Vasoconstrictor antagonism improves functional and structural vascular alterations and liver damage in rats with early NAFLD

Vasoconstrictor antagonism improves functional and structural vascular alterations and liver damage in rats with early NAFLD

Background & Aims: Intrahepatic vascular resistance is increased in early non-alcoholic fatty liver disease (NAFLD), potentially leading to tissue hypoxia and triggering disease progression. Hepatic vascular hyperreactivity to vasoconstrictors has been identified as an underlying mechanism....

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Bibliographic Details
Main Authors: Denise van der Graaff, Shivani Chotkoe, Benedicte De Winter, Joris De Man, Christophe Casteleyn, Jean-Pierre Timmermans, Isabel Pintelon, Luisa Vonghia, Wilhelmus J. Kwanten, Sven Francque
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:JHEP Reports
Subjects:
non-alcoholic fatty liver disease
transhepatic pressure gradient
portal hypertension
endothelin-1
thromboxane A2
angiotensin II
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921001889

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