
| collection | DOAJ |
| description | Objective:Breast cancers in women with low serum adiponectin levels have been reported to show phenotypes that are more aggressive. In 2008, we investigated the relationship between serum adiponectin levels and breast cancer in our case-controlled study involving 83 patients, in which serum adiponectin levels were measured preoperatively. In this study, we aimed to investigate the relationship between serum adiponectin levels and breast cancer-specific survival among these 83 patients.Materials and Methods:All 83 patients with stage I-III breast cancer, whose adiponectin levels were measured preoperatively in 2008 were enrolled in this study. The patients had no history of medications influencing insulin resistance prior to collecting the blood samples. Serum adiponectin concentrations were measured after overnight fasting (≥12 hours) by drawing a venous blood sample of 30 mL from the arm. ELISA (B-Bridge Human Adiponectin ELISA kit) was used for testing.Results:The mean adiponectin level was found to be 15,300 ng/mL. When the adiponectin levels of the patients were analyzed according to the stage of the disease, adiponectin levels tended to be significantly lower as the stage increased. The stage of the disease was an important determinant for both Diseas Free Survival (DFS) (p=0.003) and Overall Survival (OS) (p=0.005). A significant relationship between adiponectin levels and OS was also observed (p=0.025), and levels of adiponectin above the mean value of 15,300 ng/mL were associated with improved DFS (p=0.001).Conclusion:Preoperative adiponectin levels may be useful to predict survival rates in breast cancer or may be used as a marker/predictor for defining patients who require more aggressive treatment. In order for adiponectin to be used as a practical clinical marker for breast cancer, large database studies are should be conducted. |
| first_indexed | 2024-04-10T14:55:49Z |
| format | Article |
| id | doaj.art-bfd835160f7f4c89973a423662c62272 |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T14:55:49Z |
| publishDate | 2019-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-bfd835160f7f4c89973a423662c622722023-02-15T16:07:23ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312019-01-01151131710.5152/ejbh.2018.434913049054Adiponectin: A Predictor for Breast Cancer Survival?Hikmet Erhan Güven0Lütfi Doğan1Mehmet Ali Gülçelik2Neşe Ersöz Gülçelik3 Department of General Surgery, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey Department of General Surgery, University of Health Sciences, Ankara Oncology Training and Research Hospital, Ankara, Turkey Department of General Surgery, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey Department of Endocrinology and Metabolism, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey Objective:Breast cancers in women with low serum adiponectin levels have been reported to show phenotypes that are more aggressive. In 2008, we investigated the relationship between serum adiponectin levels and breast cancer in our case-controlled study involving 83 patients, in which serum adiponectin levels were measured preoperatively. In this study, we aimed to investigate the relationship between serum adiponectin levels and breast cancer-specific survival among these 83 patients.Materials and Methods:All 83 patients with stage I-III breast cancer, whose adiponectin levels were measured preoperatively in 2008 were enrolled in this study. The patients had no history of medications influencing insulin resistance prior to collecting the blood samples. Serum adiponectin concentrations were measured after overnight fasting (≥12 hours) by drawing a venous blood sample of 30 mL from the arm. ELISA (B-Bridge Human Adiponectin ELISA kit) was used for testing.Results:The mean adiponectin level was found to be 15,300 ng/mL. When the adiponectin levels of the patients were analyzed according to the stage of the disease, adiponectin levels tended to be significantly lower as the stage increased. The stage of the disease was an important determinant for both Diseas Free Survival (DFS) (p=0.003) and Overall Survival (OS) (p=0.005). A significant relationship between adiponectin levels and OS was also observed (p=0.025), and levels of adiponectin above the mean value of 15,300 ng/mL were associated with improved DFS (p=0.001).Conclusion:Preoperative adiponectin levels may be useful to predict survival rates in breast cancer or may be used as a marker/predictor for defining patients who require more aggressive treatment. In order for adiponectin to be used as a practical clinical marker for breast cancer, large database studies are should be conducted. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/adiponectin-a-predictor-for-breast-cancer-survival/41964 adiponectinbreast cancersurvival |
| spellingShingle | Hikmet Erhan Güven Lütfi Doğan Mehmet Ali Gülçelik Neşe Ersöz Gülçelik Adiponectin: A Predictor for Breast Cancer Survival? European Journal of Breast Health adiponectin breast cancer survival |
| title | Adiponectin: A Predictor for Breast Cancer Survival? |
| title_full | Adiponectin: A Predictor for Breast Cancer Survival? |
| title_fullStr | Adiponectin: A Predictor for Breast Cancer Survival? |
| title_full_unstemmed | Adiponectin: A Predictor for Breast Cancer Survival? |
| title_short | Adiponectin: A Predictor for Breast Cancer Survival? |
| title_sort | adiponectin a predictor for breast cancer survival |
| topic | adiponectin breast cancer survival |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/adiponectin-a-predictor-for-breast-cancer-survival/41964
|
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