A single-cysteine mutant and chimeras of essential Leishmania Erv can complement the loss of Erv1 but not of Mia40 in yeast

A single-cysteine mutant and chimeras of essential Leishmania Erv can complement the loss of Erv1 but not of Mia40 in yeast

Mia40/CHCHD4 and Erv1/ALR are essential for oxidative protein folding in the mitochondrial intermembrane space of yeast and mammals. In contrast, many protists, including important apicomplexan and kinetoplastid parasites, lack Mia40. Furthermore, the Erv homolog of the model parasite Leishmania tar...

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Bibliographic Details
Main Authors: Sandra Specht, Linda Liedgens, Margarida Duarte, Alexandra Stiegler, Ulrike Wirth, Maike Eberhardt, Ana Tomás, Kai Hell, Marcel Deponte
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Redox Biology
Subjects:
ALR
CHCHD4
Erv
Intermembrane space
Leishmania
Mia40
Mitochondria
Oxidative protein folding
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717306456

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