Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study

Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study

Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/1...

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Bibliographic Details
Main Authors: Carolien N. H. Abheiden, Birgit S. Blomjous, Sylvia J. Kroese, Irene E. M. Bultink, Ruth D. E. Fritsch-Stork, A. Titia Lely, Marjon A. de Boer, Johanna I. P. de Vries
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Hypertension in Pregnancy
Subjects:
antiphospholipid syndrome
aspirin
hypertensive disorders of pregnancy
low-molecular-weight heparin
systemic lupus erythematosus
Online Access:http://dx.doi.org/10.1080/10641955.2016.1217337
Description
Summary:Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.
ISSN:1064-1955
1525-6065

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