M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24407-y |
| _version_ | 1818840263853867008 |
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| author | Indira Bag Shue Chen Leah F. Rosin Yang Chen Chen-Yu Liu Guo-Yun Yu Elissa P. Lei |
| author_facet | Indira Bag Shue Chen Leah F. Rosin Yang Chen Chen-Yu Liu Guo-Yun Yu Elissa P. Lei |
| author_sort | Indira Bag |
| collection | DOAJ |
| description | Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1-dependent transcription at topologically associating domain (TAD) borders. |
| first_indexed | 2024-12-19T04:07:25Z |
| format | Article |
| id | doaj.art-bfd88957d63142eab7e9c576f5008e93 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:07:25Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bfd88957d63142eab7e9c576f5008e932022-12-21T20:36:29ZengNature PortfolioNature Communications2041-17232021-07-0112111810.1038/s41467-021-24407-yM1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activityIndira Bag0Shue Chen1Leah F. Rosin2Yang Chen3Chen-Yu Liu4Guo-Yun Yu5Elissa P. Lei6Nuclear Organization and Gene Expression SectionNuclear Organization and Gene Expression SectionNuclear Organization and Gene Expression SectionNuclear Organization and Gene Expression SectionLaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthLaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthNuclear Organization and Gene Expression SectionTranscriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1-dependent transcription at topologically associating domain (TAD) borders.https://doi.org/10.1038/s41467-021-24407-y |
| spellingShingle | Indira Bag Shue Chen Leah F. Rosin Yang Chen Chen-Yu Liu Guo-Yun Yu Elissa P. Lei M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity Nature Communications |
| title | M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity |
| title_full | M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity |
| title_fullStr | M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity |
| title_full_unstemmed | M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity |
| title_short | M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity |
| title_sort | m1bp cooperates with cp190 to activate transcription at tad borders and promote chromatin insulator activity |
| url | https://doi.org/10.1038/s41467-021-24407-y |
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