Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia

BK virus (BKV) and JC virus (JCV) persist as latent infection in the kidneys. Reactivation of both viruses may be linked to immunodeficiency. The aims of this study were to determine the prevalence of BKV and JCV viruria and to evaluate the relationship between immunodeficiency and viruria...

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Main Authors: Karalić Danijela, Lazarević Ivana, Ćupić Maja, Jevtović Đ., Jovanović Tanja
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2014-01-01
Series:Archives of Biological Sciences
Subjects:
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402609K.pdf
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author Karalić Danijela
Lazarević Ivana
Ćupić Maja
Jevtović Đ.
Jovanović Tanja
author_facet Karalić Danijela
Lazarević Ivana
Ćupić Maja
Jevtović Đ.
Jovanović Tanja
author_sort Karalić Danijela
collection DOAJ
description BK virus (BKV) and JC virus (JCV) persist as latent infection in the kidneys. Reactivation of both viruses may be linked to immunodeficiency. The aims of this study were to determine the prevalence of BKV and JCV viruria and to evaluate the relationship between immunodeficiency and viruria in a cohort of HIV-infected patients. Urine samples from 93 HIV-infected patients were collected and tested for the presence of BKV and JCV DNA by PCR. The overall prevalence of polyomavirus DNA in urine was 74.2%. BKV DNA was detected in 30.1% urine samples and JCV DNA in 23.7% samples. Both BKV and JCV DNA were detected in 20.4% samples. There was no association between BKV/JCV urinary shedding and the degree of immunosuppression measured by CD4+ cell count. However, taking into account the severity of disease resulting from reactivation of BKV and JCV, patients with HIV/polyomavirus co-infection should be kept under frequent and regular supervision. [Projekat Ministarstva nauke Republike Srbije, br. 175073]
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spelling doaj.art-bfe074b1ec70426b98fcf9f02b4a75622022-12-21T18:10:22ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392014-01-0166260961410.2298/ABS1402609K0354-46641402609KPrevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from SerbiaKaralić Danijela0Lazarević Ivana1Ćupić Maja2Jevtović Đ.3Jovanović Tanja4Faculty of Medicine, Institute of Microbiology and Immunology, BelgradeFaculty of Medicine, Institute of Microbiology and Immunology, BelgradeFaculty of Medicine, Institute of Microbiology and Immunology, BelgradeFaculty of Medicine, Clinical Center of Serbia, Clinic of Infectious and Tropical Diseases, BelgradeFaculty of Medicine, Institute of Microbiology and Immunology, BelgradeBK virus (BKV) and JC virus (JCV) persist as latent infection in the kidneys. Reactivation of both viruses may be linked to immunodeficiency. The aims of this study were to determine the prevalence of BKV and JCV viruria and to evaluate the relationship between immunodeficiency and viruria in a cohort of HIV-infected patients. Urine samples from 93 HIV-infected patients were collected and tested for the presence of BKV and JCV DNA by PCR. The overall prevalence of polyomavirus DNA in urine was 74.2%. BKV DNA was detected in 30.1% urine samples and JCV DNA in 23.7% samples. Both BKV and JCV DNA were detected in 20.4% samples. There was no association between BKV/JCV urinary shedding and the degree of immunosuppression measured by CD4+ cell count. However, taking into account the severity of disease resulting from reactivation of BKV and JCV, patients with HIV/polyomavirus co-infection should be kept under frequent and regular supervision. [Projekat Ministarstva nauke Republike Srbije, br. 175073]http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402609K.pdfJC virusBK virusHIV-infectionimmunosuppressionurinary excretion
spellingShingle Karalić Danijela
Lazarević Ivana
Ćupić Maja
Jevtović Đ.
Jovanović Tanja
Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia
Archives of Biological Sciences
JC virus
BK virus
HIV-infection
immunosuppression
urinary excretion
title Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia
title_full Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia
title_fullStr Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia
title_full_unstemmed Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia
title_short Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia
title_sort prevalence of jc and bk polyomavirus excretion in the urine of hiv infected patients from serbia
topic JC virus
BK virus
HIV-infection
immunosuppression
urinary excretion
url http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402609K.pdf
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