Andrographis Paniculata (Burm. F.) Nees Induces Clinical and Sputum Conversion in Pulmonary Tuberculosis Patients
The aim of this study was to determine whether Andrographus paniculata capsule induces clinical and sputum conversion in pulmonary tuberculosis (TB) patients. Randomized, placebo-controlled, double-blind pi¬lot study was conducted to pulmonary tuberculosis patient who admitted to Pulmonology Polycli...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2015-03-01
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| Series: | Medicine Science |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=163784 |
| _version_ | 1797328547135619072 |
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| author | Riswahyuni Widhawati Endang Hanani Jamal Zaini |
| author_facet | Riswahyuni Widhawati Endang Hanani Jamal Zaini |
| author_sort | Riswahyuni Widhawati |
| collection | DOAJ |
| description | The aim of this study was to determine whether Andrographus paniculata capsule induces clinical and sputum conversion in pulmonary tuberculosis (TB) patients. Randomized, placebo-controlled, double-blind pi¬lot study was conducted to pulmonary tuberculosis patient who admitted to Pulmonology Polyclinic of Persahabatan Central General Hospital, Jakarta. A total of 44 pulmonary TB patients were randomly divided into two groups including one group received standard antituberculosis drugs + Andrographis paniculata (n=21) (AP) and one group received standard antituberculosis drugs + placebo (n=23). APC was given 500 milligram per day for eight weeks. The distribution of sex, body weight and body mass index (BMI) as well as the frequency of cough and feature of chest radiography were not significantly different between groups (P >0.05). The proportion of posi¬tive smears in both groups decreased over time until by the twelve weeks, none remained positive. The rate of decline was more pronounced in the AP group reach statistically at weeks 4 and 6 compared to placebo group (P < 0.05). Adjunc¬tive supplementation of Andrographis paniculata (Burm. F.) Nees was to accelerated the beneficial therapeutic effect of TB chemotherapy by improving clinical and sputum response. [Med-Science 2015; 4(1.000): 1869-75] |
| first_indexed | 2024-03-08T06:53:20Z |
| format | Article |
| id | doaj.art-bfef472b3a1a4dde94a9b53532c0febc |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:53:20Z |
| publishDate | 2015-03-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-bfef472b3a1a4dde94a9b53532c0febc2024-02-03T06:40:27ZengSociety of Turaz BilimMedicine Science2147-06342015-03-014118697510.5455/medscience.2014.03.8184163784Andrographis Paniculata (Burm. F.) Nees Induces Clinical and Sputum Conversion in Pulmonary Tuberculosis PatientsRiswahyuni Widhawati0Endang Hanani1Jamal Zaini2Post-Graduate Programme of Herbal Medicine, Faculty of Pharmacy, University of Indonesia, Depok 16424, Indonesia Faculty of Pharmacy, University of Indonesia, Depok 16424, Indonesia Department of Pulmonology and Respiratory Medicine, Faculty of Medicine University of Indonesia - Persahabatan General Hospital, Jakarta, IndonesiaThe aim of this study was to determine whether Andrographus paniculata capsule induces clinical and sputum conversion in pulmonary tuberculosis (TB) patients. Randomized, placebo-controlled, double-blind pi¬lot study was conducted to pulmonary tuberculosis patient who admitted to Pulmonology Polyclinic of Persahabatan Central General Hospital, Jakarta. A total of 44 pulmonary TB patients were randomly divided into two groups including one group received standard antituberculosis drugs + Andrographis paniculata (n=21) (AP) and one group received standard antituberculosis drugs + placebo (n=23). APC was given 500 milligram per day for eight weeks. The distribution of sex, body weight and body mass index (BMI) as well as the frequency of cough and feature of chest radiography were not significantly different between groups (P >0.05). The proportion of posi¬tive smears in both groups decreased over time until by the twelve weeks, none remained positive. The rate of decline was more pronounced in the AP group reach statistically at weeks 4 and 6 compared to placebo group (P < 0.05). Adjunc¬tive supplementation of Andrographis paniculata (Burm. F.) Nees was to accelerated the beneficial therapeutic effect of TB chemotherapy by improving clinical and sputum response. [Med-Science 2015; 4(1.000): 1869-75]http://www.ejmanager.com/fulltextpdf.php?mno=163784Antimicrobialandrographis paniculatasputum conversiontuberculosis |
| spellingShingle | Riswahyuni Widhawati Endang Hanani Jamal Zaini Andrographis Paniculata (Burm. F.) Nees Induces Clinical and Sputum Conversion in Pulmonary Tuberculosis Patients Medicine Science Antimicrobial andrographis paniculata sputum conversion tuberculosis |
| title | Andrographis Paniculata (Burm. F.) Nees Induces Clinical and Sputum Conversion in Pulmonary Tuberculosis Patients |
| title_full | Andrographis Paniculata (Burm. F.) Nees Induces Clinical and Sputum Conversion in Pulmonary Tuberculosis Patients |
| title_fullStr | Andrographis Paniculata (Burm. F.) Nees Induces Clinical and Sputum Conversion in Pulmonary Tuberculosis Patients |
| title_full_unstemmed | Andrographis Paniculata (Burm. F.) Nees Induces Clinical and Sputum Conversion in Pulmonary Tuberculosis Patients |
| title_short | Andrographis Paniculata (Burm. F.) Nees Induces Clinical and Sputum Conversion in Pulmonary Tuberculosis Patients |
| title_sort | andrographis paniculata burm f nees induces clinical and sputum conversion in pulmonary tuberculosis patients |
| topic | Antimicrobial andrographis paniculata sputum conversion tuberculosis |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=163784 |
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