Evaluation of tissue repair using phytotherapeutic gel from Plectranthus neochilus, Schlechter (boldo-gambá) and Cnidoscolus quercifolius Pohl (favela) in Wistar rats
ABSTRACT The objective of this study was to investigate the effects of a gel formulation from the association of Plectranthus neochilus and Cnidoscolus quercifolius on tissue repair in cutaneous wounds in rats. A surgical wound was induced in 35 Wistar rats and treated according to group: G1 - comme...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Federal de Minas Gerais
2021-05-01
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| Series: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352021000200395&tlng=en |
| _version_ | 1828125145949011968 |
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| author | M.S.A. Rêgo E.S. Franco R.A.S. Oliveira L.A.V. Linden V.C.L. Silva C.S. Maia M.N. Teixeira M.L.M. Marinho E.R. Lima |
| author_facet | M.S.A. Rêgo E.S. Franco R.A.S. Oliveira L.A.V. Linden V.C.L. Silva C.S. Maia M.N. Teixeira M.L.M. Marinho E.R. Lima |
| author_sort | M.S.A. Rêgo |
| collection | DOAJ |
| description | ABSTRACT The objective of this study was to investigate the effects of a gel formulation from the association of Plectranthus neochilus and Cnidoscolus quercifolius on tissue repair in cutaneous wounds in rats. A surgical wound was induced in 35 Wistar rats and treated according to group: G1 - commercial phytotherapeutic gel; G2 - Carbopol gel 1%; G3, 4, 5 - gel formulation from Boldo-gambá and Favela (FGBF) at 2.5%, 5%, and 10%, respectively. 1ml of the product was applied topically daily, for 14 days. Macroscopic evaluation of the wound showed inflammation, granulation, and epithelization in all groups. The FGBF 2.5% group showed greater angiogenic potential. There was a significant difference between the surgical area of the wounds treated with FGBF 2.5%, 5%, or 10% compared to the group with the commercial phytotherapeutic gel. On histomorphometry of the skin, there were reepithelization of the epidermis and superficial dermis, longitudinal collagen fibers, fibroblasts, and blood vessels, and in the deeper dermis, fibroblasts, transverse and longitudinal collagen fibers, blood vessels, and inflammatory cells. The 2.5% formulation had the greatest increase in fibroblast proliferation and most intense collagenization on day 14 of treatment. |
| first_indexed | 2024-04-11T15:16:16Z |
| format | Article |
| id | doaj.art-bff8858bf2134e1ba0f4514912c9b467 |
| institution | Directory Open Access Journal |
| issn | 1678-4162 |
| language | English |
| last_indexed | 2024-04-11T15:16:16Z |
| publishDate | 2021-05-01 |
| publisher | Universidade Federal de Minas Gerais |
| record_format | Article |
| series | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| spelling | doaj.art-bff8858bf2134e1ba0f4514912c9b4672022-12-22T04:16:28ZengUniversidade Federal de Minas GeraisArquivo Brasileiro de Medicina Veterinária e Zootecnia1678-41622021-05-0173239540510.1590/1678-4162-12026Evaluation of tissue repair using phytotherapeutic gel from Plectranthus neochilus, Schlechter (boldo-gambá) and Cnidoscolus quercifolius Pohl (favela) in Wistar ratsM.S.A. Rêgohttps://orcid.org/0000-0002-6641-6100E.S. Francohttps://orcid.org/0000-0001-5864-7980R.A.S. Oliveirahttps://orcid.org/0000-0001-5864-6312L.A.V. Lindenhttps://orcid.org/0000-0003-4340-581XV.C.L. Silvahttps://orcid.org/0000-0001-7566-8193C.S. Maiahttps://orcid.org/0000-0002-4301-0319M.N. Teixeirahttps://orcid.org/0000-0001-6276-9665M.L.M. Marinhohttps://orcid.org/0000-0002-5374-9352E.R. Limahttps://orcid.org/0000-0003-3601-1628ABSTRACT The objective of this study was to investigate the effects of a gel formulation from the association of Plectranthus neochilus and Cnidoscolus quercifolius on tissue repair in cutaneous wounds in rats. A surgical wound was induced in 35 Wistar rats and treated according to group: G1 - commercial phytotherapeutic gel; G2 - Carbopol gel 1%; G3, 4, 5 - gel formulation from Boldo-gambá and Favela (FGBF) at 2.5%, 5%, and 10%, respectively. 1ml of the product was applied topically daily, for 14 days. Macroscopic evaluation of the wound showed inflammation, granulation, and epithelization in all groups. The FGBF 2.5% group showed greater angiogenic potential. There was a significant difference between the surgical area of the wounds treated with FGBF 2.5%, 5%, or 10% compared to the group with the commercial phytotherapeutic gel. On histomorphometry of the skin, there were reepithelization of the epidermis and superficial dermis, longitudinal collagen fibers, fibroblasts, and blood vessels, and in the deeper dermis, fibroblasts, transverse and longitudinal collagen fibers, blood vessels, and inflammatory cells. The 2.5% formulation had the greatest increase in fibroblast proliferation and most intense collagenization on day 14 of treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352021000200395&tlng=enphytotherapydermatologyhealing |
| spellingShingle | M.S.A. Rêgo E.S. Franco R.A.S. Oliveira L.A.V. Linden V.C.L. Silva C.S. Maia M.N. Teixeira M.L.M. Marinho E.R. Lima Evaluation of tissue repair using phytotherapeutic gel from Plectranthus neochilus, Schlechter (boldo-gambá) and Cnidoscolus quercifolius Pohl (favela) in Wistar rats Arquivo Brasileiro de Medicina Veterinária e Zootecnia phytotherapy dermatology healing |
| title | Evaluation of tissue repair using phytotherapeutic gel from Plectranthus neochilus, Schlechter (boldo-gambá) and Cnidoscolus quercifolius Pohl (favela) in Wistar rats |
| title_full | Evaluation of tissue repair using phytotherapeutic gel from Plectranthus neochilus, Schlechter (boldo-gambá) and Cnidoscolus quercifolius Pohl (favela) in Wistar rats |
| title_fullStr | Evaluation of tissue repair using phytotherapeutic gel from Plectranthus neochilus, Schlechter (boldo-gambá) and Cnidoscolus quercifolius Pohl (favela) in Wistar rats |
| title_full_unstemmed | Evaluation of tissue repair using phytotherapeutic gel from Plectranthus neochilus, Schlechter (boldo-gambá) and Cnidoscolus quercifolius Pohl (favela) in Wistar rats |
| title_short | Evaluation of tissue repair using phytotherapeutic gel from Plectranthus neochilus, Schlechter (boldo-gambá) and Cnidoscolus quercifolius Pohl (favela) in Wistar rats |
| title_sort | evaluation of tissue repair using phytotherapeutic gel from plectranthus neochilus schlechter boldo gamba and cnidoscolus quercifolius pohl favela in wistar rats |
| topic | phytotherapy dermatology healing |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352021000200395&tlng=en |
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