A cross-sectional study on factors associated with hypertension and genetic polymorphisms of renin-angiotensin-aldosterone system in Chinese hui pilgrims to hajj
Abstract Background Hypertension is the leading risk factor for cardiovascular disease (CVD), however, the studies on lifestyle and genetic risks in Chinese pilgrims to Hajj was limited. The aim of this study is to examine the prevalence and associated lifestyle and genetic risks for hypertension am...
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12889-019-7357-1 |
| _version_ | 1819265804307267584 |
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| author | Yinxia Zhang Fangfang Shi Zhanbiao Yu Aimin Yang Maolan Zeng Jiaoyue Wang Haiping Yin Benzhong Zhang Xiao Ma |
| author_facet | Yinxia Zhang Fangfang Shi Zhanbiao Yu Aimin Yang Maolan Zeng Jiaoyue Wang Haiping Yin Benzhong Zhang Xiao Ma |
| author_sort | Yinxia Zhang |
| collection | DOAJ |
| description | Abstract Background Hypertension is the leading risk factor for cardiovascular disease (CVD), however, the studies on lifestyle and genetic risks in Chinese pilgrims to Hajj was limited. The aim of this study is to examine the prevalence and associated lifestyle and genetic risks for hypertension among Hui Hajj pilgrims in China. Methods We performed a cross-sectional analysis of data in 1,465 participants aged 30–70 years who participated in a medical examination for Hui Hajj pilgrims from Gansu province, China in 2017. Multiple logistic regression was used to evaluate the association of potential risk factors with hypertension. Deoxyribonucleic acid (DNA) polymorphism was examined at sites in the renin-angiotensin-aldosterone system (RAAS). Results The prevalence of hypertension was 47% among this population. Lifestyle factors such as fried food preference (like vs. dislike: odds ratio [OR]: =1.53, 95% confidence interval [CI]: 1.13–2.09) and barbecued food preference (like vs. dislike: OR = 1.45, 95% CI: 1.06–1.97) were associated with elevated risk of hypertension among Hui pilgrims. Comparing with Angiotensin converting enzyme (ACE) rs4425 AA genotype, TT genotype was associated with hypertension risk (OR = 2.16, 95% CI: 1.17–4.00). Similar results were also observed for ACE rs4437 CC genotype (OR = 1.95, 95% CI: 1.07–3.55), Angiotensin II receptor (ATR) rs129876 AA genotype (OR = 4.10, 95% CI: 2.30–7.32) and Aldosterone synthase (CYP11B2) rs1912 TT genotype (OR = 2.82, 95% CI: 1.57–5.06) genotypes. Conclusions Unhealthy lifestyle and genetic factors were associated with the prevalence of hypertension in Chinese Hui pilgrims and their interactions were also observed. |
| first_indexed | 2024-12-23T20:51:12Z |
| format | Article |
| id | doaj.art-bff21bd434834854939d889346364ea2 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-23T20:51:12Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-bff21bd434834854939d889346364ea22022-12-21T17:31:39ZengBMCBMC Public Health1471-24582019-09-0119111110.1186/s12889-019-7357-1A cross-sectional study on factors associated with hypertension and genetic polymorphisms of renin-angiotensin-aldosterone system in Chinese hui pilgrims to hajjYinxia Zhang0Fangfang Shi1Zhanbiao Yu2Aimin Yang3Maolan Zeng4Jiaoyue Wang5Haiping Yin6Benzhong Zhang7Xiao Ma8West China School of Public Health and West China Fourth Hospital, Sichuan UniversityCenter for Disease Control and PreventionQingyang People’s HospitalHong Kong Institute of Diabetes and Obesity, The Chinese University of Hong KongNorthwest Minzu UniversityGansu International Travel Healthcare CenterGansu International Travel Healthcare CenterSchool of Public Health, Lanzhou UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityAbstract Background Hypertension is the leading risk factor for cardiovascular disease (CVD), however, the studies on lifestyle and genetic risks in Chinese pilgrims to Hajj was limited. The aim of this study is to examine the prevalence and associated lifestyle and genetic risks for hypertension among Hui Hajj pilgrims in China. Methods We performed a cross-sectional analysis of data in 1,465 participants aged 30–70 years who participated in a medical examination for Hui Hajj pilgrims from Gansu province, China in 2017. Multiple logistic regression was used to evaluate the association of potential risk factors with hypertension. Deoxyribonucleic acid (DNA) polymorphism was examined at sites in the renin-angiotensin-aldosterone system (RAAS). Results The prevalence of hypertension was 47% among this population. Lifestyle factors such as fried food preference (like vs. dislike: odds ratio [OR]: =1.53, 95% confidence interval [CI]: 1.13–2.09) and barbecued food preference (like vs. dislike: OR = 1.45, 95% CI: 1.06–1.97) were associated with elevated risk of hypertension among Hui pilgrims. Comparing with Angiotensin converting enzyme (ACE) rs4425 AA genotype, TT genotype was associated with hypertension risk (OR = 2.16, 95% CI: 1.17–4.00). Similar results were also observed for ACE rs4437 CC genotype (OR = 1.95, 95% CI: 1.07–3.55), Angiotensin II receptor (ATR) rs129876 AA genotype (OR = 4.10, 95% CI: 2.30–7.32) and Aldosterone synthase (CYP11B2) rs1912 TT genotype (OR = 2.82, 95% CI: 1.57–5.06) genotypes. Conclusions Unhealthy lifestyle and genetic factors were associated with the prevalence of hypertension in Chinese Hui pilgrims and their interactions were also observed.http://link.springer.com/article/10.1186/s12889-019-7357-1PilgrimsHypertensionRAASPolymorphism |
| spellingShingle | Yinxia Zhang Fangfang Shi Zhanbiao Yu Aimin Yang Maolan Zeng Jiaoyue Wang Haiping Yin Benzhong Zhang Xiao Ma A cross-sectional study on factors associated with hypertension and genetic polymorphisms of renin-angiotensin-aldosterone system in Chinese hui pilgrims to hajj BMC Public Health Pilgrims Hypertension RAAS Polymorphism |
| title | A cross-sectional study on factors associated with hypertension and genetic polymorphisms of renin-angiotensin-aldosterone system in Chinese hui pilgrims to hajj |
| title_full | A cross-sectional study on factors associated with hypertension and genetic polymorphisms of renin-angiotensin-aldosterone system in Chinese hui pilgrims to hajj |
| title_fullStr | A cross-sectional study on factors associated with hypertension and genetic polymorphisms of renin-angiotensin-aldosterone system in Chinese hui pilgrims to hajj |
| title_full_unstemmed | A cross-sectional study on factors associated with hypertension and genetic polymorphisms of renin-angiotensin-aldosterone system in Chinese hui pilgrims to hajj |
| title_short | A cross-sectional study on factors associated with hypertension and genetic polymorphisms of renin-angiotensin-aldosterone system in Chinese hui pilgrims to hajj |
| title_sort | cross sectional study on factors associated with hypertension and genetic polymorphisms of renin angiotensin aldosterone system in chinese hui pilgrims to hajj |
| topic | Pilgrims Hypertension RAAS Polymorphism |
| url | http://link.springer.com/article/10.1186/s12889-019-7357-1 |
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