Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors
Chikungunya and Zika viruses, both transmitted by mosquito vectors, have globally re-emerged over for the last 60 years and resulted in crucial social and economic concerns. Presently, there is no specific antiviral agent or vaccine against these debilitating viruses. Understanding viral–host intera...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/4/448 |
| _version_ | 1827695581979475968 |
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| author | Sineewanlaya Wichit Nuttamonpat Gumpangseth Rodolphe Hamel Sakda Yainoy Siwaret Arikit Chuchard Punsawad Dorothée Missé |
| author_facet | Sineewanlaya Wichit Nuttamonpat Gumpangseth Rodolphe Hamel Sakda Yainoy Siwaret Arikit Chuchard Punsawad Dorothée Missé |
| author_sort | Sineewanlaya Wichit |
| collection | DOAJ |
| description | Chikungunya and Zika viruses, both transmitted by mosquito vectors, have globally re-emerged over for the last 60 years and resulted in crucial social and economic concerns. Presently, there is no specific antiviral agent or vaccine against these debilitating viruses. Understanding viral–host interactions is needed to develop targeted therapeutics. However, there is presently limited information in this area. In this review, we start with the updated virology and replication cycle of each virus. Transmission by similar mosquito vectors, frequent co-circulation, and occurrence of co-infection are summarized. Finally, the targeted host proteins/factors used by the viruses are discussed. There is an urgent need to better understand the virus–host interactions that will facilitate antiviral drug development and thus reduce the global burden of infections caused by arboviruses. |
| first_indexed | 2024-03-10T12:29:17Z |
| format | Article |
| id | doaj.art-bfdda489bd79414f915247978323e608 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T12:29:17Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-bfdda489bd79414f915247978323e6082023-11-21T14:50:20ZengMDPI AGPathogens2076-08172021-04-0110444810.3390/pathogens10040448Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host FactorsSineewanlaya Wichit0Nuttamonpat Gumpangseth1Rodolphe Hamel2Sakda Yainoy3Siwaret Arikit4Chuchard Punsawad5Dorothée Missé6Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, ThailandDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, ThailandMIVEGEC, Univ. Montpellier, CNRS, IRD, Montpellier, FranceDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, ThailandDepartment of Agronomy, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University Kamphaeng Saen Campus, Nakhon Pathom 73140, ThailandSchool of Medicine, Walailak University, Nakhon Si Thammarat 80160, ThailandMIVEGEC, Univ. Montpellier, CNRS, IRD, Montpellier, FranceChikungunya and Zika viruses, both transmitted by mosquito vectors, have globally re-emerged over for the last 60 years and resulted in crucial social and economic concerns. Presently, there is no specific antiviral agent or vaccine against these debilitating viruses. Understanding viral–host interactions is needed to develop targeted therapeutics. However, there is presently limited information in this area. In this review, we start with the updated virology and replication cycle of each virus. Transmission by similar mosquito vectors, frequent co-circulation, and occurrence of co-infection are summarized. Finally, the targeted host proteins/factors used by the viruses are discussed. There is an urgent need to better understand the virus–host interactions that will facilitate antiviral drug development and thus reduce the global burden of infections caused by arboviruses.https://www.mdpi.com/2076-0817/10/4/448Chikungunya virusZika virusantiviralarbovirusarbovirus–host interactions |
| spellingShingle | Sineewanlaya Wichit Nuttamonpat Gumpangseth Rodolphe Hamel Sakda Yainoy Siwaret Arikit Chuchard Punsawad Dorothée Missé Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors Pathogens Chikungunya virus Zika virus antiviral arbovirus arbovirus–host interactions |
| title | Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors |
| title_full | Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors |
| title_fullStr | Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors |
| title_full_unstemmed | Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors |
| title_short | Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors |
| title_sort | chikungunya and zika viruses co circulation and the interplay between viral proteins and host factors |
| topic | Chikungunya virus Zika virus antiviral arbovirus arbovirus–host interactions |
| url | https://www.mdpi.com/2076-0817/10/4/448 |
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