Cancer-Associated Fibroblasts: Implications for Cancer Therapy
Tumour cells do not exist as an isolated entity. Instead, they are surrounded by and closely interact with cells of the environment they are emerged in. The tumour microenvironment (TME) is not static and several factors, including cancer cells and therapies, have been described to modulate several...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/14/3526 |
| _version_ | 1797527483929591808 |
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| author | Ana Maia Stefan Wiemann |
| author_facet | Ana Maia Stefan Wiemann |
| author_sort | Ana Maia |
| collection | DOAJ |
| description | Tumour cells do not exist as an isolated entity. Instead, they are surrounded by and closely interact with cells of the environment they are emerged in. The tumour microenvironment (TME) is not static and several factors, including cancer cells and therapies, have been described to modulate several of its components. Fibroblasts are key elements of the TME with the capacity to influence tumour progression, invasion and response to therapy, which makes them attractive targets in cancer treatment. In this review, we focus on fibroblasts and their numerous roles in the TME with a special attention to recent findings describing their heterogeneity and role in therapy response. Furthermore, we explore how different therapies can impact these cells and their communication with cancer cells. Finally, we highlight potential strategies targeting this cell type that can be employed for improving patient outcome. |
| first_indexed | 2024-03-10T09:44:22Z |
| format | Article |
| id | doaj.art-bff61e1180a04e9aad997b6eb7ec163f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:44:22Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bff61e1180a04e9aad997b6eb7ec163f2023-11-22T03:24:41ZengMDPI AGCancers2072-66942021-07-011314352610.3390/cancers13143526Cancer-Associated Fibroblasts: Implications for Cancer TherapyAna Maia0Stefan Wiemann1German Cancer Research Center (DKFZ), Division of Molecular Genome Analysis, Im Neuenheimer Feld 580, 69120 Heidelberg, GermanyGerman Cancer Research Center (DKFZ), Division of Molecular Genome Analysis, Im Neuenheimer Feld 580, 69120 Heidelberg, GermanyTumour cells do not exist as an isolated entity. Instead, they are surrounded by and closely interact with cells of the environment they are emerged in. The tumour microenvironment (TME) is not static and several factors, including cancer cells and therapies, have been described to modulate several of its components. Fibroblasts are key elements of the TME with the capacity to influence tumour progression, invasion and response to therapy, which makes them attractive targets in cancer treatment. In this review, we focus on fibroblasts and their numerous roles in the TME with a special attention to recent findings describing their heterogeneity and role in therapy response. Furthermore, we explore how different therapies can impact these cells and their communication with cancer cells. Finally, we highlight potential strategies targeting this cell type that can be employed for improving patient outcome.https://www.mdpi.com/2072-6694/13/14/3526cancer associated fibroblast (CAF)tumour microenvironment (TME)cell communicationsignallingtherapy resistance |
| spellingShingle | Ana Maia Stefan Wiemann Cancer-Associated Fibroblasts: Implications for Cancer Therapy Cancers cancer associated fibroblast (CAF) tumour microenvironment (TME) cell communication signalling therapy resistance |
| title | Cancer-Associated Fibroblasts: Implications for Cancer Therapy |
| title_full | Cancer-Associated Fibroblasts: Implications for Cancer Therapy |
| title_fullStr | Cancer-Associated Fibroblasts: Implications for Cancer Therapy |
| title_full_unstemmed | Cancer-Associated Fibroblasts: Implications for Cancer Therapy |
| title_short | Cancer-Associated Fibroblasts: Implications for Cancer Therapy |
| title_sort | cancer associated fibroblasts implications for cancer therapy |
| topic | cancer associated fibroblast (CAF) tumour microenvironment (TME) cell communication signalling therapy resistance |
| url | https://www.mdpi.com/2072-6694/13/14/3526 |
| work_keys_str_mv | AT anamaia cancerassociatedfibroblastsimplicationsforcancertherapy AT stefanwiemann cancerassociatedfibroblastsimplicationsforcancertherapy |