The prognostic value of the change in the level of inflammatory markers in stable coronary artery patients with stent implanted
Vascular inflammation has a pivotal role in the progression of atherosclerosis and major cardiovascular events (MACE). However, there is limited data concerning to role of changes in inflammatory markers in predicting MACE. In the current study, it was investigated whether the difference between hig...
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| Format: | Article |
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Society of Turaz Bilim
2023-06-01
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| Series: | Medicine Science |
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| Online Access: | https://www.medicinescience.org/?mno=145414 |
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| author | Fatih Koca Fatih Levent Gokhan Ozmen Barıs Sensoy Mustafa Aldemir Mehmet Demir Erhan Tenekecioglu |
| author_facet | Fatih Koca Fatih Levent Gokhan Ozmen Barıs Sensoy Mustafa Aldemir Mehmet Demir Erhan Tenekecioglu |
| author_sort | Fatih Koca |
| collection | DOAJ |
| description | Vascular inflammation has a pivotal role in the progression of atherosclerosis and major cardiovascular events (MACE). However, there is limited data concerning to role of changes in inflammatory markers in predicting MACE. In the current study, it was investigated whether the difference between high sensitive C-Reactive Protein (hs-CRP) and systemic immune-inflammatory index values (Δhs CRP and ΔSII) measured before and after the procedure and residual SYNTAX score (rSS) in stable coronary artery patients underwent percutaneous coronary intervention (PCI) could predict MACE. 203 patients (mean age: 62.11±9.20, 75% male) were included in the study. Before the first procedure and at the 1st month after the procedure(s), their blood was drawn. rSS was calculated. MACE was determined as cardiovascular mortality, target vessel revascularization non-fatal myocardial infarction, and ischemic stroke. MACE was observed in 20 patients (9.9%). Of these patients, 3 (1.5%) had cardiovascular mortality, 3 (1.5%) had a non-fatal myocardial infarction, 12 (5.9%) had target vessel revascularization due to unstable angina, and the remaining 2 (1.0%) had an ischemic stroke. The area under the curve (AUC) to predict MACE diagnosis was 0.548 for ΔSII and 0.647 for Δhs-CRP and 0.766 for rSS. In multiple regression analysis, only rSS > 4 was an independent predictor for MACE (HR=3.41, 95% CI: 1.39-8.35, p=0.007). The change in SII and hs-CRP after PCI was found to be insufficient to predict MACE, while rSS was the only independent predictor for MACE. [Med-Science 2023; 12(2.000): 536-41] |
| first_indexed | 2024-03-08T03:19:58Z |
| format | Article |
| id | doaj.art-bfff623996f148c980c4d9cb1e416835 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T03:19:58Z |
| publishDate | 2023-06-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-bfff623996f148c980c4d9cb1e4168352024-02-12T10:33:28ZengSociety of Turaz BilimMedicine Science2147-06342023-06-011225364110.5455/medscience.2023.03.034145414The prognostic value of the change in the level of inflammatory markers in stable coronary artery patients with stent implantedFatih Koca0Fatih Levent1Gokhan Ozmen2Barıs Sensoy3Mustafa Aldemir4Mehmet Demir5Erhan Tenekecioglu6Bursa Yuksek İhtisas Training and Research Hospital, Depertment of Cardiology Bursa Yuksek İhtisas Training and Research Hospital, Depertment of Cardiology Bursa Yuksek İhtisas Training and Research Hospital, Depertment of Cardiology Bursa Yuksek İhtisas Training and Research Hospital, Depertment of Cardiology Bursa Yuksek İhtisas Training and Research Hospital, Depertment of Cardiovascular Surgery Bursa Yuksek İhtisas Training and Research Hospital, Depertment of Cardiology Bursa Yuksek İhtisas Training and Research Hospital, Depertment of CardiologyVascular inflammation has a pivotal role in the progression of atherosclerosis and major cardiovascular events (MACE). However, there is limited data concerning to role of changes in inflammatory markers in predicting MACE. In the current study, it was investigated whether the difference between high sensitive C-Reactive Protein (hs-CRP) and systemic immune-inflammatory index values (Δhs CRP and ΔSII) measured before and after the procedure and residual SYNTAX score (rSS) in stable coronary artery patients underwent percutaneous coronary intervention (PCI) could predict MACE. 203 patients (mean age: 62.11±9.20, 75% male) were included in the study. Before the first procedure and at the 1st month after the procedure(s), their blood was drawn. rSS was calculated. MACE was determined as cardiovascular mortality, target vessel revascularization non-fatal myocardial infarction, and ischemic stroke. MACE was observed in 20 patients (9.9%). Of these patients, 3 (1.5%) had cardiovascular mortality, 3 (1.5%) had a non-fatal myocardial infarction, 12 (5.9%) had target vessel revascularization due to unstable angina, and the remaining 2 (1.0%) had an ischemic stroke. The area under the curve (AUC) to predict MACE diagnosis was 0.548 for ΔSII and 0.647 for Δhs-CRP and 0.766 for rSS. In multiple regression analysis, only rSS > 4 was an independent predictor for MACE (HR=3.41, 95% CI: 1.39-8.35, p=0.007). The change in SII and hs-CRP after PCI was found to be insufficient to predict MACE, while rSS was the only independent predictor for MACE. [Med-Science 2023; 12(2.000): 536-41]https://www.medicinescience.org/?mno=145414inflammationhigh-sensitive crpsystemic immune inflammation indexresidual syntax scorestenting |
| spellingShingle | Fatih Koca Fatih Levent Gokhan Ozmen Barıs Sensoy Mustafa Aldemir Mehmet Demir Erhan Tenekecioglu The prognostic value of the change in the level of inflammatory markers in stable coronary artery patients with stent implanted Medicine Science inflammation high-sensitive crp systemic immune inflammation index residual syntax score stenting |
| title | The prognostic value of the change in the level of inflammatory markers in stable coronary artery patients with stent implanted |
| title_full | The prognostic value of the change in the level of inflammatory markers in stable coronary artery patients with stent implanted |
| title_fullStr | The prognostic value of the change in the level of inflammatory markers in stable coronary artery patients with stent implanted |
| title_full_unstemmed | The prognostic value of the change in the level of inflammatory markers in stable coronary artery patients with stent implanted |
| title_short | The prognostic value of the change in the level of inflammatory markers in stable coronary artery patients with stent implanted |
| title_sort | prognostic value of the change in the level of inflammatory markers in stable coronary artery patients with stent implanted |
| topic | inflammation high-sensitive crp systemic immune inflammation index residual syntax score stenting |
| url | https://www.medicinescience.org/?mno=145414 |
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