Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release
There are many challenges in delivering active pharmaceutical ingredients from biomaterials, including retention of payload activity, accurate temporal release, and precise spatial administration, to name only a few. With our constantly increasing knowledge of biology and physiology, pathologies tha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Nanotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnano.2022.999923/full |
| _version_ | 1811181353012559872 |
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| author | Lucía Morillas-Becerill Luisa De Cola Luisa De Cola Jonathan M. Zuidema Jonathan M. Zuidema |
| author_facet | Lucía Morillas-Becerill Luisa De Cola Luisa De Cola Jonathan M. Zuidema Jonathan M. Zuidema |
| author_sort | Lucía Morillas-Becerill |
| collection | DOAJ |
| description | There are many challenges in delivering active pharmaceutical ingredients from biomaterials, including retention of payload activity, accurate temporal release, and precise spatial administration, to name only a few. With our constantly increasing knowledge of biology and physiology, pathologies that require therapeutic interventions are becoming more understood. While the desired temporal and spatial administration of a therapy might be theorized, the ability to deliver an active therapeutic in a precise location during a specific time frame is often challenging. This has led researchers to develop hybrid biomaterials containing inorganic nanoparticles in order to combine the advantages of both inorganics and organics in payload delivery applications. Organic materials have many beneficial properties, including the ability to form networks and matrices to create three-dimensional structures from the nanometer to centimeter scale, biodegradability, the versatility to use both synthetic and natural precursors, and ease of chemical modifications, while inorganic materials offer highly controllable nanoscale features, can entrap and protect therapeutics, and have degradation properties that can be tightly regulated. Here in, we discuss the current state-of-the-art in active pharmaceutical ingredient delivery from biomaterial hybrids, demonstrate the added levels of control that these hybrid biomaterials offer, and give our perspective on future innovations in the field. |
| first_indexed | 2024-04-11T09:16:19Z |
| format | Article |
| id | doaj.art-c007a28b56134f2dbb042ad485098ecf |
| institution | Directory Open Access Journal |
| issn | 2673-3013 |
| language | English |
| last_indexed | 2024-04-11T09:16:19Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nanotechnology |
| spelling | doaj.art-c007a28b56134f2dbb042ad485098ecf2022-12-22T04:32:20ZengFrontiers Media S.A.Frontiers in Nanotechnology2673-30132022-10-01410.3389/fnano.2022.999923999923Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload releaseLucía Morillas-Becerill0Luisa De Cola1Luisa De Cola2Jonathan M. Zuidema3Jonathan M. Zuidema4Dipartimento di Scienze Farmaceutiche, Universitá Degli Studi di Milano, Milan, ItalyDipartimento di Scienze Farmaceutiche, Universitá Degli Studi di Milano, Milan, ItalyDepartment of Molecular Chemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, ItalyDipartimento di Scienze Farmaceutiche, Universitá Degli Studi di Milano, Milan, ItalyDepartment of Molecular Chemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, ItalyThere are many challenges in delivering active pharmaceutical ingredients from biomaterials, including retention of payload activity, accurate temporal release, and precise spatial administration, to name only a few. With our constantly increasing knowledge of biology and physiology, pathologies that require therapeutic interventions are becoming more understood. While the desired temporal and spatial administration of a therapy might be theorized, the ability to deliver an active therapeutic in a precise location during a specific time frame is often challenging. This has led researchers to develop hybrid biomaterials containing inorganic nanoparticles in order to combine the advantages of both inorganics and organics in payload delivery applications. Organic materials have many beneficial properties, including the ability to form networks and matrices to create three-dimensional structures from the nanometer to centimeter scale, biodegradability, the versatility to use both synthetic and natural precursors, and ease of chemical modifications, while inorganic materials offer highly controllable nanoscale features, can entrap and protect therapeutics, and have degradation properties that can be tightly regulated. Here in, we discuss the current state-of-the-art in active pharmaceutical ingredient delivery from biomaterial hybrids, demonstrate the added levels of control that these hybrid biomaterials offer, and give our perspective on future innovations in the field.https://www.frontiersin.org/articles/10.3389/fnano.2022.999923/fullhybrid biomaterialsinorganic nanoparticlesdrug deliveryhydrogelspolymer scaffoldssilica nanoparticles |
| spellingShingle | Lucía Morillas-Becerill Luisa De Cola Luisa De Cola Jonathan M. Zuidema Jonathan M. Zuidema Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release Frontiers in Nanotechnology hybrid biomaterials inorganic nanoparticles drug delivery hydrogels polymer scaffolds silica nanoparticles |
| title | Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release |
| title_full | Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release |
| title_fullStr | Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release |
| title_full_unstemmed | Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release |
| title_short | Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release |
| title_sort | inorganic nanoparticle empowered biomaterial hybrids engineered payload release |
| topic | hybrid biomaterials inorganic nanoparticles drug delivery hydrogels polymer scaffolds silica nanoparticles |
| url | https://www.frontiersin.org/articles/10.3389/fnano.2022.999923/full |
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