Iodine status among subclinical and overt hypothyroid patients by urinary iodine assay: A case–control study
Objectives: The objective of the study was to assess the differences of iodine status as measured by urinary iodine excretion (UIE) between cases of hypothyroidism and healthy controls. Materials and Methods: The study was conducted in cases with subclinical hypothyroidism (n = 58) and overt hypothy...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
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| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2017;volume=21;issue=5;spage=719;epage=723;aulast=Shrestha |
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| author | Uma Shrestha Narayan Gautam Krishna Kumar Agrawal Amit Chandra Jha Archana Jayan |
| author_facet | Uma Shrestha Narayan Gautam Krishna Kumar Agrawal Amit Chandra Jha Archana Jayan |
| author_sort | Uma Shrestha |
| collection | DOAJ |
| description | Objectives: The objective of the study was to assess the differences of iodine status as measured by urinary iodine excretion (UIE) between cases of hypothyroidism and healthy controls. Materials and Methods: The study was conducted in cases with subclinical hypothyroidism (n = 58) and overt hypothyroidism (n = 41) and compared with age- and sex-matched healthy euthyroid controls (n = 52) attending Universal College of Medical Sciences Teaching Hospital, Bhairahawa, Nepal. Serum free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) were estimated by competitive ELISA and sandwich ELISA, respectively (Diametra, Italy). The urinary iodine concentration (UIC) in urine samples was estimated by ammonium persulfate digestion method recommended by the WHO. Results: A significantly higher median UIC was observed among cases of subclinical hypothyroidism (224.90 μg/l) and overt hypothyroidism (281.0 μg/l) as compared to the controls (189.90 μg/l) (P = 0.0001, P = 0.001). Serum TSH in the cases of subclinical hypothyroid was higher, whereas fT3 was lower as compared to controls (P = 0.028, P = 0.0001), respectively. Similarly, serum TSH in the cases of overt hypothyroid was higher and fT3 and fT4 were lower as compared to controls (P = 0.0001, P = 0.0001, P = 0.015), respectively. There was positive correlation of UIC with TSH (r = 0.269, P = 0.0001), whereas negative correlation was seen with fT3 (r = −0.328, P = 0.0001) and fT4 (r = −0.145, P = 0.076). The test of multiple regression has shown that fT3(β = −0.262, P = 0.012) as an independent predictor in association with UIE in cases. Conclusion: Excessive iodine intake was found in hypothyroid patients as assessed by UIE concluding that it may trigger the thyroid hypofunction. Cohort studies to generate further evidence should be done to explore potential mechanism of hypothyroidism in excess iodine intake. |
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| format | Article |
| id | doaj.art-bff58d48cd65494294d94e1f9fa25fe9 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-12-14T17:55:10Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-bff58d48cd65494294d94e1f9fa25fe92022-12-21T22:52:34ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102017-01-0121571972310.4103/ijem.IJEM_413_16Iodine status among subclinical and overt hypothyroid patients by urinary iodine assay: A case–control studyUma ShresthaNarayan GautamKrishna Kumar AgrawalAmit Chandra JhaArchana JayanObjectives: The objective of the study was to assess the differences of iodine status as measured by urinary iodine excretion (UIE) between cases of hypothyroidism and healthy controls. Materials and Methods: The study was conducted in cases with subclinical hypothyroidism (n = 58) and overt hypothyroidism (n = 41) and compared with age- and sex-matched healthy euthyroid controls (n = 52) attending Universal College of Medical Sciences Teaching Hospital, Bhairahawa, Nepal. Serum free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) were estimated by competitive ELISA and sandwich ELISA, respectively (Diametra, Italy). The urinary iodine concentration (UIC) in urine samples was estimated by ammonium persulfate digestion method recommended by the WHO. Results: A significantly higher median UIC was observed among cases of subclinical hypothyroidism (224.90 μg/l) and overt hypothyroidism (281.0 μg/l) as compared to the controls (189.90 μg/l) (P = 0.0001, P = 0.001). Serum TSH in the cases of subclinical hypothyroid was higher, whereas fT3 was lower as compared to controls (P = 0.028, P = 0.0001), respectively. Similarly, serum TSH in the cases of overt hypothyroid was higher and fT3 and fT4 were lower as compared to controls (P = 0.0001, P = 0.0001, P = 0.015), respectively. There was positive correlation of UIC with TSH (r = 0.269, P = 0.0001), whereas negative correlation was seen with fT3 (r = −0.328, P = 0.0001) and fT4 (r = −0.145, P = 0.076). The test of multiple regression has shown that fT3(β = −0.262, P = 0.012) as an independent predictor in association with UIE in cases. Conclusion: Excessive iodine intake was found in hypothyroid patients as assessed by UIE concluding that it may trigger the thyroid hypofunction. Cohort studies to generate further evidence should be done to explore potential mechanism of hypothyroidism in excess iodine intake.http://www.ijem.in/article.asp?issn=2230-8210;year=2017;volume=21;issue=5;spage=719;epage=723;aulast=ShresthaExcess iodine intakehypothyroidismiodine statusmedian urinary iodineurinary iodine excretion |
| spellingShingle | Uma Shrestha Narayan Gautam Krishna Kumar Agrawal Amit Chandra Jha Archana Jayan Iodine status among subclinical and overt hypothyroid patients by urinary iodine assay: A case–control study Indian Journal of Endocrinology and Metabolism Excess iodine intake hypothyroidism iodine status median urinary iodine urinary iodine excretion |
| title | Iodine status among subclinical and overt hypothyroid patients by urinary iodine assay: A case–control study |
| title_full | Iodine status among subclinical and overt hypothyroid patients by urinary iodine assay: A case–control study |
| title_fullStr | Iodine status among subclinical and overt hypothyroid patients by urinary iodine assay: A case–control study |
| title_full_unstemmed | Iodine status among subclinical and overt hypothyroid patients by urinary iodine assay: A case–control study |
| title_short | Iodine status among subclinical and overt hypothyroid patients by urinary iodine assay: A case–control study |
| title_sort | iodine status among subclinical and overt hypothyroid patients by urinary iodine assay a case control study |
| topic | Excess iodine intake hypothyroidism iodine status median urinary iodine urinary iodine excretion |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2017;volume=21;issue=5;spage=719;epage=723;aulast=Shrestha |
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