Central neural circuitry mediating courtship song perception in male Drosophila
Animals use acoustic signals across a variety of social behaviors, particularly courtship. In Drosophila, song is detected by antennal mechanosensory neurons and further processed by second-order aPN1/aLN(al) neurons. However, little is known about the central pathways mediating courtship hearing. I...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2015-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/08477 |
| _version_ | 1828375362731507712 |
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| author | Chuan Zhou Romain Franconville Alexander G Vaughan Carmen C Robinett Vivek Jayaraman Bruce S Baker |
| author_facet | Chuan Zhou Romain Franconville Alexander G Vaughan Carmen C Robinett Vivek Jayaraman Bruce S Baker |
| author_sort | Chuan Zhou |
| collection | DOAJ |
| description | Animals use acoustic signals across a variety of social behaviors, particularly courtship. In Drosophila, song is detected by antennal mechanosensory neurons and further processed by second-order aPN1/aLN(al) neurons. However, little is known about the central pathways mediating courtship hearing. In this study, we identified a male-specific pathway for courtship hearing via third-order ventrolateral protocerebrum Projection Neuron 1 (vPN1) neurons and fourth-order pC1 neurons. Genetic inactivation of vPN1 or pC1 disrupts song-induced male-chaining behavior. Calcium imaging reveals that vPN1 responds preferentially to pulse song with long inter-pulse intervals (IPIs), while pC1 responses to pulse song closely match the behavioral chaining responses at different IPIs. Moreover, genetic activation of either vPN1 or pC1 induced courtship chaining, mimicking the behavioral response to song. These results outline the aPN1-vPN1-pC1 pathway as a labeled line for the processing and transformation of courtship song in males. |
| first_indexed | 2024-04-14T07:45:28Z |
| format | Article |
| id | doaj.art-bfe49d5920634539b71faa46d9a4577c |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:45:28Z |
| publishDate | 2015-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-bfe49d5920634539b71faa46d9a4577c2022-12-22T02:05:21ZengeLife Sciences Publications LtdeLife2050-084X2015-09-01410.7554/eLife.08477Central neural circuitry mediating courtship song perception in male DrosophilaChuan Zhou0Romain Franconville1Alexander G Vaughan2Carmen C Robinett3Vivek Jayaraman4Bruce S Baker5Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesCold Spring Harbor Laboratory, New York, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesAnimals use acoustic signals across a variety of social behaviors, particularly courtship. In Drosophila, song is detected by antennal mechanosensory neurons and further processed by second-order aPN1/aLN(al) neurons. However, little is known about the central pathways mediating courtship hearing. In this study, we identified a male-specific pathway for courtship hearing via third-order ventrolateral protocerebrum Projection Neuron 1 (vPN1) neurons and fourth-order pC1 neurons. Genetic inactivation of vPN1 or pC1 disrupts song-induced male-chaining behavior. Calcium imaging reveals that vPN1 responds preferentially to pulse song with long inter-pulse intervals (IPIs), while pC1 responses to pulse song closely match the behavioral chaining responses at different IPIs. Moreover, genetic activation of either vPN1 or pC1 induced courtship chaining, mimicking the behavioral response to song. These results outline the aPN1-vPN1-pC1 pathway as a labeled line for the processing and transformation of courtship song in males.https://elifesciences.org/articles/08477courtshipcourtship songauditory sensation |
| spellingShingle | Chuan Zhou Romain Franconville Alexander G Vaughan Carmen C Robinett Vivek Jayaraman Bruce S Baker Central neural circuitry mediating courtship song perception in male Drosophila eLife courtship courtship song auditory sensation |
| title | Central neural circuitry mediating courtship song perception in male Drosophila |
| title_full | Central neural circuitry mediating courtship song perception in male Drosophila |
| title_fullStr | Central neural circuitry mediating courtship song perception in male Drosophila |
| title_full_unstemmed | Central neural circuitry mediating courtship song perception in male Drosophila |
| title_short | Central neural circuitry mediating courtship song perception in male Drosophila |
| title_sort | central neural circuitry mediating courtship song perception in male drosophila |
| topic | courtship courtship song auditory sensation |
| url | https://elifesciences.org/articles/08477 |
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