Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease
Reduced cerebrovascular compliance is the major mechanism of cerebral small vessel disease (SVD). Obstructive sleep apnea (OSA) also promotes SVD development, but the underlying mechanism was not elucidated. We investigated the association among OSA, cerebrovascular compliance, and SVD parameters. T...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589195/?tool=EBI |
| _version_ | 1818836148250738688 |
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| author | Woo-Jin Lee Keun-Hwa Jung Hyun-Woo Nam Yong-Seok Lee |
| author_facet | Woo-Jin Lee Keun-Hwa Jung Hyun-Woo Nam Yong-Seok Lee |
| author_sort | Woo-Jin Lee |
| collection | DOAJ |
| description | Reduced cerebrovascular compliance is the major mechanism of cerebral small vessel disease (SVD). Obstructive sleep apnea (OSA) also promotes SVD development, but the underlying mechanism was not elucidated. We investigated the association among OSA, cerebrovascular compliance, and SVD parameters. This study retrospectively included individuals ≥ 50 years of age, underwent overnight polysomnographic (PSG) for the evaluation of OSA, and performed MRI and transcranial Doppler (TCD) within 12 months of interval without a neurological event between the evaluations. TCD parameters for the cerebrovascular compliance included middle cerebral artery pulsatility index (MCA PI) and mean MCA resistance index ratio (MRIR). SVD parameters included white matter hyperintensity (WMH) volume, number of lacunes, enlarged perivascular space (ePVS) score, and the presence of microbleeds or lacunes. Ninety-seven individuals (60.8% male, mean age 70.0±10.5 years) were included. MRIR was associated with higher respiratory distress index (B = 0.003; 95% confidence interval [CI] 0.001–0.005; P = 0.021), while MCA PI was not associated with any of the PSG markers for OSA severity. Apnea-hypopnea index was associated with the log-transformed total WMH volume (B = 0.008; 95% confidence interval [CI] 0.001–0.016; P = 0.020), subcortical WMH volume (B = 0.015; 95% CI 0.007–0.022; P<0.001), total ePVS score (B = 0.024; 95% CI 0.003–0.045; P = 0.026), and centrum semiovale ePVS score (B = 0.026; 95% CI 0.004–0.048; P = 0.019), and oxygen-desaturation index with periventricular WMH volume, independently from age, MCA PI, and MRIR. This study concluded that OSA is associated with reduced cerebrovascular compliance and also with SVD independently from cerebrovascular compliance. Underlying pathomechanistic link might be region specific. |
| first_indexed | 2024-12-19T03:02:00Z |
| format | Article |
| id | doaj.art-bff1b3102cc14484b03781703c4aec3b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T03:02:00Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-bff1b3102cc14484b03781703c4aec3b2022-12-21T20:38:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011611Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel diseaseWoo-Jin LeeKeun-Hwa JungHyun-Woo NamYong-Seok LeeReduced cerebrovascular compliance is the major mechanism of cerebral small vessel disease (SVD). Obstructive sleep apnea (OSA) also promotes SVD development, but the underlying mechanism was not elucidated. We investigated the association among OSA, cerebrovascular compliance, and SVD parameters. This study retrospectively included individuals ≥ 50 years of age, underwent overnight polysomnographic (PSG) for the evaluation of OSA, and performed MRI and transcranial Doppler (TCD) within 12 months of interval without a neurological event between the evaluations. TCD parameters for the cerebrovascular compliance included middle cerebral artery pulsatility index (MCA PI) and mean MCA resistance index ratio (MRIR). SVD parameters included white matter hyperintensity (WMH) volume, number of lacunes, enlarged perivascular space (ePVS) score, and the presence of microbleeds or lacunes. Ninety-seven individuals (60.8% male, mean age 70.0±10.5 years) were included. MRIR was associated with higher respiratory distress index (B = 0.003; 95% confidence interval [CI] 0.001–0.005; P = 0.021), while MCA PI was not associated with any of the PSG markers for OSA severity. Apnea-hypopnea index was associated with the log-transformed total WMH volume (B = 0.008; 95% confidence interval [CI] 0.001–0.016; P = 0.020), subcortical WMH volume (B = 0.015; 95% CI 0.007–0.022; P<0.001), total ePVS score (B = 0.024; 95% CI 0.003–0.045; P = 0.026), and centrum semiovale ePVS score (B = 0.026; 95% CI 0.004–0.048; P = 0.019), and oxygen-desaturation index with periventricular WMH volume, independently from age, MCA PI, and MRIR. This study concluded that OSA is associated with reduced cerebrovascular compliance and also with SVD independently from cerebrovascular compliance. Underlying pathomechanistic link might be region specific.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589195/?tool=EBI |
| spellingShingle | Woo-Jin Lee Keun-Hwa Jung Hyun-Woo Nam Yong-Seok Lee Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease PLoS ONE |
| title | Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease |
| title_full | Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease |
| title_fullStr | Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease |
| title_full_unstemmed | Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease |
| title_short | Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease |
| title_sort | effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589195/?tool=EBI |
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