A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function

A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function

Abstract Background Tumors can employ different mechanisms to evade immune surveillance and function. Overexpression of co-inhibitory ligands that bind to checkpoint molecules on the surface of T-cells can greatly impair the function of latter. TIGIT (T cell immunoreceptor with Ig and ITIM domains)...

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Bibliographic Details
Main Authors: Shiran Hoogi, Vasyl Eisenberg, Shimrit Mayer, Astar Shamul, Tilda Barliya, Cyrille J. Cohen
Format: Article
Language:English
Published: BMJ Publishing Group 2019-09-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
TIGIT
T-cell engineering
Tumor immunotherapy
Costimulation
Chimeric receptors
Online Access:http://link.springer.com/article/10.1186/s40425-019-0721-y

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