Synergies with and Resistance to Membrane-Active Peptides
Membrane-active peptides (MAPs) have long been thought of as the key to defeating antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In this review, we seek to highlight some of the common pathways for resistance, as well as some avenues for potential synerg...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/9/9/620 |
| _version_ | 1827705885957292032 |
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| author | Adam Kmeck Robert J. Tancer Cristina R. Ventura Gregory R. Wiedman |
| author_facet | Adam Kmeck Robert J. Tancer Cristina R. Ventura Gregory R. Wiedman |
| author_sort | Adam Kmeck |
| collection | DOAJ |
| description | Membrane-active peptides (MAPs) have long been thought of as the key to defeating antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In this review, we seek to highlight some of the common pathways for resistance, as well as some avenues for potential synergy. This discussion takes place considering resistance, and/or synergy in the extracellular space, at the membrane, and during interaction, and/or removal. Overall, this review shows that researchers require improved definitions of resistance and a more thorough understanding of MAP-resistance mechanisms. The solution to combating resistance may ultimately come from an understanding of how to harness the power of synergistic drug combinations. |
| first_indexed | 2024-03-10T16:12:58Z |
| format | Article |
| id | doaj.art-bffd393ee06843ef8d32edee6e86c3e3 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T16:12:58Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-bffd393ee06843ef8d32edee6e86c3e32023-11-20T14:18:55ZengMDPI AGAntibiotics2079-63822020-09-019962010.3390/antibiotics9090620Synergies with and Resistance to Membrane-Active PeptidesAdam Kmeck0Robert J. Tancer1Cristina R. Ventura2Gregory R. Wiedman3Department of Chemistry and Biochemistry, Seton Hall University, South Orange, NJ 07079, USADepartment of Chemistry and Biochemistry, Seton Hall University, South Orange, NJ 07079, USADepartment of Chemistry and Biochemistry, Seton Hall University, South Orange, NJ 07079, USADepartment of Chemistry and Biochemistry, Seton Hall University, South Orange, NJ 07079, USAMembrane-active peptides (MAPs) have long been thought of as the key to defeating antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In this review, we seek to highlight some of the common pathways for resistance, as well as some avenues for potential synergy. This discussion takes place considering resistance, and/or synergy in the extracellular space, at the membrane, and during interaction, and/or removal. Overall, this review shows that researchers require improved definitions of resistance and a more thorough understanding of MAP-resistance mechanisms. The solution to combating resistance may ultimately come from an understanding of how to harness the power of synergistic drug combinations.https://www.mdpi.com/2079-6382/9/9/620membrane-active peptidesantimicrobial-resistancedrug synergy |
| spellingShingle | Adam Kmeck Robert J. Tancer Cristina R. Ventura Gregory R. Wiedman Synergies with and Resistance to Membrane-Active Peptides Antibiotics membrane-active peptides antimicrobial-resistance drug synergy |
| title | Synergies with and Resistance to Membrane-Active Peptides |
| title_full | Synergies with and Resistance to Membrane-Active Peptides |
| title_fullStr | Synergies with and Resistance to Membrane-Active Peptides |
| title_full_unstemmed | Synergies with and Resistance to Membrane-Active Peptides |
| title_short | Synergies with and Resistance to Membrane-Active Peptides |
| title_sort | synergies with and resistance to membrane active peptides |
| topic | membrane-active peptides antimicrobial-resistance drug synergy |
| url | https://www.mdpi.com/2079-6382/9/9/620 |
| work_keys_str_mv | AT adamkmeck synergieswithandresistancetomembraneactivepeptides AT robertjtancer synergieswithandresistancetomembraneactivepeptides AT cristinarventura synergieswithandresistancetomembraneactivepeptides AT gregoryrwiedman synergieswithandresistancetomembraneactivepeptides |