Anti-EGFR Therapy Induces EGF Secretion by Cancer-Associated Fibroblasts to Confer Colorectal Cancer Chemoresistance

Anti-EGFR Therapy Induces EGF Secretion by Cancer-Associated Fibroblasts to Confer Colorectal Cancer Chemoresistance

Targeted agents have improved the efficacy of chemotherapy for cancer patients, however, there remains a lack of understanding of how these therapies affect the unsuspecting bystanders of the stromal microenvironment. Cetuximab, a monoclonal antibody therapy targeting the epidermal growth factor rec...

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Bibliographic Details
Main Authors: Colleen M. Garvey, Roy Lau, Alyssa Sanchez, Ren X. Sun, Emma J. Fong, Michael E. Doche, Oscar Chen, Anthony Jusuf, Heinz-Josef Lenz, Brent Larson, Shannon M. Mumenthaler
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
colorectal cancer
cancer-associated fibroblasts
epidermal growth factor
cetuximab
drug-resistance
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/12/6/1393

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