The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand
Cholangiocarcinoma (CCA) is the most prevalent malignancy in Thailand, with unfortunate late diagnosis and frequent metastatic disease outcomes. An accurate tissue diagnosis is the first and most important step in the treatment of CCA. Tissue quality and preservation during the pre-analytical phase...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.792847/full |
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| author | Supinda Koonmee Supinda Koonmee Supinda Koonmee Sakkarn Sangkhamanon Sakkarn Sangkhamanon Sakkarn Sangkhamanon Piyapharom Intarawichian Piyapharom Intarawichian Piyapharom Intarawichian Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Waritta Kunprom Waritta Kunprom Waritta Kunprom Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Suwit Balthaisong Suwit Balthaisong Suwit Balthaisong Chitsakul Phuyao Chitsakul Phuyao Chitsakul Phuyao Piya Prajumwongs Piya Prajumwongs Piya Prajumwongs Reza Alaghehbandan Malinee Thanee Malinee Thanee Malinee Thanee |
| author_facet | Supinda Koonmee Supinda Koonmee Supinda Koonmee Sakkarn Sangkhamanon Sakkarn Sangkhamanon Sakkarn Sangkhamanon Piyapharom Intarawichian Piyapharom Intarawichian Piyapharom Intarawichian Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Waritta Kunprom Waritta Kunprom Waritta Kunprom Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Suwit Balthaisong Suwit Balthaisong Suwit Balthaisong Chitsakul Phuyao Chitsakul Phuyao Chitsakul Phuyao Piya Prajumwongs Piya Prajumwongs Piya Prajumwongs Reza Alaghehbandan Malinee Thanee Malinee Thanee Malinee Thanee |
| author_sort | Supinda Koonmee |
| collection | DOAJ |
| description | Cholangiocarcinoma (CCA) is the most prevalent malignancy in Thailand, with unfortunate late diagnosis and frequent metastatic disease outcomes. An accurate tissue diagnosis is the first and most important step in the treatment of CCA. Tissue quality and preservation during the pre-analytical phase play major roles in the proper histological evaluation and potential biomarker testing. This study evaluated the impact of using the “Cholangiocarcinoma Screening and Care Program (CASCAP)” container, as an innovative tool to address pre-analytical challenges faced by pathology laboratories in Thailand. This is a comparison study examining the quality of CCA specimens using the CASCAP container vs. the conventional method, using hematoxylin and eosin (H&E) and immunohistochemistry (IHC). CCA tissue quality using the CASCAP container significantly reduced artifact deposition while improving the cellular structure and nuclear and cytoplasmic morphologies. The immunohistochemical expression of cytokeratin 19 (CK19), a prognostic marker in CCA, significantly improved in the CASCAP container group in comparison with the conventional method. This innovation is proven to significantly enhance the CCA tissue quality diagnostics and prognostic biomarker testing, hence improving overall cancer care, diagnosis, and treatment in Thailand. |
| first_indexed | 2024-12-12T10:30:19Z |
| format | Article |
| id | doaj.art-bfee696904434c7b85385da385b3d9f7 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-12T10:30:19Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-bfee696904434c7b85385da385b3d9f72022-12-22T00:27:23ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-06-011010.3389/fpubh.2022.792847792847The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in ThailandSupinda Koonmee0Supinda Koonmee1Supinda Koonmee2Sakkarn Sangkhamanon3Sakkarn Sangkhamanon4Sakkarn Sangkhamanon5Piyapharom Intarawichian6Piyapharom Intarawichian7Piyapharom Intarawichian8Chaiwat Aphivatanasiri9Chaiwat Aphivatanasiri10Chaiwat Aphivatanasiri11Waritta Kunprom12Waritta Kunprom13Waritta Kunprom14Prakasit Sa-ngiamwibool15Prakasit Sa-ngiamwibool16Prakasit Sa-ngiamwibool17Suwit Balthaisong18Suwit Balthaisong19Suwit Balthaisong20Chitsakul Phuyao21Chitsakul Phuyao22Chitsakul Phuyao23Piya Prajumwongs24Piya Prajumwongs25Piya Prajumwongs26Reza Alaghehbandan27Malinee Thanee28Malinee Thanee29Malinee Thanee30Cholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Royal Columbian Hospital, University of British Columbia, Vancouver, BC, CanadaCholangiocarcinoma Screening and Care Program, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma (CCA) is the most prevalent malignancy in Thailand, with unfortunate late diagnosis and frequent metastatic disease outcomes. An accurate tissue diagnosis is the first and most important step in the treatment of CCA. Tissue quality and preservation during the pre-analytical phase play major roles in the proper histological evaluation and potential biomarker testing. This study evaluated the impact of using the “Cholangiocarcinoma Screening and Care Program (CASCAP)” container, as an innovative tool to address pre-analytical challenges faced by pathology laboratories in Thailand. This is a comparison study examining the quality of CCA specimens using the CASCAP container vs. the conventional method, using hematoxylin and eosin (H&E) and immunohistochemistry (IHC). CCA tissue quality using the CASCAP container significantly reduced artifact deposition while improving the cellular structure and nuclear and cytoplasmic morphologies. The immunohistochemical expression of cytokeratin 19 (CK19), a prognostic marker in CCA, significantly improved in the CASCAP container group in comparison with the conventional method. This innovation is proven to significantly enhance the CCA tissue quality diagnostics and prognostic biomarker testing, hence improving overall cancer care, diagnosis, and treatment in Thailand.https://www.frontiersin.org/articles/10.3389/fpubh.2022.792847/fullcholangiocarcinomapre-analytical phasetissue preservationimmunohistochemistryhistopathology |
| spellingShingle | Supinda Koonmee Supinda Koonmee Supinda Koonmee Sakkarn Sangkhamanon Sakkarn Sangkhamanon Sakkarn Sangkhamanon Piyapharom Intarawichian Piyapharom Intarawichian Piyapharom Intarawichian Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Chaiwat Aphivatanasiri Waritta Kunprom Waritta Kunprom Waritta Kunprom Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Prakasit Sa-ngiamwibool Suwit Balthaisong Suwit Balthaisong Suwit Balthaisong Chitsakul Phuyao Chitsakul Phuyao Chitsakul Phuyao Piya Prajumwongs Piya Prajumwongs Piya Prajumwongs Reza Alaghehbandan Malinee Thanee Malinee Thanee Malinee Thanee The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand Frontiers in Public Health cholangiocarcinoma pre-analytical phase tissue preservation immunohistochemistry histopathology |
| title | The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand |
| title_full | The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand |
| title_fullStr | The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand |
| title_full_unstemmed | The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand |
| title_short | The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand |
| title_sort | impact of pre analytical quality initiatives on cholangiocarcinoma diagnostics in thailand |
| topic | cholangiocarcinoma pre-analytical phase tissue preservation immunohistochemistry histopathology |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.792847/full |
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