Racial differences in the associations between adiposity, placental growth hormone and inflammatory cytokines in pregnant women
BackgroundThe prevalence of obesity among women of child-bearing age has contributed to an increased risk of pregnancy complications with a disproportional impact on women of lower socioeconomic status and among certain racial groups. In particular, socio-demographic and historical factors have resu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1100724/full |
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| author | Camille Y. Williams Camille Y. Williams Amanda Wylie Amanda Wylie Verina Ghobrial Christopher L. Coe Sarah J. Short Sarah J. Short |
| author_facet | Camille Y. Williams Camille Y. Williams Amanda Wylie Amanda Wylie Verina Ghobrial Christopher L. Coe Sarah J. Short Sarah J. Short |
| author_sort | Camille Y. Williams |
| collection | DOAJ |
| description | BackgroundThe prevalence of obesity among women of child-bearing age has contributed to an increased risk of pregnancy complications with a disproportional impact on women of lower socioeconomic status and among certain racial groups. In particular, socio-demographic and historical factors have resulted in higher rates of premature births and small-for-gestational age infants among Black women, which may be associated with placental function during pregnancy. The current study investigated the influence of maternal pre-pregnancy adiposity and race on the associations between inflammatory proteins, placental growth hormone (PGH), and infant birthweight. This information was collected for a subsample of 109 participants (Black, n = 39 vs. White, n = 70) from the Brain and Early Experiences (BEE) study.MethodsSerum samples were acquired late in the second trimester to assess PGH levels, C-reactive protein (CRP), interleukin 6 (IL-6), interleukin 8 (IL-8), and interleukin-1 receptor antagonist (IL-1Ra). Participant questionnaire responses provided information on pre-pregnancy BMI, health, race, educational attainment, and infant birthweight. Bivariate correlations and multiple linear regression models were utilized to evaluate associations by race between preconception adiposity, inflammatory markers and PGH.ResultsAfter controlling for covariates including maternal age and education, gestational age, and fetal sex, regression models indicated that pre-pregnancy BMI was negatively associated with PGH (β=-0.42, p<0.05) and IL-8 was positively associated with PGH (β=0.35, p<0.05) among the Black mothers only; neither were significantly associated with PGH in the White mothers. When extending models to birth outcomes, BMI was positively associated with birthweight corrected for gestational age (BWz) (β=0.24, p<0.05) and educational attainment was negatively associated with BWz (β=0.28, p<0.05) for infants of White women. In contrast, neither variable was predictive of BWz for infants of Black mothers.ConclusionFuture work is needed to investigate racial differences in the association between adiposity and placental functioning, which are likely to contribute to differential effects on pregnancy outcomes and fetal growth. |
| first_indexed | 2024-04-09T23:22:12Z |
| format | Article |
| id | doaj.art-c00d1816f0b542049996932e39213789 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T23:22:12Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-c00d1816f0b542049996932e392137892023-03-21T15:54:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11007241100724Racial differences in the associations between adiposity, placental growth hormone and inflammatory cytokines in pregnant womenCamille Y. Williams0Camille Y. Williams1Amanda Wylie2Amanda Wylie3Verina Ghobrial4Christopher L. Coe5Sarah J. Short6Sarah J. Short7Department of Counseling Psychology, University of Wisconsin–Madison, Madison, WI, United StatesCenter for Healthy Minds, University of Wisconsin–Madison, Madison, WI, United StatesFrank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDepartment of Educational Psychology, University of Wisconsin–Madison, Madison, WI, United StatesHarlow Center for Biological Psychology, University of Wisconsin–Madison, Madison, WI, United StatesCenter for Healthy Minds, University of Wisconsin–Madison, Madison, WI, United StatesDepartment of Educational Psychology, University of Wisconsin–Madison, Madison, WI, United StatesBackgroundThe prevalence of obesity among women of child-bearing age has contributed to an increased risk of pregnancy complications with a disproportional impact on women of lower socioeconomic status and among certain racial groups. In particular, socio-demographic and historical factors have resulted in higher rates of premature births and small-for-gestational age infants among Black women, which may be associated with placental function during pregnancy. The current study investigated the influence of maternal pre-pregnancy adiposity and race on the associations between inflammatory proteins, placental growth hormone (PGH), and infant birthweight. This information was collected for a subsample of 109 participants (Black, n = 39 vs. White, n = 70) from the Brain and Early Experiences (BEE) study.MethodsSerum samples were acquired late in the second trimester to assess PGH levels, C-reactive protein (CRP), interleukin 6 (IL-6), interleukin 8 (IL-8), and interleukin-1 receptor antagonist (IL-1Ra). Participant questionnaire responses provided information on pre-pregnancy BMI, health, race, educational attainment, and infant birthweight. Bivariate correlations and multiple linear regression models were utilized to evaluate associations by race between preconception adiposity, inflammatory markers and PGH.ResultsAfter controlling for covariates including maternal age and education, gestational age, and fetal sex, regression models indicated that pre-pregnancy BMI was negatively associated with PGH (β=-0.42, p<0.05) and IL-8 was positively associated with PGH (β=0.35, p<0.05) among the Black mothers only; neither were significantly associated with PGH in the White mothers. When extending models to birth outcomes, BMI was positively associated with birthweight corrected for gestational age (BWz) (β=0.24, p<0.05) and educational attainment was negatively associated with BWz (β=0.28, p<0.05) for infants of White women. In contrast, neither variable was predictive of BWz for infants of Black mothers.ConclusionFuture work is needed to investigate racial differences in the association between adiposity and placental functioning, which are likely to contribute to differential effects on pregnancy outcomes and fetal growth.https://www.frontiersin.org/articles/10.3389/fendo.2023.1100724/fullplacental growth hormoneobesityinflammationpregnancyBlack or African Americanbirthweight |
| spellingShingle | Camille Y. Williams Camille Y. Williams Amanda Wylie Amanda Wylie Verina Ghobrial Christopher L. Coe Sarah J. Short Sarah J. Short Racial differences in the associations between adiposity, placental growth hormone and inflammatory cytokines in pregnant women Frontiers in Endocrinology placental growth hormone obesity inflammation pregnancy Black or African American birthweight |
| title | Racial differences in the associations between adiposity, placental growth hormone and inflammatory cytokines in pregnant women |
| title_full | Racial differences in the associations between adiposity, placental growth hormone and inflammatory cytokines in pregnant women |
| title_fullStr | Racial differences in the associations between adiposity, placental growth hormone and inflammatory cytokines in pregnant women |
| title_full_unstemmed | Racial differences in the associations between adiposity, placental growth hormone and inflammatory cytokines in pregnant women |
| title_short | Racial differences in the associations between adiposity, placental growth hormone and inflammatory cytokines in pregnant women |
| title_sort | racial differences in the associations between adiposity placental growth hormone and inflammatory cytokines in pregnant women |
| topic | placental growth hormone obesity inflammation pregnancy Black or African American birthweight |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1100724/full |
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