Combined Photosensitization and Vaccination Enable CD8 T-Cell Immunity and Tumor Suppression Independent of CD4 T-Cell Help

Combined Photosensitization and Vaccination Enable CD8 T-Cell Immunity and Tumor Suppression Independent of CD4 T-Cell Help

Cytotoxic T lymphocytes (CTLs) are key players in fighting cancer, and their induction is a major focus in the design of therapeutic vaccines. Yet, therapeutic vaccine efficacy is limited, in part due to the suboptimal vaccine processing by antigen-presenting cells (APCs). Such processing typically...

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Bibliographic Details
Main Authors: Eleni Maria Varypataki, Fabio Hasler, Ying Waeckerle-Men, Sarah Vogel-Kindgen, Anders Høgset, Thomas M. Kündig, Bruno Gander, Cornelia Halin, Pål Johansen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
vaccine
photochemical internalization
cancer immunotherapy
melanoma
cytotoxic T cells
T-helper cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01548/full

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