Folate Biofortification in Soybean: Challenges and Prospects
Folate deficiency is a significant global health issue that affects millions of people and causes severe adverse effects. Major staple crops, which provide significant amounts of calories, often contain inadequate folate levels. Synthetic fortification has contributed to a reduction in low-folate po...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Agronomy |
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| Online Access: | https://www.mdpi.com/2073-4395/13/1/241 |
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| author | Kwadwo Gyapong Agyenim-Boateng Shengrui Zhang Md. Jahidul Islam Shohag Abdulwahab S. Shaibu Jing Li Bin Li Junming Sun |
| author_facet | Kwadwo Gyapong Agyenim-Boateng Shengrui Zhang Md. Jahidul Islam Shohag Abdulwahab S. Shaibu Jing Li Bin Li Junming Sun |
| author_sort | Kwadwo Gyapong Agyenim-Boateng |
| collection | DOAJ |
| description | Folate deficiency is a significant global health issue that affects millions of people and causes severe adverse effects. Major staple crops, which provide significant amounts of calories, often contain inadequate folate levels. Synthetic fortification has contributed to a reduction in low-folate populations, but a more sustainable solution is needed. Biofortification, or the breeding of crops to naturally increase their nutrient content, is a promising alternative. Soybean is a highly nutritious crop and a good candidate for folate biofortification. However, studies on folate have been limited due to the challenges in folate analysis. The development of sensitive and selective tools, reference materials, and studies on the stability of folate vitamers in crops has facilitated the development of improved folate determination methods. Additionally, the soybean folate biofortification program can be improved by leveraging previous studies in major cereals, common bean and pea, as well as combining conventional breeding with new genomics approaches. In this review, we discuss the folate content, composition, and analytical challenges in soybean and suggest possible frameworks and strategies for folate biofortification in soybean. We also conducted an in silico analysis of key folate biosynthesis enzymes in soybean. |
| first_indexed | 2024-03-09T13:50:27Z |
| format | Article |
| id | doaj.art-bff33c0a940b476ea59816ed541e2524 |
| institution | Directory Open Access Journal |
| issn | 2073-4395 |
| language | English |
| last_indexed | 2024-03-09T13:50:27Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Agronomy |
| spelling | doaj.art-bff33c0a940b476ea59816ed541e25242023-11-30T20:51:01ZengMDPI AGAgronomy2073-43952023-01-0113124110.3390/agronomy13010241Folate Biofortification in Soybean: Challenges and ProspectsKwadwo Gyapong Agyenim-Boateng0Shengrui Zhang1Md. Jahidul Islam Shohag2Abdulwahab S. Shaibu3Jing Li4Bin Li5Junming Sun6The National Engineering Laboratory for Crop Molecular Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaThe National Engineering Laboratory for Crop Molecular Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaDepartment of Agriculture, Faculty of Agricultural Sciences, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, BangladeshThe National Engineering Laboratory for Crop Molecular Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaThe National Engineering Laboratory for Crop Molecular Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaThe National Engineering Laboratory for Crop Molecular Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaThe National Engineering Laboratory for Crop Molecular Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaFolate deficiency is a significant global health issue that affects millions of people and causes severe adverse effects. Major staple crops, which provide significant amounts of calories, often contain inadequate folate levels. Synthetic fortification has contributed to a reduction in low-folate populations, but a more sustainable solution is needed. Biofortification, or the breeding of crops to naturally increase their nutrient content, is a promising alternative. Soybean is a highly nutritious crop and a good candidate for folate biofortification. However, studies on folate have been limited due to the challenges in folate analysis. The development of sensitive and selective tools, reference materials, and studies on the stability of folate vitamers in crops has facilitated the development of improved folate determination methods. Additionally, the soybean folate biofortification program can be improved by leveraging previous studies in major cereals, common bean and pea, as well as combining conventional breeding with new genomics approaches. In this review, we discuss the folate content, composition, and analytical challenges in soybean and suggest possible frameworks and strategies for folate biofortification in soybean. We also conducted an in silico analysis of key folate biosynthesis enzymes in soybean.https://www.mdpi.com/2073-4395/13/1/241soybean (<i>Glycine max</i> L. Merrill)folateextractionbiofortificationbreeding |
| spellingShingle | Kwadwo Gyapong Agyenim-Boateng Shengrui Zhang Md. Jahidul Islam Shohag Abdulwahab S. Shaibu Jing Li Bin Li Junming Sun Folate Biofortification in Soybean: Challenges and Prospects Agronomy soybean (<i>Glycine max</i> L. Merrill) folate extraction biofortification breeding |
| title | Folate Biofortification in Soybean: Challenges and Prospects |
| title_full | Folate Biofortification in Soybean: Challenges and Prospects |
| title_fullStr | Folate Biofortification in Soybean: Challenges and Prospects |
| title_full_unstemmed | Folate Biofortification in Soybean: Challenges and Prospects |
| title_short | Folate Biofortification in Soybean: Challenges and Prospects |
| title_sort | folate biofortification in soybean challenges and prospects |
| topic | soybean (<i>Glycine max</i> L. Merrill) folate extraction biofortification breeding |
| url | https://www.mdpi.com/2073-4395/13/1/241 |
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