Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkisnsonism
Background. Magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) VIM-thalamotomy has established efficacy and safety in tremor relief in patients with essential tremor and Parkinson’s disease. The efficacy and safety in patients with atypical parkinsonism have not been reported. Objectiv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2024-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2024/6643510 |
| _version_ | 1797263758820638720 |
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| author | Alon Sinai Maria Nassar Lev Shornikov Marius Constantinescu Menashe Zaaroor Ilana Schlesinger |
| author_facet | Alon Sinai Maria Nassar Lev Shornikov Marius Constantinescu Menashe Zaaroor Ilana Schlesinger |
| author_sort | Alon Sinai |
| collection | DOAJ |
| description | Background. Magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) VIM-thalamotomy has established efficacy and safety in tremor relief in patients with essential tremor and Parkinson’s disease. The efficacy and safety in patients with atypical parkinsonism have not been reported. Objective. To report on the efficacy and safety of FUS VIM-thalamotomy in 8 patients with parkinsonism, multiple system atrophy-Parkinsonian type (MSA-P) (n = 5), and dementia with Lewy bodies (DLB) (n = 3). Methods. Tremor was assessed in the treated hemibody using the Clinical Rating Scale for Tremor (CRST). The motor Unified MSA Rating Scale (UMSAR) was used in the MSA-P and motor sections of the Unified Parkinson’s Disease Rating Scale (UPDRS-III) in DLB patients. Cognition was measured using the Montreal Cognitive Assessment (MoCA). Results. In MSA-P and DLB patients, there was immediate tremor relief. CRST scores measured on the treated side improved compared to baseline. During the follow-up of up to 1 year tremor reduction persisted. The change in CRST scores at different time points did not reach statistical significance, probably due to the small sample size. Adverse events were transient and resolved within a year. Conclusions. In our experience, FUS VIM-thalamotomy was effective in patients with MSA-P and DLB. Larger, controlled studies are needed to verify our preliminary observations. |
| first_indexed | 2024-04-25T00:18:06Z |
| format | Article |
| id | doaj.art-bffd6b898fb748d68ab932741d8fdf47 |
| institution | Directory Open Access Journal |
| issn | 2042-0080 |
| language | English |
| last_indexed | 2024-04-25T00:18:06Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj.art-bffd6b898fb748d68ab932741d8fdf472024-03-13T00:00:02ZengHindawi LimitedParkinson's Disease2042-00802024-01-01202410.1155/2024/6643510Focused Ultrasound Thalamotomy for Tremor Relief in Atypical ParkisnsonismAlon Sinai0Maria Nassar1Lev Shornikov2Marius Constantinescu3Menashe Zaaroor4Ilana Schlesinger5Department of NeurosurgeryDepartment of NeurologyDepartment of NeurologyDepartment of NeurosurgeryDepartment of NeurosurgeryDepartment of NeurologyBackground. Magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) VIM-thalamotomy has established efficacy and safety in tremor relief in patients with essential tremor and Parkinson’s disease. The efficacy and safety in patients with atypical parkinsonism have not been reported. Objective. To report on the efficacy and safety of FUS VIM-thalamotomy in 8 patients with parkinsonism, multiple system atrophy-Parkinsonian type (MSA-P) (n = 5), and dementia with Lewy bodies (DLB) (n = 3). Methods. Tremor was assessed in the treated hemibody using the Clinical Rating Scale for Tremor (CRST). The motor Unified MSA Rating Scale (UMSAR) was used in the MSA-P and motor sections of the Unified Parkinson’s Disease Rating Scale (UPDRS-III) in DLB patients. Cognition was measured using the Montreal Cognitive Assessment (MoCA). Results. In MSA-P and DLB patients, there was immediate tremor relief. CRST scores measured on the treated side improved compared to baseline. During the follow-up of up to 1 year tremor reduction persisted. The change in CRST scores at different time points did not reach statistical significance, probably due to the small sample size. Adverse events were transient and resolved within a year. Conclusions. In our experience, FUS VIM-thalamotomy was effective in patients with MSA-P and DLB. Larger, controlled studies are needed to verify our preliminary observations.http://dx.doi.org/10.1155/2024/6643510 |
| spellingShingle | Alon Sinai Maria Nassar Lev Shornikov Marius Constantinescu Menashe Zaaroor Ilana Schlesinger Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkisnsonism Parkinson's Disease |
| title | Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkisnsonism |
| title_full | Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkisnsonism |
| title_fullStr | Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkisnsonism |
| title_full_unstemmed | Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkisnsonism |
| title_short | Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkisnsonism |
| title_sort | focused ultrasound thalamotomy for tremor relief in atypical parkisnsonism |
| url | http://dx.doi.org/10.1155/2024/6643510 |
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