Synergistic effects of angiotensinogen −217 G→A and T704C (M235T) variants on the risk of severe preeclampsia
Background: The rate-limiting step of the renin–angiotensin system is the enzymatic cleavage of angiotensinogen (AGT) by renin. The aims of the present study were to investigate the association between AGT T704C (M235T) and −217 G→A polymorphisms with the risk of preeclampsia and synergistic effects...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2014-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320312467555 |
| _version_ | 1797288521725116416 |
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| author | Farhad Shahvaisizadeh Abolfazl Movafagh Mir Davood Omrani Asad Vaisi-Raygani Ziba Rahimi Zohreh Rahimi |
| author_facet | Farhad Shahvaisizadeh Abolfazl Movafagh Mir Davood Omrani Asad Vaisi-Raygani Ziba Rahimi Zohreh Rahimi |
| author_sort | Farhad Shahvaisizadeh |
| collection | DOAJ |
| description | Background: The rate-limiting step of the renin–angiotensin system is the enzymatic cleavage of angiotensinogen (AGT) by renin. The aims of the present study were to investigate the association between AGT T704C (M235T) and −217 G→A polymorphisms with the risk of preeclampsia and synergistic effects of both polymorphisms on the susceptibility to preeclampsia. Methods: We studied AGT variants in 170 women with preeclampsia, including 84 women with mild and 86 women with severe forms of preeclampsia, and 100 age and parity matched controls. Results: There was a trend towards increased risk of severe preeclampsia in the presence of −217 AA (odds ratio (OR)=1.5, 95% confidence interval (CI)= 0.38–5.84, p =0.57) and TC+CC genotypes (OR=1.32, 95% CI= 0.67–2.58, p =0.42). However, the interaction of both alleles of −217A and 704C highly increased the risk of severe preeclampsia, by 2.23-fold, although this did not reach statistical significance. The frequency of the CC genotype of the T704C polymorphism in early-onset preeclampsia tended to be higher (35%) compared with that in patients with late-onset preeclampsia (21.7%). Conclusions: The present study demonstrates that both variants of AGT −217 G→A and T704C might work in synergism to influence the risk of severe preeclampsia, which needs to be confirmed in studies with larger sample size. |
| first_indexed | 2024-03-07T18:50:42Z |
| format | Article |
| id | doaj.art-bfe4bbf6121d4eb09cd3b962f62edeee |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:50:42Z |
| publishDate | 2014-06-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-bfe4bbf6121d4eb09cd3b962f62edeee2024-03-02T01:47:58ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762014-06-011510.1177/1470320312467555Synergistic effects of angiotensinogen −217 G→A and T704C (M235T) variants on the risk of severe preeclampsiaFarhad Shahvaisizadeh0Abolfazl Movafagh1Mir Davood Omrani2Asad Vaisi-Raygani3Ziba Rahimi4Zohreh Rahimi5Department of Medical Genetics, Medical School, Shahid Beheshti University of Medical Sciences, IranDepartment of Medical Genetics, Medical School, Shahid Beheshti University of Medical Sciences, IranDepartment of Medical Genetics, Medical School, Shahid Beheshti University of Medical Sciences, IranDepartment of Biochemistry, Medical School, Kermanshah University of Medical Sciences, IranMedical Biology Research Center, Kermanshah University of Medical Sciences, IranMedical Biology Research Center, Kermanshah University of Medical Sciences, IranBackground: The rate-limiting step of the renin–angiotensin system is the enzymatic cleavage of angiotensinogen (AGT) by renin. The aims of the present study were to investigate the association between AGT T704C (M235T) and −217 G→A polymorphisms with the risk of preeclampsia and synergistic effects of both polymorphisms on the susceptibility to preeclampsia. Methods: We studied AGT variants in 170 women with preeclampsia, including 84 women with mild and 86 women with severe forms of preeclampsia, and 100 age and parity matched controls. Results: There was a trend towards increased risk of severe preeclampsia in the presence of −217 AA (odds ratio (OR)=1.5, 95% confidence interval (CI)= 0.38–5.84, p =0.57) and TC+CC genotypes (OR=1.32, 95% CI= 0.67–2.58, p =0.42). However, the interaction of both alleles of −217A and 704C highly increased the risk of severe preeclampsia, by 2.23-fold, although this did not reach statistical significance. The frequency of the CC genotype of the T704C polymorphism in early-onset preeclampsia tended to be higher (35%) compared with that in patients with late-onset preeclampsia (21.7%). Conclusions: The present study demonstrates that both variants of AGT −217 G→A and T704C might work in synergism to influence the risk of severe preeclampsia, which needs to be confirmed in studies with larger sample size.https://doi.org/10.1177/1470320312467555 |
| spellingShingle | Farhad Shahvaisizadeh Abolfazl Movafagh Mir Davood Omrani Asad Vaisi-Raygani Ziba Rahimi Zohreh Rahimi Synergistic effects of angiotensinogen −217 G→A and T704C (M235T) variants on the risk of severe preeclampsia Journal of the Renin-Angiotensin-Aldosterone System |
| title | Synergistic effects of angiotensinogen −217 G→A and T704C (M235T) variants on the risk of severe preeclampsia |
| title_full | Synergistic effects of angiotensinogen −217 G→A and T704C (M235T) variants on the risk of severe preeclampsia |
| title_fullStr | Synergistic effects of angiotensinogen −217 G→A and T704C (M235T) variants on the risk of severe preeclampsia |
| title_full_unstemmed | Synergistic effects of angiotensinogen −217 G→A and T704C (M235T) variants on the risk of severe preeclampsia |
| title_short | Synergistic effects of angiotensinogen −217 G→A and T704C (M235T) variants on the risk of severe preeclampsia |
| title_sort | synergistic effects of angiotensinogen 217 g a and t704c m235t variants on the risk of severe preeclampsia |
| url | https://doi.org/10.1177/1470320312467555 |
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