The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor
PDE4B was previously shown to be a dominant PDE4 subtype of neutrophils. However, its physiological role in the neutrophil function has not been evaluated. In this study, the inhibitory effects of a phosphodiesterase 4B (PDE4B)- selective inhibitor (compound A) and subtype non-selective PDE4 inhibit...
Main Authors: | Suzuki Osamu, Goto Taiji, Yoshino Toshiharu, Nakamura Satoshi, Maeda Hiroaki |
---|---|
Format: | Article |
Language: | English |
Published: |
Sciendo
2015-06-01
|
Series: | Acta Pharmaceutica |
Subjects: | |
Online Access: | https://doi.org/10.1515/acph-2015-0016 |
Similar Items
-
Clinical Implication of Phosphodiesterase-4-Inhibition
by: Martin Alexander Schick, et al.
Published: (2022-01-01) -
Roflumilast: Review of Phosphodiesterase-4 Inhibitor as Asthma Therapy
by: Rafina Syfridiana, et al.
Published: (2021-08-01) -
Phosphodiesterase-4 Inhibition in Psoriasis
by: Milakovic M, et al.
Published: (2021-03-01) -
Phosphodiesterase 4B: Master Regulator of Brain Signaling
by: Amy J. Tibbo, et al.
Published: (2020-05-01) -
Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics
by: Simon J MacKenzie
Published: (2004-01-01)