Quantitative 3D microscopy highlights altered von Willebrand factor α‐granule storage in patients with von Willebrand disease with distinct pathogenic mechanisms

Quantitative 3D microscopy highlights altered von Willebrand factor α‐granule storage in patients with von Willebrand disease with distinct pathogenic mechanisms

Abstract Background Platelets play a key role in hemostasis through plug formation and secretion of their granule contents at sites of endothelial injury. Defects in von Willebrand factor (VWF), a platelet α‐granule protein, are implicated in von Willebrand disease (VWD), and may lead to defective p...

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Bibliographic Details
Main Authors: Maurice Swinkels, Ferdows Atiq, Petra E. Bürgisser, Johan A. Slotman, Adriaan B. Houtsmuller, Cilia deHeus, Judith Klumperman, Frank W. G. Leebeek, Jan Voorberg, Arend Jan Gerard Jansen, Ruben Bierings
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
blood platelets
optical imaging
type 3
von Willebrand disease
von Willebrand factor
Online Access:https://doi.org/10.1002/rth2.12595

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