The Diagnostic Dilemma of Urothelial Tissue Fragments in Urinary Tract Cytology Specimens
Since the release of The Paris System for Reporting Urinary Cytology (TPS), the assessment of urine cytology specimens has primarily focused on the detection of high-grade urothelial carcinoma (HGUC) and carcinoma in situ (CIS). Fortunately, the malignant cells in these lesions tend to be loosely co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/4/931 |
| _version_ | 1827621075455836160 |
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| author | Derek B. Allison M. Lisa Zhang Poonam Vohra Christopher J. VandenBussche |
| author_facet | Derek B. Allison M. Lisa Zhang Poonam Vohra Christopher J. VandenBussche |
| author_sort | Derek B. Allison |
| collection | DOAJ |
| description | Since the release of The Paris System for Reporting Urinary Cytology (TPS), the assessment of urine cytology specimens has primarily focused on the detection of high-grade urothelial carcinoma (HGUC) and carcinoma in situ (CIS). Fortunately, the malignant cells in these lesions tend to be loosely cohesive, resulting in the natural exfoliation of individual malignant cells into the urine. However, HGUC/CIS lesions occasionally exfoliate larger fragments which can be difficult to assess due to cellular overlap and fragment three-dimensionality. Furthermore, reactive benign urothelial fragments and fragments from low-grade urothelial neoplasms (LGUN) may also be seen in urine specimens and contain atypical cytomorphologic features. As a result, the significance of urothelial tissue fragments (UTFs) is often unclear. Herein, we discuss the literature on UTFs before and after the implementation of TPS, as well as strategies to help overcome this diagnostic challenge. |
| first_indexed | 2024-03-09T10:57:35Z |
| format | Article |
| id | doaj.art-bfdcb83c79c646c799347c6e8ee74493 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T10:57:35Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-bfdcb83c79c646c799347c6e8ee744932023-12-01T01:33:42ZengMDPI AGDiagnostics2075-44182022-04-0112493110.3390/diagnostics12040931The Diagnostic Dilemma of Urothelial Tissue Fragments in Urinary Tract Cytology SpecimensDerek B. Allison0M. Lisa Zhang1Poonam Vohra2Christopher J. VandenBussche3Department of Pathology and Laboratory Medicine, Lexington, KY 40536, USADepartment of Pathology, Massachusetts General Hospital, Boston, MA 02114, USADepartments of Pathology and Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USADepartments of Pathology and Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USASince the release of The Paris System for Reporting Urinary Cytology (TPS), the assessment of urine cytology specimens has primarily focused on the detection of high-grade urothelial carcinoma (HGUC) and carcinoma in situ (CIS). Fortunately, the malignant cells in these lesions tend to be loosely cohesive, resulting in the natural exfoliation of individual malignant cells into the urine. However, HGUC/CIS lesions occasionally exfoliate larger fragments which can be difficult to assess due to cellular overlap and fragment three-dimensionality. Furthermore, reactive benign urothelial fragments and fragments from low-grade urothelial neoplasms (LGUN) may also be seen in urine specimens and contain atypical cytomorphologic features. As a result, the significance of urothelial tissue fragments (UTFs) is often unclear. Herein, we discuss the literature on UTFs before and after the implementation of TPS, as well as strategies to help overcome this diagnostic challenge.https://www.mdpi.com/2075-4418/12/4/931urinetissue fragmentsbladder cancerlow grade urothelial carcinomaurothelial |
| spellingShingle | Derek B. Allison M. Lisa Zhang Poonam Vohra Christopher J. VandenBussche The Diagnostic Dilemma of Urothelial Tissue Fragments in Urinary Tract Cytology Specimens Diagnostics urine tissue fragments bladder cancer low grade urothelial carcinoma urothelial |
| title | The Diagnostic Dilemma of Urothelial Tissue Fragments in Urinary Tract Cytology Specimens |
| title_full | The Diagnostic Dilemma of Urothelial Tissue Fragments in Urinary Tract Cytology Specimens |
| title_fullStr | The Diagnostic Dilemma of Urothelial Tissue Fragments in Urinary Tract Cytology Specimens |
| title_full_unstemmed | The Diagnostic Dilemma of Urothelial Tissue Fragments in Urinary Tract Cytology Specimens |
| title_short | The Diagnostic Dilemma of Urothelial Tissue Fragments in Urinary Tract Cytology Specimens |
| title_sort | diagnostic dilemma of urothelial tissue fragments in urinary tract cytology specimens |
| topic | urine tissue fragments bladder cancer low grade urothelial carcinoma urothelial |
| url | https://www.mdpi.com/2075-4418/12/4/931 |
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