Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study
Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/1...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2016.1217337 |
| _version_ | 1797681605258510336 |
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| author | Carolien N. H. Abheiden Birgit S. Blomjous Sylvia J. Kroese Irene E. M. Bultink Ruth D. E. Fritsch-Stork A. Titia Lely Marjon A. de Boer Johanna I. P. de Vries |
| author_facet | Carolien N. H. Abheiden Birgit S. Blomjous Sylvia J. Kroese Irene E. M. Bultink Ruth D. E. Fritsch-Stork A. Titia Lely Marjon A. de Boer Johanna I. P. de Vries |
| author_sort | Carolien N. H. Abheiden |
| collection | DOAJ |
| description | Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use. |
| first_indexed | 2024-03-11T23:47:21Z |
| format | Article |
| id | doaj.art-bffa171ad5c5472a8dec06fa467c12b7 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:47:21Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-bffa171ad5c5472a8dec06fa467c12b72023-09-19T09:24:41ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652017-01-0136181510.1080/10641955.2016.12173371217337Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort studyCarolien N. H. Abheiden0Birgit S. Blomjous1Sylvia J. Kroese2Irene E. M. Bultink3Ruth D. E. Fritsch-Stork4A. Titia Lely5Marjon A. de Boer6Johanna I. P. de Vries7VU University Medical CenterVU University Medical CenterUniversity Medical Center UtrechtAmsterdam Rheumatology and Immunology Center, VU University Medical CenterUniversity Medical Center UtrechtUniversity Medical Center UtrechtVU University Medical CenterVU University Medical CenterObjective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.http://dx.doi.org/10.1080/10641955.2016.1217337antiphospholipid syndromeaspirinhypertensive disorders of pregnancylow-molecular-weight heparinsystemic lupus erythematosus |
| spellingShingle | Carolien N. H. Abheiden Birgit S. Blomjous Sylvia J. Kroese Irene E. M. Bultink Ruth D. E. Fritsch-Stork A. Titia Lely Marjon A. de Boer Johanna I. P. de Vries Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study Hypertension in Pregnancy antiphospholipid syndrome aspirin hypertensive disorders of pregnancy low-molecular-weight heparin systemic lupus erythematosus |
| title | Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study |
| title_full | Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study |
| title_fullStr | Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study |
| title_full_unstemmed | Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study |
| title_short | Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study |
| title_sort | low molecular weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome a cohort study |
| topic | antiphospholipid syndrome aspirin hypertensive disorders of pregnancy low-molecular-weight heparin systemic lupus erythematosus |
| url | http://dx.doi.org/10.1080/10641955.2016.1217337 |
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