Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility
The role of impaired lung function in lung cancer etiology is complex due to the relation of cigarette smoking to both conditions. Here, supported by Mendelian randomization analysis the authors find a link between pulmonary function impairment and lung cancer risk beyond smoking, implicating immune...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13855-2 |
| _version_ | 1818994750126030848 |
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| author | Linda Kachuri Mattias Johansson Sara R. Rashkin Rebecca E. Graff Yohan Bossé Venkata Manem Neil E. Caporaso Maria Teresa Landi David C. Christiani Paolo Vineis Geoffrey Liu Ghislaine Scelo David Zaridze Sanjay S. Shete Demetrius Albanes Melinda C. Aldrich Adonina Tardón Gad Rennert Chu Chen Gary E. Goodman Jennifer A. Doherty Heike Bickeböller John K. Field Michael P. Davies M. Dawn Teare Lambertus A. Kiemeney Stig E. Bojesen Aage Haugen Shanbeh Zienolddiny Stephen Lam Loïc Le Marchand Iona Cheng Matthew B. Schabath Eric J. Duell Angeline S. Andrew Jonas Manjer Philip Lazarus Susanne Arnold James D. McKay Nima C. Emami Matthew T. Warkentin Yonathan Brhane Ma’en Obeidat Richard M. Martin Caroline Relton George Davey Smith Philip C. Haycock Christopher I. Amos Paul Brennan John S. Witte Rayjean J. Hung |
| author_facet | Linda Kachuri Mattias Johansson Sara R. Rashkin Rebecca E. Graff Yohan Bossé Venkata Manem Neil E. Caporaso Maria Teresa Landi David C. Christiani Paolo Vineis Geoffrey Liu Ghislaine Scelo David Zaridze Sanjay S. Shete Demetrius Albanes Melinda C. Aldrich Adonina Tardón Gad Rennert Chu Chen Gary E. Goodman Jennifer A. Doherty Heike Bickeböller John K. Field Michael P. Davies M. Dawn Teare Lambertus A. Kiemeney Stig E. Bojesen Aage Haugen Shanbeh Zienolddiny Stephen Lam Loïc Le Marchand Iona Cheng Matthew B. Schabath Eric J. Duell Angeline S. Andrew Jonas Manjer Philip Lazarus Susanne Arnold James D. McKay Nima C. Emami Matthew T. Warkentin Yonathan Brhane Ma’en Obeidat Richard M. Martin Caroline Relton George Davey Smith Philip C. Haycock Christopher I. Amos Paul Brennan John S. Witte Rayjean J. Hung |
| author_sort | Linda Kachuri |
| collection | DOAJ |
| description | The role of impaired lung function in lung cancer etiology is complex due to the relation of cigarette smoking to both conditions. Here, supported by Mendelian randomization analysis the authors find a link between pulmonary function impairment and lung cancer risk beyond smoking, implicating immune-related pathways |
| first_indexed | 2024-12-20T21:02:54Z |
| format | Article |
| id | doaj.art-bff7e82d5b6d44f0880ccdf00acf35df |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:02:54Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bff7e82d5b6d44f0880ccdf00acf35df2022-12-21T19:26:40ZengNature PortfolioNature Communications2041-17232020-01-0111111410.1038/s41467-019-13855-2Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibilityLinda Kachuri0Mattias Johansson1Sara R. Rashkin2Rebecca E. Graff3Yohan Bossé4Venkata Manem5Neil E. Caporaso6Maria Teresa Landi7David C. Christiani8Paolo Vineis9Geoffrey Liu10Ghislaine Scelo11David Zaridze12Sanjay S. Shete13Demetrius Albanes14Melinda C. Aldrich15Adonina Tardón16Gad Rennert17Chu Chen18Gary E. Goodman19Jennifer A. Doherty20Heike Bickeböller21John K. Field22Michael P. Davies23M. Dawn Teare24Lambertus A. Kiemeney25Stig E. Bojesen26Aage Haugen27Shanbeh Zienolddiny28Stephen Lam29Loïc Le Marchand30Iona Cheng31Matthew B. Schabath32Eric J. Duell33Angeline S. Andrew34Jonas Manjer35Philip Lazarus36Susanne Arnold37James D. McKay38Nima C. Emami39Matthew T. Warkentin40Yonathan Brhane41Ma’en Obeidat42Richard M. Martin43Caroline Relton44George Davey Smith45Philip C. Haycock46Christopher I. Amos47Paul Brennan48John S. Witte49Rayjean J. Hung50Department of Epidemiology & Biostatistics, University of California San FranciscoInternational Agency for Research on CancerDepartment of Epidemiology & Biostatistics, University of California San FranciscoDepartment of Epidemiology & Biostatistics, University of California San FranciscoInstitut universitaire de cardiologie et de pneumologie de Québec – Université LavalInstitut universitaire de cardiologie et de pneumologie de Québec – Université LavalDivision of Cancer Epidemiology & Genetics, US NCIDivision of Cancer Epidemiology & Genetics, US NCIDepartments of Environmental Health and Epidemiology, Harvard TH Chan School of Public HealthDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonPrincess Margaret Cancer Center, University Health NetworkInternational Agency for Research on CancerRussian N.N. Blokhin Cancer Research CentreDepartment of Biostatistics, Division of Basic Sciences, MD Anderson Cancer CenterDivision of Cancer Epidemiology & Genetics, US NCIDepartment of Thoracic Surgery and Division of Epidemiology, Vanderbilt University Medical CenterFaculty of Medicine, University of Oviedo and ISPA and CIBERESP, Campus del CristoClalit National Cancer Control Center, Technion Faculty of MedicineFred Hutchinson Cancer Research CenterFred Hutchinson Cancer Research CenterDepartment of Population Health Sciences, Huntsman Cancer InstituteDepartment of Genetic Epidemiology, University Medical Center, Georg-August-Universität GöttingenRoy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of LiverpoolRoy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of LiverpoolBiostatistics Research Group, Institute of Health and Society, Newcastle UniversityRadboud Institute for Health Sciences, Radboud University Medical CentreDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University HospitalThe National Institute of Occupational HealthThe National Institute of Occupational HealthBC Cancer AgencyEpidemiology Program, University of Hawaii Cancer CenterDepartment of Epidemiology & Biostatistics, University of California San FranciscoDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research InstituteUnit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL)Department of Epidemiology, Geisel School of Medicine, Dartmouth CollegeSkåne University Hospital, Lund UniversityDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State UniversityMarkey Cancer Center, University of KentuckyInternational Agency for Research on CancerDepartment of Epidemiology & Biostatistics, University of California San FranciscoProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health SystemProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health SystemUniversity of British Columbia, Centre for Heart Lung InnovationMRC Integrative Epidemiology Unit, University of BristolMRC Integrative Epidemiology Unit, University of BristolMRC Integrative Epidemiology Unit, University of BristolMRC Integrative Epidemiology Unit, University of BristolInstitute for Clinical and Translational Research, Baylor College of MedicineInternational Agency for Research on CancerDepartment of Epidemiology & Biostatistics, University of California San FranciscoProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health SystemThe role of impaired lung function in lung cancer etiology is complex due to the relation of cigarette smoking to both conditions. Here, supported by Mendelian randomization analysis the authors find a link between pulmonary function impairment and lung cancer risk beyond smoking, implicating immune-related pathwayshttps://doi.org/10.1038/s41467-019-13855-2 |
| spellingShingle | Linda Kachuri Mattias Johansson Sara R. Rashkin Rebecca E. Graff Yohan Bossé Venkata Manem Neil E. Caporaso Maria Teresa Landi David C. Christiani Paolo Vineis Geoffrey Liu Ghislaine Scelo David Zaridze Sanjay S. Shete Demetrius Albanes Melinda C. Aldrich Adonina Tardón Gad Rennert Chu Chen Gary E. Goodman Jennifer A. Doherty Heike Bickeböller John K. Field Michael P. Davies M. Dawn Teare Lambertus A. Kiemeney Stig E. Bojesen Aage Haugen Shanbeh Zienolddiny Stephen Lam Loïc Le Marchand Iona Cheng Matthew B. Schabath Eric J. Duell Angeline S. Andrew Jonas Manjer Philip Lazarus Susanne Arnold James D. McKay Nima C. Emami Matthew T. Warkentin Yonathan Brhane Ma’en Obeidat Richard M. Martin Caroline Relton George Davey Smith Philip C. Haycock Christopher I. Amos Paul Brennan John S. Witte Rayjean J. Hung Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility Nature Communications |
| title | Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| title_full | Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| title_fullStr | Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| title_full_unstemmed | Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| title_short | Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| title_sort | immune mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| url | https://doi.org/10.1038/s41467-019-13855-2 |
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