The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients

The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients

Temporal lobe epilepsy (TLE) is the most common type of partial epilepsy referred for surgery due to antiepileptic drug (AED) resistance. A common molecular target for many of these drugs is the voltage-gated sodium channel (VGSC). The VGSC consists of four domains of pore-forming α-subunits and two...

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Bibliographic Details
Main Authors: Mariam A. Sheilabi, Louise Y. Takeshita, Edward J. Sims, Francesco Falciani, Alessandra P. Princivalle
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
temporal lobe epilepsy
hippocampal sclerosis
antiepileptic drug resistance
<i>SCN4B</i>
voltage-gated sodium channels
Nav β4 subunit
Online Access:https://www.mdpi.com/1422-0067/21/8/2955

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