Circular RNAs as Potential Theranostics in the Cardiovascular System
Cardiovascular diseases (CVDs) represent the largest contributor to mortality worldwide. Identification of novel therapeutic targets and biomarkers for CVDs is urgently needed. Circular RNAs (circRNAs) are endogenous, abundant, and stable non-coding RNAs formed by back-splicing events. Their role as...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-12-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S216225311830266X |
| _version_ | 1811334826873061376 |
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| author | Yihua Bei Tingting Yang Lijun Wang Paul Holvoet Saumya Das Joost P.G. Sluijter Marta Chagas Monteiro Yang Liu Qiulian Zhou Junjie Xiao |
| author_facet | Yihua Bei Tingting Yang Lijun Wang Paul Holvoet Saumya Das Joost P.G. Sluijter Marta Chagas Monteiro Yang Liu Qiulian Zhou Junjie Xiao |
| author_sort | Yihua Bei |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) represent the largest contributor to mortality worldwide. Identification of novel therapeutic targets and biomarkers for CVDs is urgently needed. Circular RNAs (circRNAs) are endogenous, abundant, and stable non-coding RNAs formed by back-splicing events. Their role as regulators of gene expression has been increasingly reported. Notably, circRNAs mediate essential physiological and pathological processes in the cardiovascular system. Our first aim, therefore, is to summarize recent advances in the role of circRNAs in cardiac development as well as in pathogenesis of various CVDs. Because circRNAs are stable in circulation and their dynamic changes may reflect different disease stages, they are considered ideal biomarkers. Therefore, our second aim is to review studies that have identified circulating circRNAs as biomarkers for CVDs. Finally, we discuss the shortage of functional studies and the limitations of available clinical studies and provide future perspectives. Keywords: cardiovascular disease, circular RNA, myocardial infarction, heart failure, cardiomyopathy, atherosclerosis, fibrosis, endothelial dysfunction, therapeutic targets, biomarkers |
| first_indexed | 2024-04-13T17:14:56Z |
| format | Article |
| id | doaj.art-bfde537bd2944bcf8e5e7986a5a06b87 |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-04-13T17:14:56Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-bfde537bd2944bcf8e5e7986a5a06b872022-12-22T02:38:10ZengElsevierMolecular Therapy: Nucleic Acids2162-25312018-12-0113407418Circular RNAs as Potential Theranostics in the Cardiovascular SystemYihua Bei0Tingting Yang1Lijun Wang2Paul Holvoet3Saumya Das4Joost P.G. Sluijter5Marta Chagas Monteiro6Yang Liu7Qiulian Zhou8Junjie Xiao9Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, ChinaCardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, ChinaCardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, ChinaDepartment of Cardiovascular Sciences, Experimental Cardiology, KU Leuven, 3000 Leuven, BelgiumCardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USADepartment of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands; UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, Utrecht 3508GA, the NetherlandsPharmaceutical Science Post-Graduation Program, Health Science Institute, Federal University of Pará/UFPA, Belém, PA 66075900, BrazilDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, ChinaCardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, ChinaCardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China; Corresponding author: Junjie Xiao, Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai 200444, China.Cardiovascular diseases (CVDs) represent the largest contributor to mortality worldwide. Identification of novel therapeutic targets and biomarkers for CVDs is urgently needed. Circular RNAs (circRNAs) are endogenous, abundant, and stable non-coding RNAs formed by back-splicing events. Their role as regulators of gene expression has been increasingly reported. Notably, circRNAs mediate essential physiological and pathological processes in the cardiovascular system. Our first aim, therefore, is to summarize recent advances in the role of circRNAs in cardiac development as well as in pathogenesis of various CVDs. Because circRNAs are stable in circulation and their dynamic changes may reflect different disease stages, they are considered ideal biomarkers. Therefore, our second aim is to review studies that have identified circulating circRNAs as biomarkers for CVDs. Finally, we discuss the shortage of functional studies and the limitations of available clinical studies and provide future perspectives. Keywords: cardiovascular disease, circular RNA, myocardial infarction, heart failure, cardiomyopathy, atherosclerosis, fibrosis, endothelial dysfunction, therapeutic targets, biomarkershttp://www.sciencedirect.com/science/article/pii/S216225311830266X |
| spellingShingle | Yihua Bei Tingting Yang Lijun Wang Paul Holvoet Saumya Das Joost P.G. Sluijter Marta Chagas Monteiro Yang Liu Qiulian Zhou Junjie Xiao Circular RNAs as Potential Theranostics in the Cardiovascular System Molecular Therapy: Nucleic Acids |
| title | Circular RNAs as Potential Theranostics in the Cardiovascular System |
| title_full | Circular RNAs as Potential Theranostics in the Cardiovascular System |
| title_fullStr | Circular RNAs as Potential Theranostics in the Cardiovascular System |
| title_full_unstemmed | Circular RNAs as Potential Theranostics in the Cardiovascular System |
| title_short | Circular RNAs as Potential Theranostics in the Cardiovascular System |
| title_sort | circular rnas as potential theranostics in the cardiovascular system |
| url | http://www.sciencedirect.com/science/article/pii/S216225311830266X |
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