The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy
Diabetic choroidopathy was first described on histopathological specimens of diabetic eyes. This alteration was characterized by the accumulation of PAS-positive material within the intracapillary stroma. Inflammation and polymorphonuclear neutrophils (PMNs) activation are crucial elements in chorio...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/12/10167 |
| _version_ | 1797594299743862784 |
|---|---|
| author | Luca Scuderi Serena Fragiotta Mariachiara Di Pippo Solmaz Abdolrahimzadeh |
| author_facet | Luca Scuderi Serena Fragiotta Mariachiara Di Pippo Solmaz Abdolrahimzadeh |
| author_sort | Luca Scuderi |
| collection | DOAJ |
| description | Diabetic choroidopathy was first described on histopathological specimens of diabetic eyes. This alteration was characterized by the accumulation of PAS-positive material within the intracapillary stroma. Inflammation and polymorphonuclear neutrophils (PMNs) activation are crucial elements in choriocapillaris impairment. The evidence of diabetic choroidopathy in vivo was confirmed with multimodal imaging, which provides key quantitative and qualitative features to characterize the choroidal involvement. The choroid can be virtually affected in each vascular layer, from Haller’s layer to the choriocapillaris. However, the damage on the outer retina and photoreceptor cells is essentially driven by a choriocapillaris deficiency, which can be assessed through optical coherence tomography angiography (OCTA). The identification of characteristic features of diabetic choroidopathy can be significant for understanding the potential pathogenic and prognostic implications in diabetic retinopathy. |
| first_indexed | 2024-03-11T02:21:48Z |
| format | Article |
| id | doaj.art-bfebd60039514849ad85c8b564ac312a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:21:48Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bfebd60039514849ad85c8b564ac312a2023-11-18T10:49:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121016710.3390/ijms241210167The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic RetinopathyLuca Scuderi0Serena Fragiotta1Mariachiara Di Pippo2Solmaz Abdolrahimzadeh3Department of Sense Organs, Sapienza University of Rome, 00161 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Sapienza University of Rome, Via di Grottarossa 1035/1039, 00189 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Sapienza University of Rome, Via di Grottarossa 1035/1039, 00189 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Sapienza University of Rome, Via di Grottarossa 1035/1039, 00189 Rome, ItalyDiabetic choroidopathy was first described on histopathological specimens of diabetic eyes. This alteration was characterized by the accumulation of PAS-positive material within the intracapillary stroma. Inflammation and polymorphonuclear neutrophils (PMNs) activation are crucial elements in choriocapillaris impairment. The evidence of diabetic choroidopathy in vivo was confirmed with multimodal imaging, which provides key quantitative and qualitative features to characterize the choroidal involvement. The choroid can be virtually affected in each vascular layer, from Haller’s layer to the choriocapillaris. However, the damage on the outer retina and photoreceptor cells is essentially driven by a choriocapillaris deficiency, which can be assessed through optical coherence tomography angiography (OCTA). The identification of characteristic features of diabetic choroidopathy can be significant for understanding the potential pathogenic and prognostic implications in diabetic retinopathy.https://www.mdpi.com/1422-0067/24/12/10167diabetic choroidopathydiabetes mellitusdiabetic retinopathychoriocapillarischoroidoptical coherence tomography |
| spellingShingle | Luca Scuderi Serena Fragiotta Mariachiara Di Pippo Solmaz Abdolrahimzadeh The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy International Journal of Molecular Sciences diabetic choroidopathy diabetes mellitus diabetic retinopathy choriocapillaris choroid optical coherence tomography |
| title | The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy |
| title_full | The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy |
| title_fullStr | The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy |
| title_full_unstemmed | The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy |
| title_short | The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy |
| title_sort | role of diabetic choroidopathy in the pathogenesis and progression of diabetic retinopathy |
| topic | diabetic choroidopathy diabetes mellitus diabetic retinopathy choriocapillaris choroid optical coherence tomography |
| url | https://www.mdpi.com/1422-0067/24/12/10167 |
| work_keys_str_mv | AT lucascuderi theroleofdiabeticchoroidopathyinthepathogenesisandprogressionofdiabeticretinopathy AT serenafragiotta theroleofdiabeticchoroidopathyinthepathogenesisandprogressionofdiabeticretinopathy AT mariachiaradipippo theroleofdiabeticchoroidopathyinthepathogenesisandprogressionofdiabeticretinopathy AT solmazabdolrahimzadeh theroleofdiabeticchoroidopathyinthepathogenesisandprogressionofdiabeticretinopathy AT lucascuderi roleofdiabeticchoroidopathyinthepathogenesisandprogressionofdiabeticretinopathy AT serenafragiotta roleofdiabeticchoroidopathyinthepathogenesisandprogressionofdiabeticretinopathy AT mariachiaradipippo roleofdiabeticchoroidopathyinthepathogenesisandprogressionofdiabeticretinopathy AT solmazabdolrahimzadeh roleofdiabeticchoroidopathyinthepathogenesisandprogressionofdiabeticretinopathy |