Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes
RNA synthesis in respiratory syncytial virus (RSV), a negative-sense (−) nonsegmented RNA virus, consists of viral gene transcription and genome replication. Gene transcription includes the positive-sense (+) viral mRNA synthesis, 5′-RNA capping and methylation, and 3′ end polyadenylation. Genome re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/5/834 |
| _version_ | 1797535241595781120 |
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| author | Dongdong Cao Yunrong Gao Bo Liang |
| author_facet | Dongdong Cao Yunrong Gao Bo Liang |
| author_sort | Dongdong Cao |
| collection | DOAJ |
| description | RNA synthesis in respiratory syncytial virus (RSV), a negative-sense (−) nonsegmented RNA virus, consists of viral gene transcription and genome replication. Gene transcription includes the positive-sense (+) viral mRNA synthesis, 5′-RNA capping and methylation, and 3′ end polyadenylation. Genome replication includes (+) RNA antigenome and (−) RNA genome synthesis. RSV executes the viral RNA synthesis using an RNA synthesis ribonucleoprotein (RNP) complex, comprising four proteins, the nucleoprotein (N), the large protein (L), the phosphoprotein (P), and the M2-1 protein. We provide an overview of the RSV RNA synthesis and the structural insights into the RSV gene transcription and genome replication process. We propose a model of how the essential four proteins coordinate their activities in different RNA synthesis processes. |
| first_indexed | 2024-03-10T11:41:45Z |
| format | Article |
| id | doaj.art-bfdf6ab89dfd4c30a086b78e1b2af550 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T11:41:45Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-bfdf6ab89dfd4c30a086b78e1b2af5502023-11-21T18:26:58ZengMDPI AGViruses1999-49152021-05-0113583410.3390/v13050834Structural Insights into the Respiratory Syncytial Virus RNA Synthesis ComplexesDongdong Cao0Yunrong Gao1Bo Liang2Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USARNA synthesis in respiratory syncytial virus (RSV), a negative-sense (−) nonsegmented RNA virus, consists of viral gene transcription and genome replication. Gene transcription includes the positive-sense (+) viral mRNA synthesis, 5′-RNA capping and methylation, and 3′ end polyadenylation. Genome replication includes (+) RNA antigenome and (−) RNA genome synthesis. RSV executes the viral RNA synthesis using an RNA synthesis ribonucleoprotein (RNP) complex, comprising four proteins, the nucleoprotein (N), the large protein (L), the phosphoprotein (P), and the M2-1 protein. We provide an overview of the RSV RNA synthesis and the structural insights into the RSV gene transcription and genome replication process. We propose a model of how the essential four proteins coordinate their activities in different RNA synthesis processes.https://www.mdpi.com/1999-4915/13/5/834structurerespiratory syncytial virusRNA synthesisgene transcriptiongenome replicationN, L, P, and M2-1 |
| spellingShingle | Dongdong Cao Yunrong Gao Bo Liang Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes Viruses structure respiratory syncytial virus RNA synthesis gene transcription genome replication N, L, P, and M2-1 |
| title | Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes |
| title_full | Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes |
| title_fullStr | Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes |
| title_full_unstemmed | Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes |
| title_short | Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes |
| title_sort | structural insights into the respiratory syncytial virus rna synthesis complexes |
| topic | structure respiratory syncytial virus RNA synthesis gene transcription genome replication N, L, P, and M2-1 |
| url | https://www.mdpi.com/1999-4915/13/5/834 |
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