Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6
Abstract Extraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non‐pathogens acquire virulence traits and emerge as pathogens. However, diarrheagenic...
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| Format: | Article |
| Language: | English |
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Springer Nature
2014-03-01
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| Series: | EMBO Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/emmm.201303133 |
| _version_ | 1797281903198339072 |
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| author | Martina Bielaszewska Roswitha Schiller Lydia Lammers Andreas Bauwens Angelika Fruth Barbara Middendorf M Alexander Schmidt Phillip I Tarr Ulrich Dobrindt Helge Karch Alexander Mellmann |
| author_facet | Martina Bielaszewska Roswitha Schiller Lydia Lammers Andreas Bauwens Angelika Fruth Barbara Middendorf M Alexander Schmidt Phillip I Tarr Ulrich Dobrindt Helge Karch Alexander Mellmann |
| author_sort | Martina Bielaszewska |
| collection | DOAJ |
| description | Abstract Extraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non‐pathogens acquire virulence traits and emerge as pathogens. However, diarrheagenic Shiga toxin‐producing E. coli (STEC) O2:H6 not only possess and express virulence factors associated with diarrheagenic and uropathogenic E. coli but also cause diarrhea and urinary tract infections. These organisms are phylogenetically positioned between members of an intestinal pathogenic group (STEC) and extraintestinal pathogenic E. coli. STEC O2:H6 is, therefore, a ‘heteropathogen,’ and the first such hybrid virulent E. coli identified. The phylogeny of these E. coli and the repertoire of virulence traits they possess compel consideration of an alternate view of pathogen emergence, whereby one pathogroup of E. coli undergoes phased metamorphosis into another. By understanding the evolutionary mechanisms of bacterial pathogens, rational strategies for counteracting their detrimental effects on humans can be developed. |
| first_indexed | 2024-03-07T17:04:10Z |
| format | Article |
| id | doaj.art-bfe514cde49048e19795156d2bd858ec |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2024-03-07T17:04:10Z |
| publishDate | 2014-03-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-bfe514cde49048e19795156d2bd858ec2024-03-03T02:52:04ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842014-03-016334735710.1002/emmm.201303133Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6Martina Bielaszewska0Roswitha Schiller1Lydia Lammers2Andreas Bauwens3Angelika Fruth4Barbara Middendorf5M Alexander Schmidt6Phillip I Tarr7Ulrich Dobrindt8Helge Karch9Alexander Mellmann10Institute of Hygiene University of Münster Münster GermanyInstitute of Hygiene University of Münster Münster GermanyInstitute of Hygiene University of Münster Münster GermanyInstitute of Hygiene University of Münster Münster GermanyNational Reference Center for Salmonella and Other Bacterial Enteric Pathogens Robert Koch Institute Wernigerode GermanyInstitute of Hygiene University of Münster Münster GermanyNInstitute of Infectiology Center for Molecular Biology of Inflammation (ZMBE) University of Münster Münster GermanyDepartment of Pediatrics Washington University School of Medicine Saint Louis MO USAInstitute of Hygiene University of Münster Münster GermanyInstitute of Hygiene University of Münster Münster GermanyInstitute of Hygiene University of Münster Münster GermanyAbstract Extraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non‐pathogens acquire virulence traits and emerge as pathogens. However, diarrheagenic Shiga toxin‐producing E. coli (STEC) O2:H6 not only possess and express virulence factors associated with diarrheagenic and uropathogenic E. coli but also cause diarrhea and urinary tract infections. These organisms are phylogenetically positioned between members of an intestinal pathogenic group (STEC) and extraintestinal pathogenic E. coli. STEC O2:H6 is, therefore, a ‘heteropathogen,’ and the first such hybrid virulent E. coli identified. The phylogeny of these E. coli and the repertoire of virulence traits they possess compel consideration of an alternate view of pathogen emergence, whereby one pathogroup of E. coli undergoes phased metamorphosis into another. By understanding the evolutionary mechanisms of bacterial pathogens, rational strategies for counteracting their detrimental effects on humans can be developed.https://doi.org/10.1002/emmm.201303133heteropathogenicityphased metamorphosisphylogenyShiga toxin‐producing Escherichia coliuropathogenic Escherichia coli |
| spellingShingle | Martina Bielaszewska Roswitha Schiller Lydia Lammers Andreas Bauwens Angelika Fruth Barbara Middendorf M Alexander Schmidt Phillip I Tarr Ulrich Dobrindt Helge Karch Alexander Mellmann Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6 EMBO Molecular Medicine heteropathogenicity phased metamorphosis phylogeny Shiga toxin‐producing Escherichia coli uropathogenic Escherichia coli |
| title | Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6 |
| title_full | Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6 |
| title_fullStr | Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6 |
| title_full_unstemmed | Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6 |
| title_short | Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6 |
| title_sort | heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in escherichia coli o2 h6 |
| topic | heteropathogenicity phased metamorphosis phylogeny Shiga toxin‐producing Escherichia coli uropathogenic Escherichia coli |
| url | https://doi.org/10.1002/emmm.201303133 |
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