Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications
Meibomian gland, the largest sebaceous gland of the body, is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive evaporation. The loss of normal functions of meibomian gland, known as meibomian gland dysfunction (MGD), is a chronic disease and is the leading cause o...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2021-06-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2021/6/20210618.pdf |
| _version_ | 1828918941077995520 |
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| author | Li-Xiang Wang Ying-Ping Deng |
| author_facet | Li-Xiang Wang Ying-Ping Deng |
| author_sort | Li-Xiang Wang |
| collection | DOAJ |
| description | Meibomian gland, the largest sebaceous gland of the body, is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive evaporation. The loss of normal functions of meibomian gland, known as meibomian gland dysfunction (MGD), is a chronic disease and is the leading cause of dry eye symptoms in the clinics. Studies have found sex hormones, especially androgen, play vital roles in the regulation of the functions of meibomian gland. Recently, androgen has also been preliminarily applied in clinics for the treatment of MGD and showed promising results, especially in people with endogenous androgen deficiency. This review summarized the mechanisms of the function of androgen on meibomian gland based on molecular, animal, and clinical studies, and proposed evidence-based views about its potential applications for the treatment of MGD. |
| first_indexed | 2024-12-13T21:19:14Z |
| format | Article |
| id | doaj.art-bff1cf037def43c2939e9f39aef59b72 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-13T21:19:14Z |
| publishDate | 2021-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-bff1cf037def43c2939e9f39aef59b722022-12-21T23:31:10ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982021-06-0114691592210.18240/ijo.2021.06.1820210618Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applicationsLi-Xiang Wang0Ying-Ping Deng1Ying-Ping Deng. Department of Ophthalmology, West China Hospital of Sichuan University, No.37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. ypd_wch@163.comDepartment of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, ChinaMeibomian gland, the largest sebaceous gland of the body, is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive evaporation. The loss of normal functions of meibomian gland, known as meibomian gland dysfunction (MGD), is a chronic disease and is the leading cause of dry eye symptoms in the clinics. Studies have found sex hormones, especially androgen, play vital roles in the regulation of the functions of meibomian gland. Recently, androgen has also been preliminarily applied in clinics for the treatment of MGD and showed promising results, especially in people with endogenous androgen deficiency. This review summarized the mechanisms of the function of androgen on meibomian gland based on molecular, animal, and clinical studies, and proposed evidence-based views about its potential applications for the treatment of MGD.http://ies.ijo.cn/en_publish/2021/6/20210618.pdfmeibomian gland dysfunctionandrogendry eye disease |
| spellingShingle | Li-Xiang Wang Ying-Ping Deng Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications International Journal of Ophthalmology meibomian gland dysfunction androgen dry eye disease |
| title | Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications |
| title_full | Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications |
| title_fullStr | Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications |
| title_full_unstemmed | Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications |
| title_short | Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications |
| title_sort | androgen and meibomian gland dysfunction from basic molecular biology to clinical applications |
| topic | meibomian gland dysfunction androgen dry eye disease |
| url | http://ies.ijo.cn/en_publish/2021/6/20210618.pdf |
| work_keys_str_mv | AT lixiangwang androgenandmeibomianglanddysfunctionfrombasicmolecularbiologytoclinicalapplications AT yingpingdeng androgenandmeibomianglanddysfunctionfrombasicmolecularbiologytoclinicalapplications |