Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future
B cells and antibodies are indispensable for host immunity. Our understanding of the mechanistic processes that underpin how B cells operate has left an indelible mark on the field of clinical pathology, and recently has also dramatically reshaped the therapeutic landscape of diseases that were once...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/21/3353 |
| _version_ | 1797468802561081344 |
|---|---|
| author | Aisha Ahmed Elizabeth Lippner Aaruni Khanolkar |
| author_facet | Aisha Ahmed Elizabeth Lippner Aaruni Khanolkar |
| author_sort | Aisha Ahmed |
| collection | DOAJ |
| description | B cells and antibodies are indispensable for host immunity. Our understanding of the mechanistic processes that underpin how B cells operate has left an indelible mark on the field of clinical pathology, and recently has also dramatically reshaped the therapeutic landscape of diseases that were once considered incurable. Evaluating patients with primary immunodeficiency diseases (PID)/inborn errors of immunity (IEI) that primarily affect B cells, offers us an opportunity to further our understanding of how B cells develop, mature, function and, in certain instances, cause further disease. In this review we provide a brief compendium of IEI that principally affect B cells at defined stages of their developmental pathway, and also attempt to offer some educated viewpoints on how the management of these disorders could evolve over the years. |
| first_indexed | 2024-03-09T19:11:40Z |
| format | Article |
| id | doaj.art-bff938c86c034925b84b443a3191168e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T19:11:40Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bff938c86c034925b84b443a3191168e2023-11-24T04:07:20ZengMDPI AGCells2073-44092022-10-011121335310.3390/cells11213353Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the FutureAisha Ahmed0Elizabeth Lippner1Aaruni Khanolkar2Division of Allergy and Immunology, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USADivision of Allergy and Immunology, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USADepartment of Pathology, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USAB cells and antibodies are indispensable for host immunity. Our understanding of the mechanistic processes that underpin how B cells operate has left an indelible mark on the field of clinical pathology, and recently has also dramatically reshaped the therapeutic landscape of diseases that were once considered incurable. Evaluating patients with primary immunodeficiency diseases (PID)/inborn errors of immunity (IEI) that primarily affect B cells, offers us an opportunity to further our understanding of how B cells develop, mature, function and, in certain instances, cause further disease. In this review we provide a brief compendium of IEI that principally affect B cells at defined stages of their developmental pathway, and also attempt to offer some educated viewpoints on how the management of these disorders could evolve over the years.https://www.mdpi.com/2073-4409/11/21/3353B cellsimmunodeficiencyhumoral immunityinborn errors of immunity |
| spellingShingle | Aisha Ahmed Elizabeth Lippner Aaruni Khanolkar Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future Cells B cells immunodeficiency humoral immunity inborn errors of immunity |
| title | Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future |
| title_full | Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future |
| title_fullStr | Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future |
| title_full_unstemmed | Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future |
| title_short | Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future |
| title_sort | clinical aspects of b cell immunodeficiencies the past the present and the future |
| topic | B cells immunodeficiency humoral immunity inborn errors of immunity |
| url | https://www.mdpi.com/2073-4409/11/21/3353 |
| work_keys_str_mv | AT aishaahmed clinicalaspectsofbcellimmunodeficienciesthepastthepresentandthefuture AT elizabethlippner clinicalaspectsofbcellimmunodeficienciesthepastthepresentandthefuture AT aarunikhanolkar clinicalaspectsofbcellimmunodeficienciesthepastthepresentandthefuture |