Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia
BK virus (BKV) and JC virus (JCV) persist as latent infection in the kidneys. Reactivation of both viruses may be linked to immunodeficiency. The aims of this study were to determine the prevalence of BKV and JCV viruria and to evaluate the relationship between immunodeficiency and viruria...
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Format: | Article |
Language: | English |
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University of Belgrade, University of Novi Sad
2014-01-01
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Series: | Archives of Biological Sciences |
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Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402609K.pdf |
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author | Karalić Danijela Lazarević Ivana Ćupić Maja Jevtović Đ. Jovanović Tanja |
author_facet | Karalić Danijela Lazarević Ivana Ćupić Maja Jevtović Đ. Jovanović Tanja |
author_sort | Karalić Danijela |
collection | DOAJ |
description | BK virus (BKV) and JC virus (JCV) persist as latent infection in the kidneys.
Reactivation of both viruses may be linked to immunodeficiency. The aims of
this study were to determine the prevalence of BKV and JCV viruria and to
evaluate the relationship between immunodeficiency and viruria in a cohort of
HIV-infected patients. Urine samples from 93 HIV-infected patients were
collected and tested for the presence of BKV and JCV DNA by PCR. The overall
prevalence of polyomavirus DNA in urine was 74.2%. BKV DNA was detected in
30.1% urine samples and JCV DNA in 23.7% samples. Both BKV and JCV DNA were
detected in 20.4% samples. There was no association between BKV/JCV urinary
shedding and the degree of immunosuppression measured by CD4+ cell count.
However, taking into account the severity of disease resulting from
reactivation of BKV and JCV, patients with HIV/polyomavirus co-infection
should be kept under frequent and regular supervision. [Projekat Ministarstva
nauke Republike Srbije, br. 175073] |
first_indexed | 2024-12-22T22:33:20Z |
format | Article |
id | doaj.art-bfe074b1ec70426b98fcf9f02b4a7562 |
institution | Directory Open Access Journal |
issn | 0354-4664 1821-4339 |
language | English |
last_indexed | 2024-12-22T22:33:20Z |
publishDate | 2014-01-01 |
publisher | University of Belgrade, University of Novi Sad |
record_format | Article |
series | Archives of Biological Sciences |
spelling | doaj.art-bfe074b1ec70426b98fcf9f02b4a75622022-12-21T18:10:22ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392014-01-0166260961410.2298/ABS1402609K0354-46641402609KPrevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from SerbiaKaralić Danijela0Lazarević Ivana1Ćupić Maja2Jevtović Đ.3Jovanović Tanja4Faculty of Medicine, Institute of Microbiology and Immunology, BelgradeFaculty of Medicine, Institute of Microbiology and Immunology, BelgradeFaculty of Medicine, Institute of Microbiology and Immunology, BelgradeFaculty of Medicine, Clinical Center of Serbia, Clinic of Infectious and Tropical Diseases, BelgradeFaculty of Medicine, Institute of Microbiology and Immunology, BelgradeBK virus (BKV) and JC virus (JCV) persist as latent infection in the kidneys. Reactivation of both viruses may be linked to immunodeficiency. The aims of this study were to determine the prevalence of BKV and JCV viruria and to evaluate the relationship between immunodeficiency and viruria in a cohort of HIV-infected patients. Urine samples from 93 HIV-infected patients were collected and tested for the presence of BKV and JCV DNA by PCR. The overall prevalence of polyomavirus DNA in urine was 74.2%. BKV DNA was detected in 30.1% urine samples and JCV DNA in 23.7% samples. Both BKV and JCV DNA were detected in 20.4% samples. There was no association between BKV/JCV urinary shedding and the degree of immunosuppression measured by CD4+ cell count. However, taking into account the severity of disease resulting from reactivation of BKV and JCV, patients with HIV/polyomavirus co-infection should be kept under frequent and regular supervision. [Projekat Ministarstva nauke Republike Srbije, br. 175073]http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402609K.pdfJC virusBK virusHIV-infectionimmunosuppressionurinary excretion |
spellingShingle | Karalić Danijela Lazarević Ivana Ćupić Maja Jevtović Đ. Jovanović Tanja Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia Archives of Biological Sciences JC virus BK virus HIV-infection immunosuppression urinary excretion |
title | Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia |
title_full | Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia |
title_fullStr | Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia |
title_full_unstemmed | Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia |
title_short | Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia |
title_sort | prevalence of jc and bk polyomavirus excretion in the urine of hiv infected patients from serbia |
topic | JC virus BK virus HIV-infection immunosuppression urinary excretion |
url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402609K.pdf |
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