Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease

Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease

CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response. Somatic mutations in CARD11 are frequently found in Non-Hodgkin lymphoma, and at least three classes of germline CARD11 mutations have been described as the basis for...

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Bibliographic Details
Main Authors: Jacquelyn R. Bedsaul, Nicole M. Carter, Katelynn E. Deibel, Shelby M. Hutcherson, Tyler A. Jones, Zhaoquan Wang, Chao Yang, Yong-Kang Yang, Joel L. Pomerantz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
CARD11
Bcl10
MALT1
primary immunodeficiency
lymphoma
T cell receptor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02105/full

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