Effects of non-steroidal anti-inflammatory drugs administered at different time points on the incidence of cystoid macular edema following phacoemulsification: a Meta-analysis
AIM: To systematically evaluate the effects of non-steroidal anti-inflammatory drugs(NSAIDs)administrated at different time points on the incidence of cystoid macular edema(CME)following phacoemulsification. <p>METHODS: The Cochrane Library, PubMed, BMC, National Knowledge Infrastructure(CNKI)...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2017-11-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2017/11/201711012.pdf |
| _version_ | 1819236375298310144 |
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| author | Li-Jun Wang Yi Zhang Xiao Xiao Lin Zhao Jian-Ming Wang |
| author_facet | Li-Jun Wang Yi Zhang Xiao Xiao Lin Zhao Jian-Ming Wang |
| author_sort | Li-Jun Wang |
| collection | DOAJ |
| description | AIM: To systematically evaluate the effects of non-steroidal anti-inflammatory drugs(NSAIDs)administrated at different time points on the incidence of cystoid macular edema(CME)following phacoemulsification. <p>METHODS: The Cochrane Library, PubMed, BMC, National Knowledge Infrastructure(CNKI), and VIP databases were searched to identify the clinical randomized controlled trials of comparing effects of NSAIDs administered at different time points on the incidence of CME and the central foveal thickness following phacoemulsification. The experiment group received topical NSAIDs preoperatively and postoperatively, while the control group received topical NSAIDs postoperatively. The RevMan software 5.2 and Stata software 12.0 were used in the Meta-analysis. <p>RESULTS: Six studies were included in this Meta-analysis. No statistically differences were observed in the incidence of CME after 1wk postoperatively(<i>OR</i>=1.58, <i>95%CI</i>: 0.48-5.18, <i>P</i>>0.05), in the incidence of CME after 1mo postoperatively(<i>OR</i>=0.78, <i>95%CI</i>: 0.30-2.00, <i>P</i>>0.05), in the central foveal thickness after 1wk postoperatively(<i>WMD</i>=-7.20, <i>95%CI</i>: -15.17 to 0.77, <i>P</i>>0.05), and in the central foveal thickness after 1mo postoperatively(<i>WMD</i>=-3.98, <i>95%CI</i>: -14.05 to 6.08, <i>P</i>>0.05). However, statistically significant differences were found in the incidence of CME after 3mo postoperatively<i> </i>(<i>OR</i>=0.22, <i>95%CI</i>: 0.11-0.43, <i>P<</i>0.01)and in the central foveal thickness after 3mo postoperatively(<i>WMD</i>=-18.25, <i>95%CI</i>: -33.80 to -2.70, <i>P<</i>0.05). <p>CONCLUSION: A combination of NSAIDs administrated preoperatively and postoperatively can reduce the incidence of the CME and the thickness of the macular centrall. Thereby, the effects of administrating NSAIDs both preoperatively and postoperatively have more advantages than that of administrating NSAIDs postoperatively alone. |
| first_indexed | 2024-12-23T13:03:26Z |
| format | Article |
| id | doaj.art-bff6d305015d45168f18ca61197f3703 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-23T13:03:26Z |
| publishDate | 2017-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-bff6d305015d45168f18ca61197f37032022-12-21T17:45:58ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232017-11-0117112040204410.3980/j.issn.1672-5123.2017.11.12Effects of non-steroidal anti-inflammatory drugs administered at different time points on the incidence of cystoid macular edema following phacoemulsification: a Meta-analysisLi-Jun Wang0Yi Zhang1Xiao Xiao2Lin Zhao3Jian-Ming Wang4Department of Ophthalmology, the Second Affiliated Hospital of Xi'an Jiaotong UniversityDepartment of Ophthalmology, the Second Affiliated Hospital of Xi'an Jiaotong UniversityDepartment of Ophthalmology, the Central Hospital, Xi'an 710004, Shaanxi Province, ChinaDepartment of Ophthalmology, the Second Affiliated Hospital of Xi'an Jiaotong UniversityDepartment of Ophthalmology, the Second Affiliated Hospital of Xi'an Jiaotong UniversityAIM: To systematically evaluate the effects of non-steroidal anti-inflammatory drugs(NSAIDs)administrated at different time points on the incidence of cystoid macular edema(CME)following phacoemulsification. <p>METHODS: The Cochrane Library, PubMed, BMC, National Knowledge Infrastructure(CNKI), and VIP databases were searched to identify the clinical randomized controlled trials of comparing effects of NSAIDs administered at different time points on the incidence of CME and the central foveal thickness following phacoemulsification. The experiment group received topical NSAIDs preoperatively and postoperatively, while the control group received topical NSAIDs postoperatively. The RevMan software 5.2 and Stata software 12.0 were used in the Meta-analysis. <p>RESULTS: Six studies were included in this Meta-analysis. No statistically differences were observed in the incidence of CME after 1wk postoperatively(<i>OR</i>=1.58, <i>95%CI</i>: 0.48-5.18, <i>P</i>>0.05), in the incidence of CME after 1mo postoperatively(<i>OR</i>=0.78, <i>95%CI</i>: 0.30-2.00, <i>P</i>>0.05), in the central foveal thickness after 1wk postoperatively(<i>WMD</i>=-7.20, <i>95%CI</i>: -15.17 to 0.77, <i>P</i>>0.05), and in the central foveal thickness after 1mo postoperatively(<i>WMD</i>=-3.98, <i>95%CI</i>: -14.05 to 6.08, <i>P</i>>0.05). However, statistically significant differences were found in the incidence of CME after 3mo postoperatively<i> </i>(<i>OR</i>=0.22, <i>95%CI</i>: 0.11-0.43, <i>P<</i>0.01)and in the central foveal thickness after 3mo postoperatively(<i>WMD</i>=-18.25, <i>95%CI</i>: -33.80 to -2.70, <i>P<</i>0.05). <p>CONCLUSION: A combination of NSAIDs administrated preoperatively and postoperatively can reduce the incidence of the CME and the thickness of the macular centrall. Thereby, the effects of administrating NSAIDs both preoperatively and postoperatively have more advantages than that of administrating NSAIDs postoperatively alone.http://ies.ijo.cn/cn_publish/2017/11/201711012.pdfnon-steroidal anti-inflammatory drugscataractphacoemulsificationcystoid macular edemacentral foveal thicknessMeta analysisMeta analysis |
| spellingShingle | Li-Jun Wang Yi Zhang Xiao Xiao Lin Zhao Jian-Ming Wang Effects of non-steroidal anti-inflammatory drugs administered at different time points on the incidence of cystoid macular edema following phacoemulsification: a Meta-analysis Guoji Yanke Zazhi non-steroidal anti-inflammatory drugs cataract phacoemulsification cystoid macular edema central foveal thickness Meta analysis Meta analysis |
| title | Effects of non-steroidal anti-inflammatory drugs administered at different time points on the incidence of cystoid macular edema following phacoemulsification: a Meta-analysis |
| title_full | Effects of non-steroidal anti-inflammatory drugs administered at different time points on the incidence of cystoid macular edema following phacoemulsification: a Meta-analysis |
| title_fullStr | Effects of non-steroidal anti-inflammatory drugs administered at different time points on the incidence of cystoid macular edema following phacoemulsification: a Meta-analysis |
| title_full_unstemmed | Effects of non-steroidal anti-inflammatory drugs administered at different time points on the incidence of cystoid macular edema following phacoemulsification: a Meta-analysis |
| title_short | Effects of non-steroidal anti-inflammatory drugs administered at different time points on the incidence of cystoid macular edema following phacoemulsification: a Meta-analysis |
| title_sort | effects of non steroidal anti inflammatory drugs administered at different time points on the incidence of cystoid macular edema following phacoemulsification a meta analysis |
| topic | non-steroidal anti-inflammatory drugs cataract phacoemulsification cystoid macular edema central foveal thickness Meta analysis Meta analysis |
| url | http://ies.ijo.cn/cn_publish/2017/11/201711012.pdf |
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