Nano‐LYTACs for Degradation of Membrane Proteins and Inhibition of CD24/Siglec‐10 Signaling Pathway

Nano‐LYTACs for Degradation of Membrane Proteins and Inhibition of CD24/Siglec‐10 Signaling Pathway

Show other versions (1)

Abstract Lysosome‐targeting chimeras (LYTACs) are an emerging therapeutic modality that effectively degrade cancer cell membranes and extracellular target proteins. In this study, a nanosphere‐based LYTAC degradation system is developed. The amphiphilic peptide‐modified N‐acetylgalactosamine (GalNAc...

Full description

Bibliographic Details
Main Authors: Kun Wang, Albert Yu, Kewei Liu, Chunyan Feng, Yibo Hou, Jiawei Chen, Shaohua Ma, Laiqiang Huang, Xiaoyong Dai
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
ASGPR
CD24
GOx
liver cancer
lysosomal degradation
LYTACs
Online Access:https://doi.org/10.1002/advs.202300288

Internet

https://doi.org/10.1002/advs.202300288

Similar Items