Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells
Pancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreati...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | FEBS Open Bio |
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| Online Access: | https://doi.org/10.1016/j.fob.2014.12.001 |
| _version_ | 1811206050095824896 |
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| author | Tadaho Nakamura Takeo Yoshikawa Fumito Naganuma Attayeb Mohsen Tomomitsu Iida Yamato Miura Akira Sugawara Kazuhiko Yanai |
| author_facet | Tadaho Nakamura Takeo Yoshikawa Fumito Naganuma Attayeb Mohsen Tomomitsu Iida Yamato Miura Akira Sugawara Kazuhiko Yanai |
| author_sort | Tadaho Nakamura |
| collection | DOAJ |
| description | Pancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreatic α‐cells and αTC1.6 cells, a mouse pancreatic α‐cell line. H3R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca2+ concentration. We also found that immepip, a selective H3R agonist, decreased serum glucagon concentration in rats. These results suggest that H3R modulates glucagon secretion from pancreatic α‐cells. |
| first_indexed | 2024-04-12T03:41:21Z |
| format | Article |
| id | doaj.art-c00d4d6626c04ff4a7d6ba18b6ee136e |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-04-12T03:41:21Z |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-c00d4d6626c04ff4a7d6ba18b6ee136e2022-12-22T03:49:16ZengWileyFEBS Open Bio2211-54632015-01-0151364110.1016/j.fob.2014.12.001Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cellsTadaho Nakamura0Takeo Yoshikawa1Fumito Naganuma2Attayeb Mohsen3Tomomitsu Iida4Yamato Miura5Akira Sugawara6Kazuhiko Yanai7Department of Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartment of Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartment of Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartment of Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartment of Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartment of Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartment of Molecular Endocrinology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartment of Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanPancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreatic α‐cells and αTC1.6 cells, a mouse pancreatic α‐cell line. H3R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca2+ concentration. We also found that immepip, a selective H3R agonist, decreased serum glucagon concentration in rats. These results suggest that H3R modulates glucagon secretion from pancreatic α‐cells.https://doi.org/10.1016/j.fob.2014.12.001Histamine H3 receptorGlucagon secretionPancreatic α-cellsαTC1.6 cells |
| spellingShingle | Tadaho Nakamura Takeo Yoshikawa Fumito Naganuma Attayeb Mohsen Tomomitsu Iida Yamato Miura Akira Sugawara Kazuhiko Yanai Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells FEBS Open Bio Histamine H3 receptor Glucagon secretion Pancreatic α-cells αTC1.6 cells |
| title | Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells |
| title_full | Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells |
| title_fullStr | Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells |
| title_full_unstemmed | Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells |
| title_short | Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells |
| title_sort | role of histamine h3 receptor in glucagon secreting αtc1 6 cells |
| topic | Histamine H3 receptor Glucagon secretion Pancreatic α-cells αTC1.6 cells |
| url | https://doi.org/10.1016/j.fob.2014.12.001 |
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