Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation
<p>Abstract</p> <p>Background</p> <p>Liver × receptor α (LXRα) and β (LXRβ) are members of the nuclear receptor super family of ligand-activated transcription factors, a super family which includes the perhaps better known glucocorticoid receptor, estrogen receptor, thy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-02-01
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| Series: | Respiratory Research |
| Online Access: | http://respiratory-research.com/content/11/1/19 |
| _version_ | 1818472692249001984 |
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| author | Bramanti Placido Galuppo Maria Paterniti Irene Mazzon Emanuela Crisafulli Concetta Cuzzocrea Salvatore |
| author_facet | Bramanti Placido Galuppo Maria Paterniti Irene Mazzon Emanuela Crisafulli Concetta Cuzzocrea Salvatore |
| author_sort | Bramanti Placido |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Liver × receptor α (LXRα) and β (LXRβ) are members of the nuclear receptor super family of ligand-activated transcription factors, a super family which includes the perhaps better known glucocorticoid receptor, estrogen receptor, thyroid receptor, and peroxisome proliferator-activated receptors. There is limited evidence that LXL activation may reduces acute lung inflammation. The aim of this study was to investigate the effects of T0901317, a potent LXR receptor ligand, in a mouse model of carrageenan-induced pleurisy.</p> <p>Methods</p> <p>Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NOx), tumor necrosis factor-α, (TNF-α) and interleukin-1β (IL-1β). Furthermore, carrageenan induced the expression of iNOS, nitrotyrosine and PARP, as well as induced apoptosis (TUNEL staining and Bax and Bcl-2 expression) in the lung tissues.</p> <p>Results</p> <p>Administration of T0901317, 30 min after the challenge with carrageenan, caused a significant reduction in a dose dependent manner of all the parameters of inflammation measured.</p> <p>Conclusions</p> <p>Thus, based on these findings we propose that LXR ligand such as T0901317, may be useful in the treatment of various inflammatory diseases.</p> |
| first_indexed | 2024-04-14T04:12:05Z |
| format | Article |
| id | doaj.art-bfe4a962e1344cffa652b8434aa581de |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-04-14T04:12:05Z |
| publishDate | 2010-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-bfe4a962e1344cffa652b8434aa581de2022-12-22T02:13:07ZengBMCRespiratory Research1465-99212010-02-011111910.1186/1465-9921-11-19Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammationBramanti PlacidoGaluppo MariaPaterniti IreneMazzon EmanuelaCrisafulli ConcettaCuzzocrea Salvatore<p>Abstract</p> <p>Background</p> <p>Liver × receptor α (LXRα) and β (LXRβ) are members of the nuclear receptor super family of ligand-activated transcription factors, a super family which includes the perhaps better known glucocorticoid receptor, estrogen receptor, thyroid receptor, and peroxisome proliferator-activated receptors. There is limited evidence that LXL activation may reduces acute lung inflammation. The aim of this study was to investigate the effects of T0901317, a potent LXR receptor ligand, in a mouse model of carrageenan-induced pleurisy.</p> <p>Methods</p> <p>Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NOx), tumor necrosis factor-α, (TNF-α) and interleukin-1β (IL-1β). Furthermore, carrageenan induced the expression of iNOS, nitrotyrosine and PARP, as well as induced apoptosis (TUNEL staining and Bax and Bcl-2 expression) in the lung tissues.</p> <p>Results</p> <p>Administration of T0901317, 30 min after the challenge with carrageenan, caused a significant reduction in a dose dependent manner of all the parameters of inflammation measured.</p> <p>Conclusions</p> <p>Thus, based on these findings we propose that LXR ligand such as T0901317, may be useful in the treatment of various inflammatory diseases.</p>http://respiratory-research.com/content/11/1/19 |
| spellingShingle | Bramanti Placido Galuppo Maria Paterniti Irene Mazzon Emanuela Crisafulli Concetta Cuzzocrea Salvatore Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation Respiratory Research |
| title | Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation |
| title_full | Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation |
| title_fullStr | Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation |
| title_full_unstemmed | Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation |
| title_short | Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation |
| title_sort | effects of liver receptor agonist treatment on signal transduction pathways in acute lung inflammation |
| url | http://respiratory-research.com/content/11/1/19 |
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