Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study
Dysbiosis of gut microbiota (GM) has been involved in the pathophysiology of arterial hypertension (HT), via a putative role of short chain fatty acids (SCFAs). Its role in the circadian regulation of blood pressure (BP), also called “the dipping profile”, has been poorly investigated. Sixteen male...
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| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/5/282 |
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| author | Justine Huart Arianna Cirillo Bernard Taminiau Julie Descy Annie Saint-Remy Georges Daube Jean-Marie Krzesinski Pierrette Melin Pascal de Tullio François Jouret |
| author_facet | Justine Huart Arianna Cirillo Bernard Taminiau Julie Descy Annie Saint-Remy Georges Daube Jean-Marie Krzesinski Pierrette Melin Pascal de Tullio François Jouret |
| author_sort | Justine Huart |
| collection | DOAJ |
| description | Dysbiosis of gut microbiota (GM) has been involved in the pathophysiology of arterial hypertension (HT), via a putative role of short chain fatty acids (SCFAs). Its role in the circadian regulation of blood pressure (BP), also called “the dipping profile”, has been poorly investigated. Sixteen male volunteers and 10 female partners were subjected to 24 h ambulatory BP monitoring and were categorized in normotensive (NT) versus HT, as well as in dippers versus non-dippers. Nuclear magnetic resonance (NMR)-based metabolomics was performed on stool samples. A 5-year comparative follow-up of BP profiles and stool metabolomes was done in men. Significant correlations between stool metabolome and 24 h mean BP levels were found in both male and female cohorts and in the entire cohort (R<sup>2</sup> = 0.72, R<sup>2</sup> = 0.79, and R<sup>2</sup> = 0.45, respectively). Multivariate analysis discriminated dippers versus non-dippers in both male and female cohorts and in the entire cohort (Q<sup>2</sup> = 0.87, Q<sup>2</sup> = 0.98, and Q<sup>2</sup> = 0.68, respectively). Fecal amounts of acetate, propionate, and butyrate were higher in HT versus NT patients (<i>p</i> = 0.027; <i>p</i> = 0.015 and <i>p</i> = 0.015, respectively), as well as in non-dippers versus dippers (<i>p</i> = 0.027, <i>p</i> = 0.038, and <i>p</i> = 0.036, respectively) in the entire cohort. SCFA levels were significantly different in patients changing of dipping status over the 5-year follow-up. In conclusion, stool metabolome changes upon global and circadian BP profiles in both genders. |
| first_indexed | 2024-03-10T11:51:29Z |
| format | Article |
| id | doaj.art-c0087106274544b59080abb6c3f7bceb |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T11:51:29Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-c0087106274544b59080abb6c3f7bceb2023-11-21T17:42:47ZengMDPI AGMetabolites2218-19892021-04-0111528210.3390/metabo11050282Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal StudyJustine Huart0Arianna Cirillo1Bernard Taminiau2Julie Descy3Annie Saint-Remy4Georges Daube5Jean-Marie Krzesinski6Pierrette Melin7Pascal de Tullio8François Jouret9Division of Nephrology, University of Liège Hospital (ULg CHU), University of Liège, B-4000 Liège, BelgiumCenter for Interdisciplinary Research on Medicines (CIRM), Metabolomics Group, University of Liège, B-4000 Liège, BelgiumFundamental and Applied Research Center for Animal & Health (FARAH), Veterinary Public Health, University of Liège, B-4000 Liège, BelgiumClinical Microbiology, University of Liège Hospital (ULg CHU), University of Liège, B-4000 Liège, BelgiumDivision of Nephrology, University of Liège Hospital (ULg CHU), University of Liège, B-4000 Liège, BelgiumFundamental and Applied Research Center for Animal & Health (FARAH), Veterinary Public Health, University of Liège, B-4000 Liège, BelgiumDivision of Nephrology, University of Liège Hospital (ULg CHU), University of Liège, B-4000 Liège, BelgiumClinical Microbiology, University of Liège Hospital (ULg CHU), University of Liège, B-4000 Liège, BelgiumCenter for Interdisciplinary Research on Medicines (CIRM), Metabolomics Group, University of Liège, B-4000 Liège, BelgiumDivision of Nephrology, University of Liège Hospital (ULg CHU), University of Liège, B-4000 Liège, BelgiumDysbiosis of gut microbiota (GM) has been involved in the pathophysiology of arterial hypertension (HT), via a putative role of short chain fatty acids (SCFAs). Its role in the circadian regulation of blood pressure (BP), also called “the dipping profile”, has been poorly investigated. Sixteen male volunteers and 10 female partners were subjected to 24 h ambulatory BP monitoring and were categorized in normotensive (NT) versus HT, as well as in dippers versus non-dippers. Nuclear magnetic resonance (NMR)-based metabolomics was performed on stool samples. A 5-year comparative follow-up of BP profiles and stool metabolomes was done in men. Significant correlations between stool metabolome and 24 h mean BP levels were found in both male and female cohorts and in the entire cohort (R<sup>2</sup> = 0.72, R<sup>2</sup> = 0.79, and R<sup>2</sup> = 0.45, respectively). Multivariate analysis discriminated dippers versus non-dippers in both male and female cohorts and in the entire cohort (Q<sup>2</sup> = 0.87, Q<sup>2</sup> = 0.98, and Q<sup>2</sup> = 0.68, respectively). Fecal amounts of acetate, propionate, and butyrate were higher in HT versus NT patients (<i>p</i> = 0.027; <i>p</i> = 0.015 and <i>p</i> = 0.015, respectively), as well as in non-dippers versus dippers (<i>p</i> = 0.027, <i>p</i> = 0.038, and <i>p</i> = 0.036, respectively) in the entire cohort. SCFA levels were significantly different in patients changing of dipping status over the 5-year follow-up. In conclusion, stool metabolome changes upon global and circadian BP profiles in both genders.https://www.mdpi.com/2218-1989/11/5/282arterial hypertensiondipping statusgut microbiotashort chain fatty acidsacetatebutyrate |
| spellingShingle | Justine Huart Arianna Cirillo Bernard Taminiau Julie Descy Annie Saint-Remy Georges Daube Jean-Marie Krzesinski Pierrette Melin Pascal de Tullio François Jouret Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study Metabolites arterial hypertension dipping status gut microbiota short chain fatty acids acetate butyrate |
| title | Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study |
| title_full | Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study |
| title_fullStr | Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study |
| title_full_unstemmed | Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study |
| title_short | Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study |
| title_sort | human stool metabolome differs upon 24 h blood pressure levels and blood pressure dipping status a prospective longitudinal study |
| topic | arterial hypertension dipping status gut microbiota short chain fatty acids acetate butyrate |
| url | https://www.mdpi.com/2218-1989/11/5/282 |
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