Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis
For the early detection of atherosclerosis, it is imperative to explore the capabilities of new, effective noninvasive diagnosis techniques to significantly reduce the associated treatment costs and mortality rates. In this study, a multifaceted comprehensive approach involving advanced computationa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/8/3/34 |
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| author | Fardin Khalili Peshala T. Gamage Amirtahà Taebi Mark E. Johnson Randal B. Roberts John Mitchel |
| author_facet | Fardin Khalili Peshala T. Gamage Amirtahà Taebi Mark E. Johnson Randal B. Roberts John Mitchel |
| author_sort | Fardin Khalili |
| collection | DOAJ |
| description | For the early detection of atherosclerosis, it is imperative to explore the capabilities of new, effective noninvasive diagnosis techniques to significantly reduce the associated treatment costs and mortality rates. In this study, a multifaceted comprehensive approach involving advanced computational fluid dynamics combined with signal processing techniques was exploited to investigate the highly turbulent fluctuating flow through arterial stenosis. The focus was on localizing high-energy mechano-acoustic source potential to transmit to the epidermal surface. The flow analysis results showed the existence of turbulent pressure fluctuations inside the stenosis and in the post-stenotic region. After analyzing the turbulent kinetic energy and pressure fluctuations on the flow centerline and the vessel wall, the point of maximum excitation in the flow was observed around two diameters downstream of the stenosis within the fluctuating zone. It was also found that the concentration of pressure fluctuation closer to the wall was higher inside the stenosis compared to the post-stenotic region. Additionally, the visualization of the most energetic proper orthogonal decomposition (POD) mode and spectral decomposition of the flow indicated that the break frequencies ranged from 80 to 220 Hz and were correlated to the eddies generated within these regions. |
| first_indexed | 2024-03-09T05:29:38Z |
| format | Article |
| id | doaj.art-bfe99fd7b84a4c488b55e50ca6840aa5 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T05:29:38Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-bfe99fd7b84a4c488b55e50ca6840aa52023-12-03T12:34:09ZengMDPI AGBioengineering2306-53542021-03-01833410.3390/bioengineering8030034Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial StenosisFardin Khalili0Peshala T. Gamage1Amirtahà Taebi2Mark E. Johnson3Randal B. Roberts4John Mitchel5Department of Mechanical Engineering, Embry-Riddle Aeronautical University, 1 Aerospace Boulevard, Daytona Beach, FL 32114, USADepartment of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, 2930 Science Cir., Melbourne, FL 32901, USADepartment of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USATelecraft Engineering Inc., 1254 Mount Carmel Church Lane, Canton, GA 30114, USATelecraft Engineering Inc., 1254 Mount Carmel Church Lane, Canton, GA 30114, USAInfrasonix Inc., 1665 Lakes Parkway, Suite 102, Lawrenceville, GA 30043, USAFor the early detection of atherosclerosis, it is imperative to explore the capabilities of new, effective noninvasive diagnosis techniques to significantly reduce the associated treatment costs and mortality rates. In this study, a multifaceted comprehensive approach involving advanced computational fluid dynamics combined with signal processing techniques was exploited to investigate the highly turbulent fluctuating flow through arterial stenosis. The focus was on localizing high-energy mechano-acoustic source potential to transmit to the epidermal surface. The flow analysis results showed the existence of turbulent pressure fluctuations inside the stenosis and in the post-stenotic region. After analyzing the turbulent kinetic energy and pressure fluctuations on the flow centerline and the vessel wall, the point of maximum excitation in the flow was observed around two diameters downstream of the stenosis within the fluctuating zone. It was also found that the concentration of pressure fluctuation closer to the wall was higher inside the stenosis compared to the post-stenotic region. Additionally, the visualization of the most energetic proper orthogonal decomposition (POD) mode and spectral decomposition of the flow indicated that the break frequencies ranged from 80 to 220 Hz and were correlated to the eddies generated within these regions.https://www.mdpi.com/2306-5354/8/3/34cardiovascular diseasesatherosclerosisstenosisspectral decompositionturbulent pressure fluctuationssound localization |
| spellingShingle | Fardin Khalili Peshala T. Gamage Amirtahà Taebi Mark E. Johnson Randal B. Roberts John Mitchel Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis Bioengineering cardiovascular diseases atherosclerosis stenosis spectral decomposition turbulent pressure fluctuations sound localization |
| title | Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
| title_full | Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
| title_fullStr | Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
| title_full_unstemmed | Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
| title_short | Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
| title_sort | spectral decomposition and sound source localization of highly disturbed flow through a severe arterial stenosis |
| topic | cardiovascular diseases atherosclerosis stenosis spectral decomposition turbulent pressure fluctuations sound localization |
| url | https://www.mdpi.com/2306-5354/8/3/34 |
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