RNA editing – Systemic relevance and clue to disease mechanisms?
Recent advances in sequencing technologies led to the identification of a plethora of different genes and several hundreds of amino acid recoding edited positions. Changes in editing rates of some of these positions were associated with diseases such as atherosclerosis, myopathy, epilepsy, major dep...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00124/full |
| _version_ | 1819149212570353664 |
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| author | Jochen C Meier Svenja Kankowski Heinz Krestel Florian Hetsch |
| author_facet | Jochen C Meier Svenja Kankowski Heinz Krestel Florian Hetsch |
| author_sort | Jochen C Meier |
| collection | DOAJ |
| description | Recent advances in sequencing technologies led to the identification of a plethora of different genes and several hundreds of amino acid recoding edited positions. Changes in editing rates of some of these positions were associated with diseases such as atherosclerosis, myopathy, epilepsy, major depression disorder, schizophrenia and other mood disorders as well as cancer and brain tumors. This review summarizes our current knowledge on that front and presents glycine receptor C-to-U RNA editing as a first example of disease-associated increased RNA editing that includes assessment of disease mechanisms of the corresponding gene product in an animal model. |
| first_indexed | 2024-12-22T13:58:01Z |
| format | Article |
| id | doaj.art-bffe8a580b3044c19358c757641d8663 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-22T13:58:01Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-bffe8a580b3044c19358c757641d86632022-12-21T18:23:30ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992016-11-01910.3389/fnmol.2016.00124230252RNA editing – Systemic relevance and clue to disease mechanisms?Jochen C Meier0Svenja Kankowski1Heinz Krestel2Florian Hetsch3Technical University BraunschweigTechnical University BraunschweigUniversitätsspital BernTechnical University BraunschweigRecent advances in sequencing technologies led to the identification of a plethora of different genes and several hundreds of amino acid recoding edited positions. Changes in editing rates of some of these positions were associated with diseases such as atherosclerosis, myopathy, epilepsy, major depression disorder, schizophrenia and other mood disorders as well as cancer and brain tumors. This review summarizes our current knowledge on that front and presents glycine receptor C-to-U RNA editing as a first example of disease-associated increased RNA editing that includes assessment of disease mechanisms of the corresponding gene product in an animal model.http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00124/fullApolipoproteinsAtherosclerosisEpilepsyGlioblastomaPotassium ChannelsRNA Editing |
| spellingShingle | Jochen C Meier Svenja Kankowski Heinz Krestel Florian Hetsch RNA editing – Systemic relevance and clue to disease mechanisms? Frontiers in Molecular Neuroscience Apolipoproteins Atherosclerosis Epilepsy Glioblastoma Potassium Channels RNA Editing |
| title | RNA editing – Systemic relevance and clue to disease mechanisms? |
| title_full | RNA editing – Systemic relevance and clue to disease mechanisms? |
| title_fullStr | RNA editing – Systemic relevance and clue to disease mechanisms? |
| title_full_unstemmed | RNA editing – Systemic relevance and clue to disease mechanisms? |
| title_short | RNA editing – Systemic relevance and clue to disease mechanisms? |
| title_sort | rna editing systemic relevance and clue to disease mechanisms |
| topic | Apolipoproteins Atherosclerosis Epilepsy Glioblastoma Potassium Channels RNA Editing |
| url | http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00124/full |
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